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Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth

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Title: Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth
Authors: Meng-Nan Yang, Rong Huang, Xin Liu, Ya-Jie Xu, Wen-Juan Wang, Hua He, Guang-Hui Zhang, Tao Zheng, Fang Fang, Jian-Gao Fan, Fei Li, Jun Zhang, Jiong Li, Fengxiu Ouyang, Zhong-Cheng Luo
Source: Frontiers in Endocrinology, Vol 12 (2022)
Publisher Information: Frontiers Media S.A., 2022.
Publication Year: 2022
Collection: LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms: fibroblast growth factor 19 (FGF19), gestational diabetes (GD), fetal growth, insulin, C-peptide, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
More Details: Fibroblast growth factor 19 (FGF19) has been implicated in glucose homeostasis. Gestational diabetes mellitus (GDM) enhances fetal insulin secretion and fetal growth. Girls weigh less and are more insulin resistant than boys at birth. We sought to assess whether FGF19 is associated with GDM and fetal growth and explore potential sex dimorphic associations. This was a nested case-control study in the Shanghai Birth Cohort, including 153 pairs of newborns of GDM versus euglycemic mothers matched by infant’s sex and gestational age at birth. Cord plasma FGF19, insulin, C-peptide, proinsulin, IGF-I and IGF-II concentrations were measured. Cord plasma FGF19 concentrations were similar in GDM versus euglycemic pregnancies (mean ± SD: 43.5 ± 28.2 versus 44.5 ± 30.2 pg/mL, P=0.38). FGF19 was not correlated with IGF-I or IGF-II. FGF19 concentrations were positively correlated with birth weight (r=0.23, P=0.01) and length (r=0.21, P=0.02) z scores, C-peptide (r=0.27, P=0.002) and proinsulin (r=0.27, P=0.002) concentrations in females. Each SD increment in cord plasma FGF19 was associated with a 0.25 (0.07-0.43) increase in birth weight z score in females. In contrast, FGF19 was not correlated with birth weight or length in males. These sex dimorphic associations remained after adjusting for maternal and neonatal characteristics. The study is the first to demonstrate that GDM does not matter for cord blood FGF19 concentrations. The female specific positive correlation between FGF19 and birth weight is suggestive of a sex-dimorphic role of FGF19 in fetal growth. The observations call for more studies to validate the novel findings and elucidate the underlying mechanisms.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-2392
Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.805722/full; https://doaj.org/toc/1664-2392
DOI: 10.3389/fendo.2021.805722
Access URL: https://doaj.org/article/926c676346d0410a861dd133af541575
Accession Number: edsdoj.926c676346d0410a861dd133af541575
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  Data: Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth
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  Data: <searchLink fieldCode="AR" term="%22Meng-Nan+Yang%22">Meng-Nan Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Rong+Huang%22">Rong Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Xin+Liu%22">Xin Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Ya-Jie+Xu%22">Ya-Jie Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Wen-Juan+Wang%22">Wen-Juan Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Hua+He%22">Hua He</searchLink><br /><searchLink fieldCode="AR" term="%22Guang-Hui+Zhang%22">Guang-Hui Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Tao+Zheng%22">Tao Zheng</searchLink><br /><searchLink fieldCode="AR" term="%22Fang+Fang%22">Fang Fang</searchLink><br /><searchLink fieldCode="AR" term="%22Jian-Gao+Fan%22">Jian-Gao Fan</searchLink><br /><searchLink fieldCode="AR" term="%22Fei+Li%22">Fei Li</searchLink><br /><searchLink fieldCode="AR" term="%22Jun+Zhang%22">Jun Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Jiong+Li%22">Jiong Li</searchLink><br /><searchLink fieldCode="AR" term="%22Fengxiu+Ouyang%22">Fengxiu Ouyang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhong-Cheng+Luo%22">Zhong-Cheng Luo</searchLink>
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  Data: Fibroblast growth factor 19 (FGF19) has been implicated in glucose homeostasis. Gestational diabetes mellitus (GDM) enhances fetal insulin secretion and fetal growth. Girls weigh less and are more insulin resistant than boys at birth. We sought to assess whether FGF19 is associated with GDM and fetal growth and explore potential sex dimorphic associations. This was a nested case-control study in the Shanghai Birth Cohort, including 153 pairs of newborns of GDM versus euglycemic mothers matched by infant’s sex and gestational age at birth. Cord plasma FGF19, insulin, C-peptide, proinsulin, IGF-I and IGF-II concentrations were measured. Cord plasma FGF19 concentrations were similar in GDM versus euglycemic pregnancies (mean ± SD: 43.5 ± 28.2 versus 44.5 ± 30.2 pg/mL, P=0.38). FGF19 was not correlated with IGF-I or IGF-II. FGF19 concentrations were positively correlated with birth weight (r=0.23, P=0.01) and length (r=0.21, P=0.02) z scores, C-peptide (r=0.27, P=0.002) and proinsulin (r=0.27, P=0.002) concentrations in females. Each SD increment in cord plasma FGF19 was associated with a 0.25 (0.07-0.43) increase in birth weight z score in females. In contrast, FGF19 was not correlated with birth weight or length in males. These sex dimorphic associations remained after adjusting for maternal and neonatal characteristics. The study is the first to demonstrate that GDM does not matter for cord blood FGF19 concentrations. The female specific positive correlation between FGF19 and birth weight is suggestive of a sex-dimorphic role of FGF19 in fetal growth. The observations call for more studies to validate the novel findings and elucidate the underlying mechanisms.
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      – SubjectFull: gestational diabetes (GD)
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