Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe
| Title: | Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
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| Authors: | Fábia Regina dos Santos, Diana Matos Euzébio, Genilde Gomes de Oliveira, Mayra Souza Chagas, Alex Ricardo Ferreira, Lídia Almeida Mendonça, Dalmo Correia, Angela Maria da Silva |
| Source: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 3, Pp 310-317 |
| Publisher Information: | Sociedade Brasileira de Medicina Tropical (SBMT). |
| Collection: | LCC:Arctic medicine. Tropical medicine |
| Subject Terms: | Chagas disease, Epidemiology, Neonatal screening, Trypanosoma cruzi, Arctic medicine. Tropical medicine, RC955-962 |
| More Details: | Abstract INTRODUCTION: Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, being one of the leading causes of morbidity and mortality in the Americas with an estimated six to seven million infected people worldwide. In Brazil, the improvement in vector control and blood donor screening has evidenced the important epidemiological role of congenital transmission of Chagas disease. METHODS: A serological survey for Chagas disease was performed in 3,952 newborns in the southern region of Sergipe using paper filter disks of dried blood samples. The newborns were screened using the Sergipe State Neonatal Screening Program between July 2015 and July 2016, and 3,749 and 750 blood samples were obtained for the IgG enzyme-linked immunosorbent assay and indirect immunofluorescence assay, respectively. In addition, mothers of the children who presented initial reagent serology were examined. RESULTS: Among 3,749 blood samples, samples of two children were positive for the enzyme-linked immunosorbent assay; however, their confirmation test results were negative, suggesting passive transfer of the mother’s antibody. One puerpera was identified with Chagas disease, with a prevalence of 0.02%. CONCLUSIONS: Congenital Chagas disease was not observed in newborns in the Southern region of Sergipe. However, Chagas disease was observed in women of reproductive age. Therefore, effective measurements for monitoring and systematic evaluation should be conducted. The Neonatal Screening Program proved to be an effective public health strategy for the prevention and control of Chagas disease. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1678-9849 0037-8682 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300310&lng=en&tlng=en; https://doaj.org/toc/1678-9849 |
| DOI: | 10.1590/0037-8682-0024-2018 |
| Access URL: | https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab |
| Accession Number: | edsdoj.b9579cdba6e94dff8499959aa41e10ab |
| Database: | Directory of Open Access Journals |
| ISSN: | 16789849 00378682 |
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| DOI: | 10.1590/0037-8682-0024-2018 |
| Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
| Language: | English |