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A microarray analysis of full depth knee cartilage of ovariectomized rats

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Title: A microarray analysis of full depth knee cartilage of ovariectomized rats
Authors: Letzkus Martin, Steadtler Frank, Azria Moïse, Segovia-Silvestre Toni, Nielsen Rasmus H, Bay-Jensen Anne C, Hartmann Nicole, Brachat Arndt H, Karsdal Morten A
Source: BMC Research Notes, Vol 4, Iss 1, p 63 (2011)
Publisher Information: BMC, 2011.
Publication Year: 2011
Collection: LCC:Medicine
LCC:Biology (General)
LCC:Science (General)
Subject Terms: Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
More Details: Abstract Background This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. Findings We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. Conclusion We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1756-0500
Relation: http://www.biomedcentral.com/1756-0500/4/63; https://doaj.org/toc/1756-0500
DOI: 10.1186/1756-0500-4-63
Access URL: https://doaj.org/article/f0fe6b903e954b8ea6727d70ca0f59de
Accession Number: edsdoj.f0fe6b903e954b8ea6727d70ca0f59de
Database: Directory of Open Access Journals
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  Data: Abstract Background This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. Findings We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. Conclusion We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover.
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