Biological activity of flavonoids from Sonchus brachyotus
| Title: | Biological activity of flavonoids from Sonchus brachyotus |
|---|---|
| Authors: | Jeong Min Lee, Mi-Jin Yim, Hyun-Soo Kim, Seok-Chun Ko, Ji-Yul Kim, Jung Min Shin, Dae-Sung Lee |
| Source: | Fisheries and Aquatic Sciences, Vol 24, Iss 12, Pp 428-436 (2021) |
| Publisher Information: | The Korean Society of Fisheries and Aquatic Science, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Aquaculture. Fisheries. Angling |
| Subject Terms: | anti-inflammatory, antioxidant, flavonoids, luteolin, luteolin-7-o-β-d-glucoside, Aquaculture. Fisheries. Angling, SH1-691 |
| More Details: | The aim of this study was to isolate and identify secondary metabolites from Sonchus brachyotus and evaluate their antioxidant and anti-inflammatory activities. In this study, we isolated three flavonoids from a 70% EtOH extract by Medium Pressure Liquid Chromatography (MPLC) and prep-High-Performance Liquid Chromatography (HPLC). To evaluate the biological activities (an-tioxidant and anti-inflammatory) of these flavonoids, their in vitro inhibitory activities against lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) generation, nitric oxide (NO) production, and prostaglandin E2 (PGE2) secretion were determined. We successfully identified three flavonoids, namely luteolin (1), luteolin-7-O-β-D-glucoside (2), and luteolin-7-O-β-D-glucuronide (3) by spectral analyses. Luteolin (1) at 20 μg/mL inhibited ROS generation, NO production, and PGE2 secretion by 48.6%, 61.28% and 12.10%, respectively, and luteolin-7-O-β-D-glucoside (2) inhibited NO and PGE2 generation by 67.03% and 20.82%, respectively. Luteolin (1) and luteolin-7-O-β-D-glucoside (2) showed similar anti-inflammatory activities; however, luteolin (1) was observed to be a stronger antioxidant. Besides antioxidant and anti-inflammatory activities, S. brachyotus extract containing luteolin (1) and lu-teolin-7-O-β-D-glucoside (2) is considered to possess diverse biological activities. The results indicate that S. brachyotus is an edible medicinal plant, which is believed to be significant resource of functional foods. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2234-1757 |
| Relation: | http://www.e-fas.org/archive/view_article?pid=fas-24-12-428; https://doaj.org/toc/2234-1757 |
| DOI: | 10.47853/FAS.2021.e44 |
| Access URL: | https://doaj.org/article/8abfc6f6ab844bebb4b56e6d505aa5f0 |
| Accession Number: | edsdoj.8abfc6f6ab844bebb4b56e6d505aa5f0 |
| Database: | Directory of Open Access Journals |
Be the first to leave a comment!