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The Roles of H19 in Regulating Inflammation and Aging

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Title: The Roles of H19 in Regulating Inflammation and Aging
Authors: Bin Wang, Chun Wai Suen, Haibin Ma, Yan Wang, Ling Kong, Dajiang Qin, Yuk Wai Wayne Lee, Gang Li
Source: Frontiers in Immunology, Vol 11 (2020)
Publisher Information: Frontiers Media S.A., 2020.
Publication Year: 2020
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: long non-coding RNA, H19, aging, inflammation, stress, signaling network, Immunologic diseases. Allergy, RC581-607
More Details: Accumulating evidence suggests that long non-coding RNA H19 correlates with several aging processes. However, the role of H19 in aging remains unclear. Many studies have elucidated a close connection between H19 and inflammatory genes. Chronic systemic inflammation is an established factor associated with various diseases during aging. Thus, H19 might participate in the development of age-related diseases by interplay with inflammation and therefore provide a protective function against age-related diseases. We investigated the inflammatory gene network of H19 to understand its regulatory mechanisms. H19 usually controls gene expression by acting as a microRNA sponge, or through mir-675, or by leading various protein complexes to genes at the chromosome level. The regulatory gene network has been intensively studied, whereas the biogenesis of H19 remains largely unknown. This literature review found that the epithelial-mesenchymal transition (EMT) and an imprinting gene network (IGN) might link H19 with inflammation. Evidence indicates that EMT and IGN are also tightly controlled by environmental stress. We propose that H19 is a stress-induced long non-coding RNA. Because environmental stress is a recognized age-related factor, inflammation and H19 might serve as a therapeutic axis to fight against age-related diseases.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-3224
Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.579687/full; https://doaj.org/toc/1664-3224
DOI: 10.3389/fimmu.2020.579687
Access URL: https://doaj.org/article/7ee32a489dd14b6abef348efeb304ba7
Accession Number: edsdoj.7ee32a489dd14b6abef348efeb304ba7
Database: Directory of Open Access Journals
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  Data: The Roles of H19 in Regulating Inflammation and Aging
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  Data: <searchLink fieldCode="AR" term="%22Bin+Wang%22">Bin Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Chun+Wai+Suen%22">Chun Wai Suen</searchLink><br /><searchLink fieldCode="AR" term="%22Haibin+Ma%22">Haibin Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Yan+Wang%22">Yan Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Ling+Kong%22">Ling Kong</searchLink><br /><searchLink fieldCode="AR" term="%22Dajiang+Qin%22">Dajiang Qin</searchLink><br /><searchLink fieldCode="AR" term="%22Yuk+Wai+Wayne+Lee%22">Yuk Wai Wayne Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Gang+Li%22">Gang Li</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22long+non-coding+RNA%22">long non-coding RNA</searchLink><br /><searchLink fieldCode="DE" term="%22H19%22">H19</searchLink><br /><searchLink fieldCode="DE" term="%22aging%22">aging</searchLink><br /><searchLink fieldCode="DE" term="%22inflammation%22">inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22stress%22">stress</searchLink><br /><searchLink fieldCode="DE" term="%22signaling+network%22">signaling network</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
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  Data: Accumulating evidence suggests that long non-coding RNA H19 correlates with several aging processes. However, the role of H19 in aging remains unclear. Many studies have elucidated a close connection between H19 and inflammatory genes. Chronic systemic inflammation is an established factor associated with various diseases during aging. Thus, H19 might participate in the development of age-related diseases by interplay with inflammation and therefore provide a protective function against age-related diseases. We investigated the inflammatory gene network of H19 to understand its regulatory mechanisms. H19 usually controls gene expression by acting as a microRNA sponge, or through mir-675, or by leading various protein complexes to genes at the chromosome level. The regulatory gene network has been intensively studied, whereas the biogenesis of H19 remains largely unknown. This literature review found that the epithelial-mesenchymal transition (EMT) and an imprinting gene network (IGN) might link H19 with inflammation. Evidence indicates that EMT and IGN are also tightly controlled by environmental stress. We propose that H19 is a stress-induced long non-coding RNA. Because environmental stress is a recognized age-related factor, inflammation and H19 might serve as a therapeutic axis to fight against age-related diseases.
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        Value: 10.3389/fimmu.2020.579687
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      – Text: English
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      – SubjectFull: long non-coding RNA
        Type: general
      – SubjectFull: H19
        Type: general
      – SubjectFull: aging
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      – SubjectFull: inflammation
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