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Oral Etoposide for Dengue Induced Haemophagocytic Lymphohistiocytosis Presented as Acute Liver Failure

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Title: Oral Etoposide for Dengue Induced Haemophagocytic Lymphohistiocytosis Presented as Acute Liver Failure
Authors: Bharat Patodiya, Souwmya Iyengar, Padaki Nagaraja Rao, Anuradha Sekaran, Duvvu Nageshwar Reddy Reddy
Source: Journal of Clinical and Diagnostic Research, Vol 16, Iss 9, Pp XD04-XD07 (2022)
Publisher Information: JCDR Research and Publications Private Limited, 2022.
Publication Year: 2022
Collection: LCC:Medicine
Subject Terms: chemotherapy, cytopenia, haemophagocytic syndrome, macrophage activation syndrome, Medicine
More Details: Dengue fever is not an uncommon arboviral infection in lieu of tropical geography. The gravity of the disease ranges from an Outpatient Department (OPD) visits for febrile illness to haemorrhagic complications like shock. Hereby, authors report a case of a 33-year-old female patient with no prior morbidities. Initial fever episodes due to dengue resulted but she deteriorated clinically with second wave of continuous fever spikes. On evaluation, a diagnosis of Haemophagocytic Lymphohistiocytosis (HLH) was made. The patient was treated with steroids and oral etoposide following which patient recovered completely. Although, scarce occurrence of HLH following viral illness needs strong suspicion, prompt investigation and management to avoid potentially life-threatening complications. On a case-to-case basis HLH protocol can be modified to make an OPD base treatment by switching to oral etoposide.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2249-782X
0973-709X
Relation: https://jcdr.net/articles/PDF/16945/56519_CE(AnK)_F[SH]_PF1(SC_OM)_PFA(Pr_KM)_PN(KM).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X
DOI: 10.7860/JCDR/2022/56519.16945
Access URL: https://doaj.org/article/74334d9b60494a17a69b1ce0a00e9e6a
Accession Number: edsdoj.74334d9b60494a17a69b1ce0a00e9e6a
Database: Directory of Open Access Journals
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  Data: Oral Etoposide for Dengue Induced Haemophagocytic Lymphohistiocytosis Presented as Acute Liver Failure
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  Data: <searchLink fieldCode="AR" term="%22Bharat+Patodiya%22">Bharat Patodiya</searchLink><br /><searchLink fieldCode="AR" term="%22Souwmya+Iyengar%22">Souwmya Iyengar</searchLink><br /><searchLink fieldCode="AR" term="%22Padaki+Nagaraja+Rao%22">Padaki Nagaraja Rao</searchLink><br /><searchLink fieldCode="AR" term="%22Anuradha+Sekaran%22">Anuradha Sekaran</searchLink><br /><searchLink fieldCode="AR" term="%22Duvvu+Nageshwar+Reddy+Reddy%22">Duvvu Nageshwar Reddy Reddy</searchLink>
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  Data: Journal of Clinical and Diagnostic Research, Vol 16, Iss 9, Pp XD04-XD07 (2022)
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  Data: JCDR Research and Publications Private Limited, 2022.
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  Data: 2022
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  Data: <searchLink fieldCode="DE" term="%22chemotherapy%22">chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22cytopenia%22">cytopenia</searchLink><br /><searchLink fieldCode="DE" term="%22haemophagocytic+syndrome%22">haemophagocytic syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22macrophage+activation+syndrome%22">macrophage activation syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
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  Group: Ab
  Data: Dengue fever is not an uncommon arboviral infection in lieu of tropical geography. The gravity of the disease ranges from an Outpatient Department (OPD) visits for febrile illness to haemorrhagic complications like shock. Hereby, authors report a case of a 33-year-old female patient with no prior morbidities. Initial fever episodes due to dengue resulted but she deteriorated clinically with second wave of continuous fever spikes. On evaluation, a diagnosis of Haemophagocytic Lymphohistiocytosis (HLH) was made. The patient was treated with steroids and oral etoposide following which patient recovered completely. Although, scarce occurrence of HLH following viral illness needs strong suspicion, prompt investigation and management to avoid potentially life-threatening complications. On a case-to-case basis HLH protocol can be modified to make an OPD base treatment by switching to oral etoposide.
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      – Text: English
    Subjects:
      – SubjectFull: chemotherapy
        Type: general
      – SubjectFull: cytopenia
        Type: general
      – SubjectFull: haemophagocytic syndrome
        Type: general
      – SubjectFull: macrophage activation syndrome
        Type: general
      – SubjectFull: Medicine
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      – TitleFull: Oral Etoposide for Dengue Induced Haemophagocytic Lymphohistiocytosis Presented as Acute Liver Failure
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            NameFull: Bharat Patodiya
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            NameFull: Duvvu Nageshwar Reddy Reddy
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