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Hepatitis B antibody titers in Indonesian adolescents who received the primary hepatitis B vaccine during infancy

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Title: Hepatitis B antibody titers in Indonesian adolescents who received the primary hepatitis B vaccine during infancy
Authors: Hartono Gunardi, Adra Firmansyah, Sri Rezeki S Harun, Sudigdo Sastroasmoro
Source: Paediatrica Indonesiana, Vol 53, Iss 3, Pp 160-6 (2013)
Publisher Information: Indonesian Pediatric Society Publishing House, 2013.
Publication Year: 2013
Collection: LCC:Medicine
LCC:Pediatrics
Subject Terms: adolescent, anti-HBs , booster, hepatitis B vaccine, immunity, Medicine, Pediatrics, RJ1-570
More Details: Backgi-ound Hepatitis B (HB) has been classified as moderate-tohighly endemic in Indonesia. HB vaccination, the most effective method to prevent HB viral transmission, induces protective antibodies against HB surface antigen (anti-HBs). However, these antibodies decline in titer over time. Studies on the duration of protection and the prevalence of n on-responders in Indonesian adolescents have been limited. Objectives To determine anti-HBs titers in 15-17-year old Indonesian adolescents given primary HB vaccine during infancy and the prevalence of non-responders after a HB vaccine booster dosage. Methods This cross-sectional study was performed from February to September 2008 on adolescents aged 15-17 years in three senior high schools in Jakarta who received complete primary HB vaccines during infancy, based on parents' recall. Investigations included HB vaccination history, anthropometric measurements, and blood tests for anti-HBs before and 4-6 weeks after a booster dose ofHB vaccine. Results Of 94 subjects, 35 had protective anti-HBs and 59 had undetectable anti-HBs. A booster dose was administered to 5 8 of the n on-protected subjects, of which 33 showed anamnestic responses. However, 25 subjects failed to generate protective anti-HBs. Taking into consideration the adolescents with protective anti-HBs before and after the booster dose, serologic protection was demonstrated in 73%. Non-responder prevalence was 27%. The high prevalence of non-responders may indicate bias of parents' recall. Conclusion Protective anti-HBs is detected in less than half of Indonesian adolescents given primary HB vaccine during infancy. Following booster dosage, anamnestic responses are n oted in onethird of subjects. The prevalence of non-responders is 27%, but confirmation with further study is needed.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 0030-9311
2338-476X
Relation: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/274; https://doaj.org/toc/0030-9311; https://doaj.org/toc/2338-476X
DOI: 10.14238/pi53.3.2013.160-6
Access URL: https://doaj.org/article/6dd53f139e474a2cad5e8b1ec2eb8448
Accession Number: edsdoj.6dd53f139e474a2cad5e8b1ec2eb8448
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  Data: Hepatitis B antibody titers in Indonesian adolescents who received the primary hepatitis B vaccine during infancy
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  Data: <searchLink fieldCode="AR" term="%22Hartono+Gunardi%22">Hartono Gunardi</searchLink><br /><searchLink fieldCode="AR" term="%22Adra+Firmansyah%22">Adra Firmansyah</searchLink><br /><searchLink fieldCode="AR" term="%22Sri+Rezeki+S+Harun%22">Sri Rezeki S Harun</searchLink><br /><searchLink fieldCode="AR" term="%22Sudigdo+Sastroasmoro%22">Sudigdo Sastroasmoro</searchLink>
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  Data: Paediatrica Indonesiana, Vol 53, Iss 3, Pp 160-6 (2013)
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  Data: Indonesian Pediatric Society Publishing House, 2013.
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  Data: 2013
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  Data: LCC:Medicine<br />LCC:Pediatrics
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  Label: Description
  Group: Ab
  Data: Backgi-ound Hepatitis B (HB) has been classified as moderate-tohighly endemic in Indonesia. HB vaccination, the most effective method to prevent HB viral transmission, induces protective antibodies against HB surface antigen (anti-HBs). However, these antibodies decline in titer over time. Studies on the duration of protection and the prevalence of n on-responders in Indonesian adolescents have been limited. Objectives To determine anti-HBs titers in 15-17-year old Indonesian adolescents given primary HB vaccine during infancy and the prevalence of non-responders after a HB vaccine booster dosage. Methods This cross-sectional study was performed from February to September 2008 on adolescents aged 15-17 years in three senior high schools in Jakarta who received complete primary HB vaccines during infancy, based on parents' recall. Investigations included HB vaccination history, anthropometric measurements, and blood tests for anti-HBs before and 4-6 weeks after a booster dose ofHB vaccine. Results Of 94 subjects, 35 had protective anti-HBs and 59 had undetectable anti-HBs. A booster dose was administered to 5 8 of the n on-protected subjects, of which 33 showed anamnestic responses. However, 25 subjects failed to generate protective anti-HBs. Taking into consideration the adolescents with protective anti-HBs before and after the booster dose, serologic protection was demonstrated in 73%. Non-responder prevalence was 27%. The high prevalence of non-responders may indicate bias of parents' recall. Conclusion Protective anti-HBs is detected in less than half of Indonesian adolescents given primary HB vaccine during infancy. Following booster dosage, anamnestic responses are n oted in onethird of subjects. The prevalence of non-responders is 27%, but confirmation with further study is needed.
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  Data: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/274; https://doaj.org/toc/0030-9311; https://doaj.org/toc/2338-476X
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