Academic Journal
View in EDS

Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample

Bibliographic Details
Title: Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample
Authors: Pavel Cuevas Diaz, Humberto Nicolini, German Alberto Nolasco-Rosales, Isela Juarez Rojop, Carlos Alfonso Tovilla-Zarate, Ester Rodriguez Sanchez, Alma Delia Genis-Mendoza
Source: Biomedicines, Vol 11, Iss 3, p 730 (2023)
Publisher Information: MDPI AG, 2023.
Publication Year: 2023
Collection: LCC:Biology (General)
Subject Terms: telomere length, telomere shortening, diabetes, Mexicans, Biology (General), QH301-705.5
More Details: This study aimed to explore the role of telomere length in three different diabetes types: latent autoimmune diabetes of adulthood (LADA), latent autoimmune diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 patients were included, 72 (62.61%) had LADA, 30 (26.09%) had T2DM, and 13 (11.30%) had LADY. Telomere length was measured using real-time Polymerase Chain Reaction. For statistical analysis, we used the ANOVA test, X2 test, and the Mann–Whitney U test. Patients with T2DM had higher BMI compared to LADA and LADY groups, with a BMI average of 31.32 kg/m2 (p = 0.0235). While the LADA group had more patients with comorbidities, there was not a statistically significant difference (p = 0.3164, p = 0.3315, p = 0.3742 for each of the previously mentioned conditions). There was a difference between those patients with T2DM who took metformin plus any other oral antidiabetic agent and those who took metformin plus insulin, the ones who had longer telomeres. LADA patients had shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, T2DM may have longer telomeres thanks to the protective effects of both metformin and insulin, despite the higher BMI in this group.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2227-9059
Relation: https://www.mdpi.com/2227-9059/11/3/730; https://doaj.org/toc/2227-9059
DOI: 10.3390/biomedicines11030730
Access URL: https://doaj.org/article/f29c538b056e4ef081aab6e2ce49a076
Accession Number: edsdoj.f29c538b056e4ef081aab6e2ce49a076
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=22279059&ISBN=&volume=11&issue=3&date=20230201&spage=730&pages=730-730&title=Biomedicines&atitle=Telomere%20Shortening%20in%20Three%20Diabetes%20Mellitus%20Types%20in%20a%20Mexican%20Sample&aulast=Pavel%20Cuevas%20Diaz&id=DOI:10.3390/biomedicines11030730
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/f29c538b056e4ef081aab6e2ce49a076
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.f29c538b056e4ef081aab6e2ce49a076
RelevancyScore: 936
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 935.989685058594
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pavel+Cuevas+Diaz%22">Pavel Cuevas Diaz</searchLink><br /><searchLink fieldCode="AR" term="%22Humberto+Nicolini%22">Humberto Nicolini</searchLink><br /><searchLink fieldCode="AR" term="%22German+Alberto+Nolasco-Rosales%22">German Alberto Nolasco-Rosales</searchLink><br /><searchLink fieldCode="AR" term="%22Isela+Juarez+Rojop%22">Isela Juarez Rojop</searchLink><br /><searchLink fieldCode="AR" term="%22Carlos+Alfonso+Tovilla-Zarate%22">Carlos Alfonso Tovilla-Zarate</searchLink><br /><searchLink fieldCode="AR" term="%22Ester+Rodriguez+Sanchez%22">Ester Rodriguez Sanchez</searchLink><br /><searchLink fieldCode="AR" term="%22Alma+Delia+Genis-Mendoza%22">Alma Delia Genis-Mendoza</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Biomedicines, Vol 11, Iss 3, p 730 (2023)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: MDPI AG, 2023.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Biology (General)
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22telomere+length%22">telomere length</searchLink><br /><searchLink fieldCode="DE" term="%22telomere+shortening%22">telomere shortening</searchLink><br /><searchLink fieldCode="DE" term="%22diabetes%22">diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Mexicans%22">Mexicans</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: This study aimed to explore the role of telomere length in three different diabetes types: latent autoimmune diabetes of adulthood (LADA), latent autoimmune diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 patients were included, 72 (62.61%) had LADA, 30 (26.09%) had T2DM, and 13 (11.30%) had LADY. Telomere length was measured using real-time Polymerase Chain Reaction. For statistical analysis, we used the ANOVA test, X2 test, and the Mann–Whitney U test. Patients with T2DM had higher BMI compared to LADA and LADY groups, with a BMI average of 31.32 kg/m2 (p = 0.0235). While the LADA group had more patients with comorbidities, there was not a statistically significant difference (p = 0.3164, p = 0.3315, p = 0.3742 for each of the previously mentioned conditions). There was a difference between those patients with T2DM who took metformin plus any other oral antidiabetic agent and those who took metformin plus insulin, the ones who had longer telomeres. LADA patients had shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, T2DM may have longer telomeres thanks to the protective effects of both metformin and insulin, despite the higher BMI in this group.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2227-9059
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://www.mdpi.com/2227-9059/11/3/730; https://doaj.org/toc/2227-9059
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3390/biomedicines11030730
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/f29c538b056e4ef081aab6e2ce49a076" linkWindow="_blank">https://doaj.org/article/f29c538b056e4ef081aab6e2ce49a076</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.f29c538b056e4ef081aab6e2ce49a076
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.f29c538b056e4ef081aab6e2ce49a076
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/biomedicines11030730
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: 730
    Subjects:
      – SubjectFull: telomere length
        Type: general
      – SubjectFull: telomere shortening
        Type: general
      – SubjectFull: diabetes
        Type: general
      – SubjectFull: Mexicans
        Type: general
      – SubjectFull: Biology (General)
        Type: general
      – SubjectFull: QH301-705.5
        Type: general
    Titles:
      – TitleFull: Telomere Shortening in Three Diabetes Mellitus Types in a Mexican Sample
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pavel Cuevas Diaz
      – PersonEntity:
          Name:
            NameFull: Humberto Nicolini
      – PersonEntity:
          Name:
            NameFull: German Alberto Nolasco-Rosales
      – PersonEntity:
          Name:
            NameFull: Isela Juarez Rojop
      – PersonEntity:
          Name:
            NameFull: Carlos Alfonso Tovilla-Zarate
      – PersonEntity:
          Name:
            NameFull: Ester Rodriguez Sanchez
      – PersonEntity:
          Name:
            NameFull: Alma Delia Genis-Mendoza
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 22279059
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Biomedicines
              Type: main
ResultId 1