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Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming

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Title: Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming
Authors: Yuling Peng, Jieying Zhu, Qi Zhang, Ran Zhang, Zhenhua Wang, Zesen Ye, Ning Ma, Dajiang Qin, Duanqing Pei, Dongwei Li
Source: Cell Regeneration, Vol 13, Iss 1, Pp 1-15 (2024)
Publisher Information: SpringerOpen, 2024.
Publication Year: 2024
Collection: LCC:Medicine (General)
LCC:Biology (General)
Subject Terms: Endogenous retroviruses, ERVH48-1, Human embryonic stem cells, Induced pluripotent stem cells, Urine cell integration-free reprogramming system, Medicine (General), R5-920, Biology (General), QH301-705.5
More Details: Abstract Endogenous retroviruses (ERVs), once thought to be mere remnants of ancient viral integrations in the mammalian genome, are now recognized for their critical roles in various physiological processes, including embryonic development, innate immunity, and tumorigenesis. Their impact on host organisms is significant driver of evolutionary changes, offering insight into evolutionary mechanisms. In our study, we explored the functionality of ERVs by examining single-cell transcriptomic profiles from human embryonic stem cells and urine cells. This led to the discovery of a unique ERVH48-1 expression pattern between these cell types. Additionally, somatic cell reprogramming efficacy was enhanced when ERVH48-1 was overexpressed in a urine cell-reprogramming system. Induced pluripotent stem cells (iPSCs) generated with ERVH48-1 overexpression recapitulated the traits of those produced by traditional reprogramming approaches, and the resulting iPSCs demonstrated the capability to differentiate into all three germ layers in vitro. Our research elucidated the role of ERVs in somatic cell reprogramming.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-9769
Relation: https://doaj.org/toc/2045-9769
DOI: 10.1186/s13619-024-00200-2
Access URL: https://doaj.org/article/b45804db34c44fc8b80e56612c58a898
Accession Number: edsdoj.b45804db34c44fc8b80e56612c58a898
Database: Directory of Open Access Journals
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  Data: Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming
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  Data: <searchLink fieldCode="AR" term="%22Yuling+Peng%22">Yuling Peng</searchLink><br /><searchLink fieldCode="AR" term="%22Jieying+Zhu%22">Jieying Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Qi+Zhang%22">Qi Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Ran+Zhang%22">Ran Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhenhua+Wang%22">Zhenhua Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Zesen+Ye%22">Zesen Ye</searchLink><br /><searchLink fieldCode="AR" term="%22Ning+Ma%22">Ning Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Dajiang+Qin%22">Dajiang Qin</searchLink><br /><searchLink fieldCode="AR" term="%22Duanqing+Pei%22">Duanqing Pei</searchLink><br /><searchLink fieldCode="AR" term="%22Dongwei+Li%22">Dongwei Li</searchLink>
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  Data: Cell Regeneration, Vol 13, Iss 1, Pp 1-15 (2024)
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  Data: <searchLink fieldCode="DE" term="%22Endogenous+retroviruses%22">Endogenous retroviruses</searchLink><br /><searchLink fieldCode="DE" term="%22ERVH48-1%22">ERVH48-1</searchLink><br /><searchLink fieldCode="DE" term="%22Human+embryonic+stem+cells%22">Human embryonic stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Induced+pluripotent+stem+cells%22">Induced pluripotent stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Urine+cell+integration-free+reprogramming+system%22">Urine cell integration-free reprogramming system</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine+%28General%29%22">Medicine (General)</searchLink><br /><searchLink fieldCode="DE" term="%22R5-920%22">R5-920</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
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  Data: Abstract Endogenous retroviruses (ERVs), once thought to be mere remnants of ancient viral integrations in the mammalian genome, are now recognized for their critical roles in various physiological processes, including embryonic development, innate immunity, and tumorigenesis. Their impact on host organisms is significant driver of evolutionary changes, offering insight into evolutionary mechanisms. In our study, we explored the functionality of ERVs by examining single-cell transcriptomic profiles from human embryonic stem cells and urine cells. This led to the discovery of a unique ERVH48-1 expression pattern between these cell types. Additionally, somatic cell reprogramming efficacy was enhanced when ERVH48-1 was overexpressed in a urine cell-reprogramming system. Induced pluripotent stem cells (iPSCs) generated with ERVH48-1 overexpression recapitulated the traits of those produced by traditional reprogramming approaches, and the resulting iPSCs demonstrated the capability to differentiate into all three germ layers in vitro. Our research elucidated the role of ERVs in somatic cell reprogramming.
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  Data: 2045-9769
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      – Text: English
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      – SubjectFull: Endogenous retroviruses
        Type: general
      – SubjectFull: ERVH48-1
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      – SubjectFull: Human embryonic stem cells
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