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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

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Title: Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Authors: Nandan Haloi, Po-Chao Wen, Qunli Cheng, Meiying Yang, Gayathri Natarajan, Amadou K. S. Camara, Wai-Meng Kwok, Emad Tajkhorshid
Source: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Publisher Information: Nature Portfolio, 2021.
Publication Year: 2021
Collection: LCC:Biology (General)
Subject Terms: Biology (General), QH301-705.5
More Details: Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2399-3642
Relation: https://doaj.org/toc/2399-3642
DOI: 10.1038/s42003-021-02205-y
Access URL: https://doaj.org/article/9b0ee7be8cd74a3aaff79ae00681eddc
Accession Number: edsdoj.9b0ee7be8cd74a3aaff79ae00681eddc
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Nandan+Haloi%22">Nandan Haloi</searchLink><br /><searchLink fieldCode="AR" term="%22Po-Chao+Wen%22">Po-Chao Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Qunli+Cheng%22">Qunli Cheng</searchLink><br /><searchLink fieldCode="AR" term="%22Meiying+Yang%22">Meiying Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Gayathri+Natarajan%22">Gayathri Natarajan</searchLink><br /><searchLink fieldCode="AR" term="%22Amadou+K%2E+S%2E+Camara%22">Amadou K. S. Camara</searchLink><br /><searchLink fieldCode="AR" term="%22Wai-Meng+Kwok%22">Wai-Meng Kwok</searchLink><br /><searchLink fieldCode="AR" term="%22Emad+Tajkhorshid%22">Emad Tajkhorshid</searchLink>
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  Data: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
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  Data: Haloi et al. investigate the role of the hydrophobic N-terminus of hexokinase II (HKII) in their binding to mitochondrial VDAC1. They use a hybrid approach combining molecular and Brownian dynamics to show that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic surface of OMM to form a binary complex.
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