Academic Journal
View in EDS

Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score

Bibliographic Details
Title: Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score
Authors: Noor K. Abassi, Nina Nouhravesh, Mariam Elmegaard, Marte Austreim, Deewa Zahir, Caroline Hartwell Garred, Jawad H. Butt, Camilla Fuchs Andersen, Jarl E. Strange, Caroline Sindet‐Pedersen, Daniel M. Christensen, Emil Fosbøl, Charlotte Andersson, Lars Køber, Morten Schou
Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 3 (2025)
Publisher Information: Wiley, 2025.
Publication Year: 2025
Collection: LCC:Diseases of the circulatory (Cardiovascular) system
Subject Terms: all‐cause death, frailty, heart failure, hospitalization risk, time trend, Diseases of the circulatory (Cardiovascular) system, RC666-701
More Details: Background Heart failure (HF) and frailty often coexist. However, it is unknown how the interplay between HF and frailty at HF onset impacts prognosis of frail patients with HF and how this has evolved over time. Methods and Results We identified 131 235 patients with new‐onset HF (median age 74 years, 39.7% women) from Danish nationwide registers in 1999 to 2017. Stratification according to the Hospital Frailty Risk Score resulted in (1) 102 635 (78%) nonfrail, (2) 26 054 (20%) moderately frail, and (3) 2609 (2%) severely frail patients. The proportion of moderately frail patients increased from 13.2% to 24.9%. Five‐year absolute risks of all‐cause mortality, HF hospitalization, and non‐HF hospitalization were calculated using the Kaplan‐Meier and Aalen‐Johansen estimators. From 1999 to 2002 to 2003 to 2017, all‐cause mortality risk (95% CI) declined from 56.4% (55.8%–57.0%) to 33.3% (32.6%–34.1%), 79.8% (78.5%–81.0%) to 58.6% (57.2%–60.1%), and 90.8% (85.6%–96.0%) to 79.8% (76.4%–83.2%) in nonfrail, moderately frail, and severely frail patients, respectively. HF hospitalization risk remained almost constant over the study period. Non‐HF hospitalization risk declined from 74.0% (73.5%–74.5%) to 65.8% (65.0%–66.5%) in nonfrail patients and remained stable overall in moderately frail and severely frail patients over the study period. Conclusions We observed an increase in frail patients. Mortality decreased for all frailty groups but remained high for severely frail patients. These findings indicate the need for further evidence on the optimization of care for frail patients with HF, and future research should address the development of comprehensive management strategies, integrating frailty assessment into standard clinical care and focused care for older patients with HF.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2047-9980
Relation: https://doaj.org/toc/2047-9980
DOI: 10.1161/JAHA.124.037973
Access URL: https://doaj.org/article/9d2ed9ae6ad34efab3042ecf6e6dee30
Accession Number: edsdoj.9d2ed9ae6ad34efab3042ecf6e6dee30
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doaj.org/article/9d2ed9ae6ad34efab3042ecf6e6dee30
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from Directory of Open Access Journals
    MouseOverText: View record from Directory of Open Access Journals
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20479980&ISBN=&volume=14&issue=3&date=20250201&spage=&pages=&title=Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease&atitle=Temporal%20Trends%20in%20Mortality%20and%20Hospitalization%20Risk%20in%20Patients%20With%20Heart%20Failure%20According%20to%20the%20Hospital%20Frailty%20Risk%20Score&aulast=Noor%20K.%20Abassi&id=DOI:10.1161/JAHA.124.037973
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.9d2ed9ae6ad34efab3042ecf6e6dee30
RelevancyScore: 1039
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1039.240234375
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Noor+K%2E+Abassi%22">Noor K. Abassi</searchLink><br /><searchLink fieldCode="AR" term="%22Nina+Nouhravesh%22">Nina Nouhravesh</searchLink><br /><searchLink fieldCode="AR" term="%22Mariam+Elmegaard%22">Mariam Elmegaard</searchLink><br /><searchLink fieldCode="AR" term="%22Marte+Austreim%22">Marte Austreim</searchLink><br /><searchLink fieldCode="AR" term="%22Deewa+Zahir%22">Deewa Zahir</searchLink><br /><searchLink fieldCode="AR" term="%22Caroline+Hartwell+Garred%22">Caroline Hartwell Garred</searchLink><br /><searchLink fieldCode="AR" term="%22Jawad+H%2E+Butt%22">Jawad H. Butt</searchLink><br /><searchLink fieldCode="AR" term="%22Camilla+Fuchs+Andersen%22">Camilla Fuchs Andersen</searchLink><br /><searchLink fieldCode="AR" term="%22Jarl+E%2E+Strange%22">Jarl E. Strange</searchLink><br /><searchLink fieldCode="AR" term="%22Caroline+Sindet‐Pedersen%22">Caroline Sindet‐Pedersen</searchLink><br /><searchLink fieldCode="AR" term="%22Daniel+M%2E+Christensen%22">Daniel M. Christensen</searchLink><br /><searchLink fieldCode="AR" term="%22Emil+Fosbøl%22">Emil Fosbøl</searchLink><br /><searchLink fieldCode="AR" term="%22Charlotte+Andersson%22">Charlotte Andersson</searchLink><br /><searchLink fieldCode="AR" term="%22Lars+Køber%22">Lars Køber</searchLink><br /><searchLink fieldCode="AR" term="%22Morten+Schou%22">Morten Schou</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 3 (2025)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Wiley, 2025.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Diseases of the circulatory (Cardiovascular) system
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22all‐cause+death%22">all‐cause death</searchLink><br /><searchLink fieldCode="DE" term="%22frailty%22">frailty</searchLink><br /><searchLink fieldCode="DE" term="%22heart+failure%22">heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22hospitalization+risk%22">hospitalization risk</searchLink><br /><searchLink fieldCode="DE" term="%22time+trend%22">time trend</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+circulatory+%28Cardiovascular%29+system%22">Diseases of the circulatory (Cardiovascular) system</searchLink><br /><searchLink fieldCode="DE" term="%22RC666-701%22">RC666-701</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background Heart failure (HF) and frailty often coexist. However, it is unknown how the interplay between HF and frailty at HF onset impacts prognosis of frail patients with HF and how this has evolved over time. Methods and Results We identified 131 235 patients with new‐onset HF (median age 74 years, 39.7% women) from Danish nationwide registers in 1999 to 2017. Stratification according to the Hospital Frailty Risk Score resulted in (1) 102 635 (78%) nonfrail, (2) 26 054 (20%) moderately frail, and (3) 2609 (2%) severely frail patients. The proportion of moderately frail patients increased from 13.2% to 24.9%. Five‐year absolute risks of all‐cause mortality, HF hospitalization, and non‐HF hospitalization were calculated using the Kaplan‐Meier and Aalen‐Johansen estimators. From 1999 to 2002 to 2003 to 2017, all‐cause mortality risk (95% CI) declined from 56.4% (55.8%–57.0%) to 33.3% (32.6%–34.1%), 79.8% (78.5%–81.0%) to 58.6% (57.2%–60.1%), and 90.8% (85.6%–96.0%) to 79.8% (76.4%–83.2%) in nonfrail, moderately frail, and severely frail patients, respectively. HF hospitalization risk remained almost constant over the study period. Non‐HF hospitalization risk declined from 74.0% (73.5%–74.5%) to 65.8% (65.0%–66.5%) in nonfrail patients and remained stable overall in moderately frail and severely frail patients over the study period. Conclusions We observed an increase in frail patients. Mortality decreased for all frailty groups but remained high for severely frail patients. These findings indicate the need for further evidence on the optimization of care for frail patients with HF, and future research should address the development of comprehensive management strategies, integrating frailty assessment into standard clinical care and focused care for older patients with HF.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2047-9980
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2047-9980
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1161/JAHA.124.037973
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/9d2ed9ae6ad34efab3042ecf6e6dee30" linkWindow="_blank">https://doaj.org/article/9d2ed9ae6ad34efab3042ecf6e6dee30</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.9d2ed9ae6ad34efab3042ecf6e6dee30
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.9d2ed9ae6ad34efab3042ecf6e6dee30
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1161/JAHA.124.037973
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: all‐cause death
        Type: general
      – SubjectFull: frailty
        Type: general
      – SubjectFull: heart failure
        Type: general
      – SubjectFull: hospitalization risk
        Type: general
      – SubjectFull: time trend
        Type: general
      – SubjectFull: Diseases of the circulatory (Cardiovascular) system
        Type: general
      – SubjectFull: RC666-701
        Type: general
    Titles:
      – TitleFull: Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Noor K. Abassi
      – PersonEntity:
          Name:
            NameFull: Nina Nouhravesh
      – PersonEntity:
          Name:
            NameFull: Mariam Elmegaard
      – PersonEntity:
          Name:
            NameFull: Marte Austreim
      – PersonEntity:
          Name:
            NameFull: Deewa Zahir
      – PersonEntity:
          Name:
            NameFull: Caroline Hartwell Garred
      – PersonEntity:
          Name:
            NameFull: Jawad H. Butt
      – PersonEntity:
          Name:
            NameFull: Camilla Fuchs Andersen
      – PersonEntity:
          Name:
            NameFull: Jarl E. Strange
      – PersonEntity:
          Name:
            NameFull: Caroline Sindet‐Pedersen
      – PersonEntity:
          Name:
            NameFull: Daniel M. Christensen
      – PersonEntity:
          Name:
            NameFull: Emil Fosbøl
      – PersonEntity:
          Name:
            NameFull: Charlotte Andersson
      – PersonEntity:
          Name:
            NameFull: Lars Køber
      – PersonEntity:
          Name:
            NameFull: Morten Schou
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 20479980
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
              Type: main
ResultId 1