Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial
| Title: | Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial |
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| Authors: | Chen H, Zhi J, Wang L, Jin Z, Xu J, Xing F, Wen C, Wang Q, Chen C, Li W, Xu E, An J, Wei L |
| Source: | Drug Design, Development and Therapy, Vol Volume 18, Pp 3645-3658 (2024) |
| Publisher Information: | Dove Medical Press, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | esketamine, sedation, analgesia, satisfaction, liposuction, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Haotian Chen, Juan Zhi, Lei Wang, Zibin Jin, Jin Xu, Fei Xing, Chao Wen, Qianyu Wang, Chunmei Chen, Weiou Li, Ermeng Xu, Jie An, Lingxin Wei Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Lingxin Wei, Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People’s Republic of China, Tel +86 010 85557917, Email weilx3934@sina.comPurpose: Esketamine have anesthetic and analgesic properties. This study aimed to observe the enhancing effect of subanesthetic doses of esketamine (0.15– 0.3 mg/kg/h) with dexmedetomidine and remifentanil during anesthesia for liposuction surgery.Patients and Methods: A total of 155 subjects were randomized with a 1:1 ratio to Group E (esketamine-dexmedetomidine/remifentanil, n=78) or Group C (saline-dexmedetomidine/remifentanil group, n=77). The primary outcome was satisfaction of patient and surgical team with the procedure. The secondary outcomes were the postoperative Athens Insomnia Scale (AIS) and Hospital Anxiety and Depression Scale (HADS) scores, hemodynamic and respiratory changes, drug consumption, adverse event rates, and predictors associated with patient satisfaction.Results: Patient and surgical team satisfaction with the procedure was significantly higher in Group E than in Group C (4.7 ± 0.6 vs 4.2 ± 0.7, P < 0.001; 4.7 ± 0.5 vs 4.4 ± 0.7, P = 0.005). The postoperative AIS (4 [1, 6] vs 5 [2, 9], P = 0.012) and HADS-A (1 [0, 3] vs 2 [0, 6], P = 0.012) scores were significantly lower in Group E than in Group C. Hemodynamic and respiratory parameters were more stable in Group E than in Group C, with the lower opioids consumption of sufentanil (0 [0, 4] vs 5 [2.5, 7.7], P < 0.001) and remifentanil (700 [480, 900] vs 800 [500, 1200], P = 0.023) in Group E compared to Group C. On ordinal logistics regression, postoperative sleep quality (OR, 0.70; 95% CI, 0.62– 0.79), anxiety level (OR, 0.77; 95% CI, 0.62– 0.95) and recovery time in post-anesthesia care unit (PACU) (OR, 0.69; 95% CI, 0.56– 0.98) were identified as significant predictors associated with patient satisfaction.Conclusion: A subanesthetic dose of esketamine (0.15– 0.3 mg/kg/h) as an adjuvant can improves the sedative and analgesic effects of dexmedetomidine and remifentanil during anesthesia for liposuction surgery.Clinical Trial Registration: ChiCTR2400080363.Keywords: esketamine, sedation, analgesia, satisfaction, liposuction |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1177-8881 |
| Relation: | https://www.dovepress.com/subanesthetic-dose-of-esketamine-improves-the-sedative-and-analgesic-e-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881 |
| Access URL: | https://doaj.org/article/6d428523042b4c4bad31b216e0543488 |
| Accession Number: | edsdoj.6d428523042b4c4bad31b216e0543488 |
| Database: | Directory of Open Access Journals |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=11778881&ISBN=&volume=ume%2018&issue=&date=20240801&spage=3645&pages=3645-3658&title=Drug Design, Development and Therapy&atitle=Subanesthetic%20Dose%20of%20Esketamine%20Improves%20the%20Sedative%20and%20Analgesic%20Effects%20of%20Dexmedetomidine%20and%20Remifentanil%20in%20Liposuction%20Anesthesia%3A%20A%20Prospective%2C%20Double-Blinded%2C%20Randomized%20Controlled%20Trial&aulast=Chen%20H&id=DOI: Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries – Url: https://doaj.org/article/6d428523042b4c4bad31b216e0543488 Name: EDS - DOAJ (s8985755) Category: fullText Text: View record from DOAJ MouseOverText: View record from DOAJ |
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| Header | DbId: edsdoj DbLabel: Directory of Open Access Journals An: edsdoj.6d428523042b4c4bad31b216e0543488 RelevancyScore: 1047 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1047.24206542969 |
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| Items | – Name: Title Label: Title Group: Ti Data: Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen+H%22">Chen H</searchLink><br /><searchLink fieldCode="AR" term="%22Zhi+J%22">Zhi J</searchLink><br /><searchLink fieldCode="AR" term="%22Wang+L%22">Wang L</searchLink><br /><searchLink fieldCode="AR" term="%22Jin+Z%22">Jin Z</searchLink><br /><searchLink fieldCode="AR" term="%22Xu+J%22">Xu J</searchLink><br /><searchLink fieldCode="AR" term="%22Xing+F%22">Xing F</searchLink><br /><searchLink fieldCode="AR" term="%22Wen+C%22">Wen C</searchLink><br /><searchLink fieldCode="AR" term="%22Wang+Q%22">Wang Q</searchLink><br /><searchLink fieldCode="AR" term="%22Chen+C%22">Chen C</searchLink><br /><searchLink fieldCode="AR" term="%22Li+W%22">Li W</searchLink><br /><searchLink fieldCode="AR" term="%22Xu+E%22">Xu E</searchLink><br /><searchLink fieldCode="AR" term="%22An+J%22">An J</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+L%22">Wei L</searchLink> – Name: TitleSource Label: Source Group: Src Data: Drug Design, Development and Therapy, Vol Volume 18, Pp 3645-3658 (2024) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Dove Medical Press, 2024. – Name: DatePubCY Label: Publication Year Group: Date Data: 2024 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Therapeutics. Pharmacology – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22esketamine%22">esketamine</searchLink><br /><searchLink fieldCode="DE" term="%22sedation%22">sedation</searchLink><br /><searchLink fieldCode="DE" term="%22analgesia%22">analgesia</searchLink><br /><searchLink fieldCode="DE" term="%22satisfaction%22">satisfaction</searchLink><br /><searchLink fieldCode="DE" term="%22liposuction%22">liposuction</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink> – Name: Abstract Label: Description Group: Ab Data: Haotian Chen, Juan Zhi, Lei Wang, Zibin Jin, Jin Xu, Fei Xing, Chao Wen, Qianyu Wang, Chunmei Chen, Weiou Li, Ermeng Xu, Jie An, Lingxin Wei Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Lingxin Wei, Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing, 100144, People’s Republic of China, Tel +86 010 85557917, Email weilx3934@sina.comPurpose: Esketamine have anesthetic and analgesic properties. This study aimed to observe the enhancing effect of subanesthetic doses of esketamine (0.15– 0.3 mg/kg/h) with dexmedetomidine and remifentanil during anesthesia for liposuction surgery.Patients and Methods: A total of 155 subjects were randomized with a 1:1 ratio to Group E (esketamine-dexmedetomidine/remifentanil, n=78) or Group C (saline-dexmedetomidine/remifentanil group, n=77). The primary outcome was satisfaction of patient and surgical team with the procedure. The secondary outcomes were the postoperative Athens Insomnia Scale (AIS) and Hospital Anxiety and Depression Scale (HADS) scores, hemodynamic and respiratory changes, drug consumption, adverse event rates, and predictors associated with patient satisfaction.Results: Patient and surgical team satisfaction with the procedure was significantly higher in Group E than in Group C (4.7 ± 0.6 vs 4.2 ± 0.7, P < 0.001; 4.7 ± 0.5 vs 4.4 ± 0.7, P = 0.005). The postoperative AIS (4 [1, 6] vs 5 [2, 9], P = 0.012) and HADS-A (1 [0, 3] vs 2 [0, 6], P = 0.012) scores were significantly lower in Group E than in Group C. Hemodynamic and respiratory parameters were more stable in Group E than in Group C, with the lower opioids consumption of sufentanil (0 [0, 4] vs 5 [2.5, 7.7], P < 0.001) and remifentanil (700 [480, 900] vs 800 [500, 1200], P = 0.023) in Group E compared to Group C. On ordinal logistics regression, postoperative sleep quality (OR, 0.70; 95% CI, 0.62– 0.79), anxiety level (OR, 0.77; 95% CI, 0.62– 0.95) and recovery time in post-anesthesia care unit (PACU) (OR, 0.69; 95% CI, 0.56– 0.98) were identified as significant predictors associated with patient satisfaction.Conclusion: A subanesthetic dose of esketamine (0.15– 0.3 mg/kg/h) as an adjuvant can improves the sedative and analgesic effects of dexmedetomidine and remifentanil during anesthesia for liposuction surgery.Clinical Trial Registration: ChiCTR2400080363.Keywords: esketamine, sedation, analgesia, satisfaction, liposuction – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1177-8881 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.dovepress.com/subanesthetic-dose-of-esketamine-improves-the-sedative-and-analgesic-e-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/6d428523042b4c4bad31b216e0543488" linkWindow="_blank">https://doaj.org/article/6d428523042b4c4bad31b216e0543488</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.6d428523042b4c4bad31b216e0543488 |
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| RecordInfo | BibRecord: BibEntity: Languages: – Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 3645 Subjects: – SubjectFull: esketamine Type: general – SubjectFull: sedation Type: general – SubjectFull: analgesia Type: general – SubjectFull: satisfaction Type: general – SubjectFull: liposuction Type: general – SubjectFull: Therapeutics. Pharmacology Type: general – SubjectFull: RM1-950 Type: general Titles: – TitleFull: Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen H – PersonEntity: Name: NameFull: Zhi J – PersonEntity: Name: NameFull: Wang L – PersonEntity: Name: NameFull: Jin Z – PersonEntity: Name: NameFull: Xu J – PersonEntity: Name: NameFull: Xing F – PersonEntity: Name: NameFull: Wen C – PersonEntity: Name: NameFull: Wang Q – PersonEntity: Name: NameFull: Chen C – PersonEntity: Name: NameFull: Li W – PersonEntity: Name: NameFull: Xu E – PersonEntity: Name: NameFull: An J – PersonEntity: Name: NameFull: Wei L IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 11778881 Numbering: – Type: volume Value: ume 18 Titles: – TitleFull: Drug Design, Development and Therapy Type: main |
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