Academic Journal
View in EDS
Linked Full Text

p85β regulates autophagic degradation of AXL to activate oncogenic signaling

Bibliographic Details
Title: p85β regulates autophagic degradation of AXL to activate oncogenic signaling
Authors: Ling Rao, Victor C. Y. Mak, Yuan Zhou, Dong Zhang, Xinran Li, Chloe C. Y. Fung, Rakesh Sharma, Chao Gu, Yiling Lu, George L. Tipoe, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Publisher Information: Nature Portfolio, 2020.
Publication Year: 2020
Collection: LCC:Science
Subject Terms: Science
More Details: p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-020-16061-7
Access URL: https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
Accession Number: edsdoj.6777a01c94b29a362d31af3cc89e0
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4974AD972A50867CE1AB&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://login.libproxy.scu.edu/login?url=http://www.nature.com/openurl?genre=article&title=Nature%20Communications&volume=11&issue=1&spage=1
    Name: Nature Publishing
    Category: fullText
    Text: Full Text from Nature Publishing
    MouseOverText: Full Text from Nature Publishing
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20411723&ISBN=&volume=11&issue=1&date=20200501&spage=1&pages=1-15&title=Nature Communications&atitle=p85%CE%B2%20regulates%20autophagic%20degradation%20of%20AXL%20to%20activate%20oncogenic%20signaling&aulast=Ling%20Rao&id=DOI:10.1038/s41467-020-16061-7
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.6777a01c94b29a362d31af3cc89e0
RelevancyScore: 943
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 942.669494628906
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: p85β regulates autophagic degradation of AXL to activate oncogenic signaling
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ling+Rao%22">Ling Rao</searchLink><br /><searchLink fieldCode="AR" term="%22Victor+C%2E+Y%2E+Mak%22">Victor C. Y. Mak</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan+Zhou%22">Yuan Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Dong+Zhang%22">Dong Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Xinran+Li%22">Xinran Li</searchLink><br /><searchLink fieldCode="AR" term="%22Chloe+C%2E+Y%2E+Fung%22">Chloe C. Y. Fung</searchLink><br /><searchLink fieldCode="AR" term="%22Rakesh+Sharma%22">Rakesh Sharma</searchLink><br /><searchLink fieldCode="AR" term="%22Chao+Gu%22">Chao Gu</searchLink><br /><searchLink fieldCode="AR" term="%22Yiling+Lu%22">Yiling Lu</searchLink><br /><searchLink fieldCode="AR" term="%22George+L%2E+Tipoe%22">George L. Tipoe</searchLink><br /><searchLink fieldCode="AR" term="%22Annie+N%2E+Y%2E+Cheung%22">Annie N. Y. Cheung</searchLink><br /><searchLink fieldCode="AR" term="%22Gordon+B%2E+Mills%22">Gordon B. Mills</searchLink><br /><searchLink fieldCode="AR" term="%22Lydia+W%2E+T%2E+Cheung%22">Lydia W. T. Cheung</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Nature Portfolio, 2020.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2020
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2041-1723
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2041-1723
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41467-020-16061-7
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0" linkWindow="_blank">https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.6777a01c94b29a362d31af3cc89e0
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.6777a01c94b29a362d31af3cc89e0
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-020-16061-7
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 1
    Subjects:
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: p85β regulates autophagic degradation of AXL to activate oncogenic signaling
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ling Rao
      – PersonEntity:
          Name:
            NameFull: Victor C. Y. Mak
      – PersonEntity:
          Name:
            NameFull: Yuan Zhou
      – PersonEntity:
          Name:
            NameFull: Dong Zhang
      – PersonEntity:
          Name:
            NameFull: Xinran Li
      – PersonEntity:
          Name:
            NameFull: Chloe C. Y. Fung
      – PersonEntity:
          Name:
            NameFull: Rakesh Sharma
      – PersonEntity:
          Name:
            NameFull: Chao Gu
      – PersonEntity:
          Name:
            NameFull: Yiling Lu
      – PersonEntity:
          Name:
            NameFull: George L. Tipoe
      – PersonEntity:
          Name:
            NameFull: Annie N. Y. Cheung
      – PersonEntity:
          Name:
            NameFull: Gordon B. Mills
      – PersonEntity:
          Name:
            NameFull: Lydia W. T. Cheung
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 20411723
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature Communications
              Type: main
ResultId 1