Academic Journal
View in EDS

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Bibliographic Details
Title: Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids
Authors: Tiago Costa, Artur Ribeiro, Raul Machado, Clarisse Ribeiro, Senentxu Lanceros-Mendez, Artur Cavaco-Paulo, Andreia Almeida, José das Neves, Marlene Lúcio, Teresa Viseu
Source: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Publisher Information: Frontiers Media S.A., 2019.
Publication Year: 2019
Collection: LCC:Biotechnology
Subject Terms: acyclovir, omega-3 fatty acids, electrospinning, poly (ε-caprolactone), polymeric fibrous dressings, Biotechnology, TP248.13-248.65
More Details: Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to leak from the application site, thus showing reduced ability to sustain local drug residence. This work reports on the production of poly (ε-caprolactone) (PCL) fibrous matrices with ACV and omega-3 fatty acids (ω3) for application as dressings to the topical treatment of orofacial herpes. PCL fibrous matrices with the co-incorporated bioactive compounds were obtained by electrospinning and characterized regarding their morphology, chemical, physical, and mechanical properties. The potential use of the developed polymeric fibrous matrices for topical applications was evaluated by: (i) the release kinetics of the bioactive compounds; (ii) the occlusive factor of the fibrous mat; (iii) ACV skin permeation capacity; and (iv) the cytotoxicity in a keratinocyte cell line. PCL fibrous matrices loaded with the bioactive compounds presented a smooth morphology and a good balance between flexibility and hardness essential to be durable for handling, while having a desirable texture to be used comfortably. The fibrous mat also provided a sustained release of ACV during 96 h and improved the skin permeability of this drug (Kp = 0.00928 ± 0.000867 cm/h) presenting also high porosity (74%) and a water vapor transmission rate (WVTR) of 881 ± 91 g/m2day, essential to maintain moist and oxygen for faster healing of herpes lesions. Furthermore, cytotoxicity studies suggest that the fibrous mat are safe for topical application. Overall, the PCL based electrospun fibrous matrices with ACV and ω3 hereby described have the potential to be used as therapeutic bandage systems for the treatment of orofacial herpes.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2296-4185
Relation: https://www.frontiersin.org/article/10.3389/fbioe.2019.00390/full; https://doaj.org/toc/2296-4185
DOI: 10.3389/fbioe.2019.00390
Access URL: https://doaj.org/article/8b9f0e6974294081bc06cfc5a3570d19
Accession Number: edsdoj.8b9f0e6974294081bc06cfc5a3570d19
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=22964185&ISBN=&volume=7&issue=&date=20191201&spage=&pages=&title=Frontiers in Bioengineering and Biotechnology&atitle=Polymeric%20Electrospun%20Fibrous%20Dressings%20for%20Topical%20Co-delivery%20of%20Acyclovir%20and%20Omega-3%20Fatty%20Acids&aulast=Tiago%20Costa&id=DOI:10.3389/fbioe.2019.00390
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/8b9f0e6974294081bc06cfc5a3570d19
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.8b9f0e6974294081bc06cfc5a3570d19
RelevancyScore: 904
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 903.834228515625
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tiago+Costa%22">Tiago Costa</searchLink><br /><searchLink fieldCode="AR" term="%22Artur+Ribeiro%22">Artur Ribeiro</searchLink><br /><searchLink fieldCode="AR" term="%22Raul+Machado%22">Raul Machado</searchLink><br /><searchLink fieldCode="AR" term="%22Clarisse+Ribeiro%22">Clarisse Ribeiro</searchLink><br /><searchLink fieldCode="AR" term="%22Senentxu+Lanceros-Mendez%22">Senentxu Lanceros-Mendez</searchLink><br /><searchLink fieldCode="AR" term="%22Artur+Cavaco-Paulo%22">Artur Cavaco-Paulo</searchLink><br /><searchLink fieldCode="AR" term="%22Andreia+Almeida%22">Andreia Almeida</searchLink><br /><searchLink fieldCode="AR" term="%22José+das+Neves%22">José das Neves</searchLink><br /><searchLink fieldCode="AR" term="%22Marlene+Lúcio%22">Marlene Lúcio</searchLink><br /><searchLink fieldCode="AR" term="%22Teresa+Viseu%22">Teresa Viseu</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Frontiers Media S.A., 2019.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2019
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Biotechnology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22acyclovir%22">acyclovir</searchLink><br /><searchLink fieldCode="DE" term="%22omega-3+fatty+acids%22">omega-3 fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22electrospinning%22">electrospinning</searchLink><br /><searchLink fieldCode="DE" term="%22poly+%28ε-caprolactone%29%22">poly (ε-caprolactone)</searchLink><br /><searchLink fieldCode="DE" term="%22polymeric+fibrous+dressings%22">polymeric fibrous dressings</searchLink><br /><searchLink fieldCode="DE" term="%22Biotechnology%22">Biotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22TP248%2E13-248%2E65%22">TP248.13-248.65</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to leak from the application site, thus showing reduced ability to sustain local drug residence. This work reports on the production of poly (ε-caprolactone) (PCL) fibrous matrices with ACV and omega-3 fatty acids (ω3) for application as dressings to the topical treatment of orofacial herpes. PCL fibrous matrices with the co-incorporated bioactive compounds were obtained by electrospinning and characterized regarding their morphology, chemical, physical, and mechanical properties. The potential use of the developed polymeric fibrous matrices for topical applications was evaluated by: (i) the release kinetics of the bioactive compounds; (ii) the occlusive factor of the fibrous mat; (iii) ACV skin permeation capacity; and (iv) the cytotoxicity in a keratinocyte cell line. PCL fibrous matrices loaded with the bioactive compounds presented a smooth morphology and a good balance between flexibility and hardness essential to be durable for handling, while having a desirable texture to be used comfortably. The fibrous mat also provided a sustained release of ACV during 96 h and improved the skin permeability of this drug (Kp = 0.00928 ± 0.000867 cm/h) presenting also high porosity (74%) and a water vapor transmission rate (WVTR) of 881 ± 91 g/m2day, essential to maintain moist and oxygen for faster healing of herpes lesions. Furthermore, cytotoxicity studies suggest that the fibrous mat are safe for topical application. Overall, the PCL based electrospun fibrous matrices with ACV and ω3 hereby described have the potential to be used as therapeutic bandage systems for the treatment of orofacial herpes.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2296-4185
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://www.frontiersin.org/article/10.3389/fbioe.2019.00390/full; https://doaj.org/toc/2296-4185
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3389/fbioe.2019.00390
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/8b9f0e6974294081bc06cfc5a3570d19" linkWindow="_blank">https://doaj.org/article/8b9f0e6974294081bc06cfc5a3570d19</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.8b9f0e6974294081bc06cfc5a3570d19
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.8b9f0e6974294081bc06cfc5a3570d19
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fbioe.2019.00390
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: acyclovir
        Type: general
      – SubjectFull: omega-3 fatty acids
        Type: general
      – SubjectFull: electrospinning
        Type: general
      – SubjectFull: poly (ε-caprolactone)
        Type: general
      – SubjectFull: polymeric fibrous dressings
        Type: general
      – SubjectFull: Biotechnology
        Type: general
      – SubjectFull: TP248.13-248.65
        Type: general
    Titles:
      – TitleFull: Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tiago Costa
      – PersonEntity:
          Name:
            NameFull: Artur Ribeiro
      – PersonEntity:
          Name:
            NameFull: Raul Machado
      – PersonEntity:
          Name:
            NameFull: Clarisse Ribeiro
      – PersonEntity:
          Name:
            NameFull: Senentxu Lanceros-Mendez
      – PersonEntity:
          Name:
            NameFull: Artur Cavaco-Paulo
      – PersonEntity:
          Name:
            NameFull: Andreia Almeida
      – PersonEntity:
          Name:
            NameFull: José das Neves
      – PersonEntity:
          Name:
            NameFull: Marlene Lúcio
      – PersonEntity:
          Name:
            NameFull: Teresa Viseu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 22964185
          Numbering:
            – Type: volume
              Value: 7
          Titles:
            – TitleFull: Frontiers in Bioengineering and Biotechnology
              Type: main
ResultId 1