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MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma

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Title: MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma
Authors: Lei Lei, Zhiming Jiang, Gu Zhang, Qiaoyuan Cheng, Hongyang Lu
Source: World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-6 (2018)
Publisher Information: BMC, 2018.
Publication Year: 2018
Collection: LCC:Surgery
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: Pulmonary carcinoid, Large-cell neuroendocrine carcinoma, MGMT methylation, 1p/19q co-deletion, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details: Abstract Background The response to temozolomide (TMZ) treatment in small-cell lung cancer (SCLC) correlated with O(6)-methylguanine -DNA methyltransferase (MGMT) promoter methylation. 1p/19q co-deletion within oligodendroglioma is a responsive predictor for TMZ. Currently, the status of MGMT promoter methylation and 1p/19q co-deletion in pulmonary carcinoid (PC) and large-cell neuroendocrine carcinoma (LCNEC) is not reported. Methods Nine PC [two atypical carcinoids (AC), seven typical carcinoids (TC)] and six LCNEC patients were collected retrospectively. The pyrosequencing and fluorescence in situ hybridization were used to detect the MGMT promoter methylation and 1p/19q co-deletion in surgically resected specimens. Kaplan–Meier analysis was used to assess the rate of disease-free survival (DFS). Results MGMT promoter methylation was found in two (2/6, 15.3%) LCNEC patients but not in any PC patients. Three (3/6, 50%) 1p and two (2/6, 33.3%) 19q single deletions were found in LCNEC patients. One 1p single deletion was found in AC patients. One (1/7, 14.3%) 1p and two (2/7, 28.6%) 19q single deletions were found in TC patients. After a median follow-up of 38 months, three LCNEC patients developed distant metastasis and one patient died of LCNEC disease. The DFS of PC patients was much longer than LCNEC patients (χ 2 = 7.565, P = 0.006). Conclusions MGMT promoter methylation and 1p/19q co-deletion might not be the ideal biomarkers for TMZ treatment in TC/AC patients. Thus, the detection of MGMT promoter methylation and whether it can be used as a medication for TMZ in LCNEC patients necessitates investigation. Furthermore, 1p deletion could be a negative prognostic factor for LCNEC patients.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1477-7819
Relation: http://link.springer.com/article/10.1186/s12957-018-1413-7; https://doaj.org/toc/1477-7819
DOI: 10.1186/s12957-018-1413-7
Access URL: https://doaj.org/article/8e66663c3eb54a10b27bb8f3b406b3b5
Accession Number: edsdoj.8e66663c3eb54a10b27bb8f3b406b3b5
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  Data: MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma
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  Data: <searchLink fieldCode="AR" term="%22Lei+Lei%22">Lei Lei</searchLink><br /><searchLink fieldCode="AR" term="%22Zhiming+Jiang%22">Zhiming Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Gu+Zhang%22">Gu Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Qiaoyuan+Cheng%22">Qiaoyuan Cheng</searchLink><br /><searchLink fieldCode="AR" term="%22Hongyang+Lu%22">Hongyang Lu</searchLink>
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  Data: World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-6 (2018)
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  Data: BMC, 2018.
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  Data: 2018
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  Data: LCC:Surgery<br />LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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  Data: <searchLink fieldCode="DE" term="%22Pulmonary+carcinoid%22">Pulmonary carcinoid</searchLink><br /><searchLink fieldCode="DE" term="%22Large-cell+neuroendocrine+carcinoma%22">Large-cell neuroendocrine carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22MGMT+methylation%22">MGMT methylation</searchLink><br /><searchLink fieldCode="DE" term="%221p%2F19q+co-deletion%22">1p/19q co-deletion</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22RD1-811%22">RD1-811</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%2E+Tumors%2E+Oncology%2E+Including+cancer+and+carcinogens%22">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</searchLink><br /><searchLink fieldCode="DE" term="%22RC254-282%22">RC254-282</searchLink>
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  Label: Description
  Group: Ab
  Data: Abstract Background The response to temozolomide (TMZ) treatment in small-cell lung cancer (SCLC) correlated with O(6)-methylguanine -DNA methyltransferase (MGMT) promoter methylation. 1p/19q co-deletion within oligodendroglioma is a responsive predictor for TMZ. Currently, the status of MGMT promoter methylation and 1p/19q co-deletion in pulmonary carcinoid (PC) and large-cell neuroendocrine carcinoma (LCNEC) is not reported. Methods Nine PC [two atypical carcinoids (AC), seven typical carcinoids (TC)] and six LCNEC patients were collected retrospectively. The pyrosequencing and fluorescence in situ hybridization were used to detect the MGMT promoter methylation and 1p/19q co-deletion in surgically resected specimens. Kaplan–Meier analysis was used to assess the rate of disease-free survival (DFS). Results MGMT promoter methylation was found in two (2/6, 15.3%) LCNEC patients but not in any PC patients. Three (3/6, 50%) 1p and two (2/6, 33.3%) 19q single deletions were found in LCNEC patients. One 1p single deletion was found in AC patients. One (1/7, 14.3%) 1p and two (2/7, 28.6%) 19q single deletions were found in TC patients. After a median follow-up of 38 months, three LCNEC patients developed distant metastasis and one patient died of LCNEC disease. The DFS of PC patients was much longer than LCNEC patients (χ 2 = 7.565, P = 0.006). Conclusions MGMT promoter methylation and 1p/19q co-deletion might not be the ideal biomarkers for TMZ treatment in TC/AC patients. Thus, the detection of MGMT promoter methylation and whether it can be used as a medication for TMZ in LCNEC patients necessitates investigation. Furthermore, 1p deletion could be a negative prognostic factor for LCNEC patients.
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        Value: 10.1186/s12957-018-1413-7
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      – Text: English
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    Subjects:
      – SubjectFull: Pulmonary carcinoid
        Type: general
      – SubjectFull: Large-cell neuroendocrine carcinoma
        Type: general
      – SubjectFull: MGMT methylation
        Type: general
      – SubjectFull: 1p/19q co-deletion
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      – TitleFull: MGMT promoter methylation and 1p/19q co-deletion of surgically resected pulmonary carcinoid and large-cell neuroendocrine carcinoma
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