Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy
| Title: | Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy |
|---|---|
| Authors: | Zabrina L. Brumme, Francis Mwimanzi, Hope R. Lapointe, Peter K. Cheung, Yurou Sang, Maggie C. Duncan, Fatima Yaseen, Olga Agafitei, Siobhan Ennis, Kurtis Ng, Simran Basra, Li Yi Lim, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Landon Young, Hesham Ali, Bruce Ganase, Gisele Umviligihozo, F. Harrison Omondi, Kieran Atkinson, Hanwei Sudderuddin, Junine Toy, Paul Sereda, Laura Burns, Cecilia T. Costiniuk, Curtis Cooper, Aslam H. Anis, Victor Leung, Daniel Holmes, Mari L. DeMarco, Janet Simons, Malcolm Hedgcock, Marc G. Romney, Rolando Barrios, Silvia Guillemi, Chanson J. Brumme, Ralph Pantophlet, Julio S. G. Montaner, Masahiro Niikura, Marianne Harris, Mark Hull, Mark A. Brockman |
| Source: | npj Vaccines, Vol 7, Iss 1, Pp 1-12 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neutralization activities one month following the first and second COVID-19 vaccine doses, and again 3 months following the second dose, in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525–935) cells/mm3, though nadir CD4+ T-cell counts ranged as low as |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2059-0105 |
| Relation: | https://doaj.org/toc/2059-0105 |
| DOI: | 10.1038/s41541-022-00452-6 |
| Access URL: | https://doaj.org/article/aa9bbdca3ccd41fdb2e9b2db8e984af2 |
| Accession Number: | edsdoj.9bbdca3ccd41fdb2e9b2db8e984af2 |
| Database: | Directory of Open Access Journals |
Be the first to leave a comment!