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Internalizing Symptoms and Their Impact on Patient-Reported Health-Related Quality of Life and Fatigue among Patients with Craniopharyngioma During Proton Radiation Therapy

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Title: Internalizing Symptoms and Their Impact on Patient-Reported Health-Related Quality of Life and Fatigue among Patients with Craniopharyngioma During Proton Radiation Therapy
Authors: Belinda N. Mandrell, Yian Guo, Yimei Li, Donna Hancock, Mary Caples, Jason M. Ashford, Thomas E. Merchant, Heather M. Conklin, Valerie Mc. Crabtree
Source: Children, Vol 11, Iss 10, p 1159 (2024)
Publisher Information: MDPI AG, 2024.
Publication Year: 2024
Collection: LCC:Pediatrics
Subject Terms: craniopharyngioma, proton therapy, internalizing behaviors, symptoms, latent class, Pediatrics, RJ1-570
More Details: Objective: The aim of this study was to describe fatigue, health-related quality of life (HRQOL) and brain tumor-associated symptoms after surgical resection and during proton radiotherapy, using latent class analysis (LCA), and to determine if there is class membership change among pediatric patients with craniopharyngioma. Methods: For all patients (n = 92), demographic and disease-related/clinical variables were attained, and patient reported outcomes were collected prior to proton therapy, at week three, and at the completion of proton therapy. The mean scores for fatigue, HRQOL, and brain tumor symptoms were compared over time and profiles were identified. Factors that influenced profile status and transition probability were examined. Results: Fatigue, HRQOL, and brain tumor symptoms improved over time during proton therapy; however, a subset remained in the lower profile, profile 1, associated with increased internalizing behaviors, compared to profile 2. Conclusions: Future study should explore the bidirectional relationship of sleep, worry and anxiety in the context of ongoing radiotherapy.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2227-9067
Relation: https://www.mdpi.com/2227-9067/11/10/1159; https://doaj.org/toc/2227-9067
DOI: 10.3390/children11101159
Access URL: https://doaj.org/article/a7194c333b824c138a4b3f408cba3606
Accession Number: edsdoj.7194c333b824c138a4b3f408cba3606
Database: Directory of Open Access Journals
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  Data: Internalizing Symptoms and Their Impact on Patient-Reported Health-Related Quality of Life and Fatigue among Patients with Craniopharyngioma During Proton Radiation Therapy
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  Data: <searchLink fieldCode="AR" term="%22Belinda+N%2E+Mandrell%22">Belinda N. Mandrell</searchLink><br /><searchLink fieldCode="AR" term="%22Yian+Guo%22">Yian Guo</searchLink><br /><searchLink fieldCode="AR" term="%22Yimei+Li%22">Yimei Li</searchLink><br /><searchLink fieldCode="AR" term="%22Donna+Hancock%22">Donna Hancock</searchLink><br /><searchLink fieldCode="AR" term="%22Mary+Caples%22">Mary Caples</searchLink><br /><searchLink fieldCode="AR" term="%22Jason+M%2E+Ashford%22">Jason M. Ashford</searchLink><br /><searchLink fieldCode="AR" term="%22Thomas+E%2E+Merchant%22">Thomas E. Merchant</searchLink><br /><searchLink fieldCode="AR" term="%22Heather+M%2E+Conklin%22">Heather M. Conklin</searchLink><br /><searchLink fieldCode="AR" term="%22Valerie+Mc%2E+Crabtree%22">Valerie Mc. Crabtree</searchLink>
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  Data: Children, Vol 11, Iss 10, p 1159 (2024)
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  Data: <searchLink fieldCode="DE" term="%22craniopharyngioma%22">craniopharyngioma</searchLink><br /><searchLink fieldCode="DE" term="%22proton+therapy%22">proton therapy</searchLink><br /><searchLink fieldCode="DE" term="%22internalizing+behaviors%22">internalizing behaviors</searchLink><br /><searchLink fieldCode="DE" term="%22symptoms%22">symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22latent+class%22">latent class</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatrics%22">Pediatrics</searchLink><br /><searchLink fieldCode="DE" term="%22RJ1-570%22">RJ1-570</searchLink>
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  Data: Objective: The aim of this study was to describe fatigue, health-related quality of life (HRQOL) and brain tumor-associated symptoms after surgical resection and during proton radiotherapy, using latent class analysis (LCA), and to determine if there is class membership change among pediatric patients with craniopharyngioma. Methods: For all patients (n = 92), demographic and disease-related/clinical variables were attained, and patient reported outcomes were collected prior to proton therapy, at week three, and at the completion of proton therapy. The mean scores for fatigue, HRQOL, and brain tumor symptoms were compared over time and profiles were identified. Factors that influenced profile status and transition probability were examined. Results: Fatigue, HRQOL, and brain tumor symptoms improved over time during proton therapy; however, a subset remained in the lower profile, profile 1, associated with increased internalizing behaviors, compared to profile 2. Conclusions: Future study should explore the bidirectional relationship of sleep, worry and anxiety in the context of ongoing radiotherapy.
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      – SubjectFull: proton therapy
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