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CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration

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Title: CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration
Authors: Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy
Source: Frontiers in Neurology, Vol 9 (2018)
Publisher Information: Frontiers Media S.A., 2018.
Publication Year: 2018
Collection: LCC:Neurology. Diseases of the nervous system
Subject Terms: multiple sclerois and neuroimmunology, neurofilament light chain (NFL), amyotrofic lateral sclerosis, primary progressive multiple sclerosis, cerebrospical fluid (CSF), Neurology. Diseases of the nervous system, RC346-429
More Details: Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid (CSF) are a biomarker representing axonal neurodegeneration in rapid progressive neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). It is unclear to what extent the levels of NFL increase in the CSF (CSF-NFL) in a chronic neuroinflammatory process with axonal neurodegeneration, as found in primary progressive multiple sclerosis (PPMS).Methods: We used a multicenter approach to statistically compare CSF-NFL levels between PPMS patients (n = 50), ALS patients (n = 50), and healthy controls (n = 50). Clinical findings, including disease duration, expanded disability status scale (EDSS), electrophysiological recordings such as visual evoked potentials or spinal and cerebral MRI, and previously administered treatment were selected as experimental parameters retrospectively.Results: Median [range] CSF-NFL concentrations in PPMS patients were significantly higher than in the controls [1724 (799–4275) pg/ml vs. 1202 (612–2934) pg/ml, p = 0.015], and significantly lower compared to ALS patients [1724 (799–4275) pg/ml vs. 10238 (2610–35138) pg/ml, p < 0.001]. There was no correlation between CSF-NFL and disease duration (p = 0.5), EDSS (p = 0.2) or treatment (p = 0.3).Conclusion: We conclude that CSF-NFL may mirror the proposed slow axonal degeneration in PPMS, but does not reflect the disease severity.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-2295
Relation: https://www.frontiersin.org/article/10.3389/fneur.2018.01037/full; https://doaj.org/toc/1664-2295
DOI: 10.3389/fneur.2018.01037
Access URL: https://doaj.org/article/7c15b80536a74f33aa837dc6df65adfa
Accession Number: edsdoj.7c15b80536a74f33aa837dc6df65adfa
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  Data: LCC:Neurology. Diseases of the nervous system
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22multiple+sclerois+and+neuroimmunology%22&quot;&gt;multiple sclerois and neuroimmunology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22neurofilament+light+chain+%28NFL%29%22&quot;&gt;neurofilament light chain (NFL)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22amyotrofic+lateral+sclerosis%22&quot;&gt;amyotrofic lateral sclerosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22primary+progressive+multiple+sclerosis%22&quot;&gt;primary progressive multiple sclerosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22cerebrospical+fluid+%28CSF%29%22&quot;&gt;cerebrospical fluid (CSF)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neurology%2E+Diseases+of+the+nervous+system%22&quot;&gt;Neurology. Diseases of the nervous system&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22RC346-429%22&quot;&gt;RC346-429&lt;/searchLink&gt;
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  Data: Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid (CSF) are a biomarker representing axonal neurodegeneration in rapid progressive neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). It is unclear to what extent the levels of NFL increase in the CSF (CSF-NFL) in a chronic neuroinflammatory process with axonal neurodegeneration, as found in primary progressive multiple sclerosis (PPMS).Methods: We used a multicenter approach to statistically compare CSF-NFL levels between PPMS patients (n = 50), ALS patients (n = 50), and healthy controls (n = 50). Clinical findings, including disease duration, expanded disability status scale (EDSS), electrophysiological recordings such as visual evoked potentials or spinal and cerebral MRI, and previously administered treatment were selected as experimental parameters retrospectively.Results: Median [range] CSF-NFL concentrations in PPMS patients were significantly higher than in the controls [1724 (799–4275) pg/ml vs. 1202 (612–2934) pg/ml, p = 0.015], and significantly lower compared to ALS patients [1724 (799–4275) pg/ml vs. 10238 (2610–35138) pg/ml, p &lt; 0.001]. There was no correlation between CSF-NFL and disease duration (p = 0.5), EDSS (p = 0.2) or treatment (p = 0.3).Conclusion: We conclude that CSF-NFL may mirror the proposed slow axonal degeneration in PPMS, but does not reflect the disease severity.
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      – SubjectFull: neurofilament light chain (NFL)
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