Academic Journal
View in EDS

Decoding phase separation of prion-like domains through data-driven scaling laws

Bibliographic Details
Title: Decoding phase separation of prion-like domains through data-driven scaling laws
Authors: M Julia Maristany, Anne Aguirre Gonzalez, Jorge R Espinosa, Jan Huertas, Rosana Collepardo-Guevara, Jerelle A Joseph
Source: eLife, Vol 13 (2025)
Publisher Information: eLife Sciences Publications Ltd, 2025.
Publication Year: 2025
Collection: LCC:Medicine
LCC:Science
LCC:Biology (General)
Subject Terms: phase separation, biomolecular condensates, scaling laws, prion-like low complexity domains, disordered proteins, critical temperature, Medicine, Science, Biology (General), QH301-705.5
More Details: Proteins containing prion-like low complexity domains (PLDs) are common drivers of the formation of biomolecular condensates and are prone to misregulation due to amino acid mutations. Here, we exploit the accuracy of our residue-resolution coarse-grained model, Mpipi, to quantify the impact of amino acid mutations on the stability of 140 PLD mutants from six proteins (hnRNPA1, TDP43, FUS, EWSR1, RBM14, and TIA1). Our simulations reveal the existence of scaling laws that quantify the range of change in the critical solution temperature of PLDs as a function of the number and type of amino acid sequence mutations. These rules are consistent with the physicochemical properties of the mutations and extend across the entire family tested, suggesting that scaling laws can be used as tools to predict changes in the stability of PLD condensates. Our work offers a quantitative lens into how the emergent behavior of PLD solutions vary in response to physicochemical changes of single PLD molecules.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2050-084X
Relation: https://elifesciences.org/articles/99068; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.99068
Access URL: https://doaj.org/article/cb144abe9d0a448293b24db7f9f284db
Accession Number: edsdoj.b144abe9d0a448293b24db7f9f284db
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doaj.org/article/cb144abe9d0a448293b24db7f9f284db
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from Directory of Open Access Journals
    MouseOverText: View record from Directory of Open Access Journals
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=2050084X&ISBN=&volume=13&issue=&date=20250201&spage=&pages=&title=eLife&atitle=Decoding%20phase%20separation%20of%20prion-like%20domains%20through%20data-driven%20scaling%20laws&aulast=M%20Julia%20Maristany&id=DOI:10.7554/eLife.99068
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.b144abe9d0a448293b24db7f9f284db
RelevancyScore: 1039
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1039.240234375
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Decoding phase separation of prion-like domains through data-driven scaling laws
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22M+Julia+Maristany%22">M Julia Maristany</searchLink><br /><searchLink fieldCode="AR" term="%22Anne+Aguirre+Gonzalez%22">Anne Aguirre Gonzalez</searchLink><br /><searchLink fieldCode="AR" term="%22Jorge+R+Espinosa%22">Jorge R Espinosa</searchLink><br /><searchLink fieldCode="AR" term="%22Jan+Huertas%22">Jan Huertas</searchLink><br /><searchLink fieldCode="AR" term="%22Rosana+Collepardo-Guevara%22">Rosana Collepardo-Guevara</searchLink><br /><searchLink fieldCode="AR" term="%22Jerelle+A+Joseph%22">Jerelle A Joseph</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: eLife, Vol 13 (2025)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: eLife Sciences Publications Ltd, 2025.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine<br />LCC:Science<br />LCC:Biology (General)
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22phase+separation%22">phase separation</searchLink><br /><searchLink fieldCode="DE" term="%22biomolecular+condensates%22">biomolecular condensates</searchLink><br /><searchLink fieldCode="DE" term="%22scaling+laws%22">scaling laws</searchLink><br /><searchLink fieldCode="DE" term="%22prion-like+low+complexity+domains%22">prion-like low complexity domains</searchLink><br /><searchLink fieldCode="DE" term="%22disordered+proteins%22">disordered proteins</searchLink><br /><searchLink fieldCode="DE" term="%22critical+temperature%22">critical temperature</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Proteins containing prion-like low complexity domains (PLDs) are common drivers of the formation of biomolecular condensates and are prone to misregulation due to amino acid mutations. Here, we exploit the accuracy of our residue-resolution coarse-grained model, Mpipi, to quantify the impact of amino acid mutations on the stability of 140 PLD mutants from six proteins (hnRNPA1, TDP43, FUS, EWSR1, RBM14, and TIA1). Our simulations reveal the existence of scaling laws that quantify the range of change in the critical solution temperature of PLDs as a function of the number and type of amino acid sequence mutations. These rules are consistent with the physicochemical properties of the mutations and extend across the entire family tested, suggesting that scaling laws can be used as tools to predict changes in the stability of PLD condensates. Our work offers a quantitative lens into how the emergent behavior of PLD solutions vary in response to physicochemical changes of single PLD molecules.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2050-084X
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://elifesciences.org/articles/99068; https://doaj.org/toc/2050-084X
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.7554/eLife.99068
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/cb144abe9d0a448293b24db7f9f284db" linkWindow="_blank">https://doaj.org/article/cb144abe9d0a448293b24db7f9f284db</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.b144abe9d0a448293b24db7f9f284db
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.b144abe9d0a448293b24db7f9f284db
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.7554/eLife.99068
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: phase separation
        Type: general
      – SubjectFull: biomolecular condensates
        Type: general
      – SubjectFull: scaling laws
        Type: general
      – SubjectFull: prion-like low complexity domains
        Type: general
      – SubjectFull: disordered proteins
        Type: general
      – SubjectFull: critical temperature
        Type: general
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
      – SubjectFull: Biology (General)
        Type: general
      – SubjectFull: QH301-705.5
        Type: general
    Titles:
      – TitleFull: Decoding phase separation of prion-like domains through data-driven scaling laws
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: M Julia Maristany
      – PersonEntity:
          Name:
            NameFull: Anne Aguirre Gonzalez
      – PersonEntity:
          Name:
            NameFull: Jorge R Espinosa
      – PersonEntity:
          Name:
            NameFull: Jan Huertas
      – PersonEntity:
          Name:
            NameFull: Rosana Collepardo-Guevara
      – PersonEntity:
          Name:
            NameFull: Jerelle A Joseph
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 2050084X
          Numbering:
            – Type: volume
              Value: 13
          Titles:
            – TitleFull: eLife
              Type: main
ResultId 1