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Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants

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Title: Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants
Authors: Chen Chen, Yapeng Lin, Feifeng Liu, Xiaoying Chen, Laurent Billot, Qiang Li, Yiija Guo, Hueiming Liu, Lei Si, Menglu Ouyang, Chunfang Zhang, Hisatomi Arima, Philip M. Bath, Gary A. Ford, Thompson Robinson, Else Charlotte Sandset, Jeffrey L. Saver, Nikola Sprigg, H. Bart van der Worp, Gang Liu, Lili Song, Jie Yang, Gang Li, Craig S. Anderson, for the INTERACT4 Investigators
Source: Trials, Vol 24, Iss 1, Pp 1-9 (2023)
Publisher Information: BMC, 2023.
Publication Year: 2023
Collection: LCC:Medicine (General)
Subject Terms: Medicine (General), R5-920
More Details: Abstract Background and aims Uncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered blood pressure Reduction in hyper-Acute stroke Trial (INTERACT4) aims to determine efficacy and safety of hyperacute intensive BP lowering in patients with suspected acute stroke. Given concerns over the safety of this treatment in the pre-hospital setting, particularly in relation to patients with intracerebral hemorrhage, we provide an update on progress of the study and profile of participants to date. Methods INTERACT4 is an ongoing multicentre, ambulance-delivered, randomized, open-label, blinded endpoint trial of pre-hospital BP lowering in patients with suspected acute stroke and elevated BP in China. Patients are randomized via a mobile phone digital system to intensive (target systolic BP [SBP]
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1745-6215
Relation: https://doaj.org/toc/1745-6215
DOI: 10.1186/s13063-023-07861-5
Access URL: https://doaj.org/article/db70d4115dfe401397d3fbea50c3640b
Accession Number: edsdoj.b70d4115dfe401397d3fbea50c3640b
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  Data: Abstract Background and aims Uncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered blood pressure Reduction in hyper-Acute stroke Trial (INTERACT4) aims to determine efficacy and safety of hyperacute intensive BP lowering in patients with suspected acute stroke. Given concerns over the safety of this treatment in the pre-hospital setting, particularly in relation to patients with intracerebral hemorrhage, we provide an update on progress of the study and profile of participants to date. Methods INTERACT4 is an ongoing multicentre, ambulance-delivered, randomized, open-label, blinded endpoint trial of pre-hospital BP lowering in patients with suspected acute stroke and elevated BP in China. Patients are randomized via a mobile phone digital system to intensive (target systolic BP [SBP]
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