Functional clustering of dendritic activity during decision-making

Bibliographic Details
Title:	Functional clustering of dendritic activity during decision-making
Authors:	Aaron Kerlin, Boaz Mohar, Daniel Flickinger, Bryan J MacLennan, Matthew B Dean, Courtney Davis, Nelson Spruston, Karel Svoboda
Source:	eLife, Vol 8 (2019)
Publisher Information:	eLife Sciences Publications Ltd, 2019.
Publication Year:	2019
Collection:	LCC:Medicine LCC:Science LCC:Biology (General)
Subject Terms:	dendritic spines, motor preparation, calcium imaging, in vivo imaging, Medicine, Science, Biology (General), QH301-705.5
More Details:	The active properties of dendrites can support local nonlinear operations, but previous imaging and electrophysiological measurements have produced conflicting views regarding the prevalence and selectivity of local nonlinearities in vivo. We imaged calcium signals in pyramidal cell dendrites in the motor cortex of mice performing a tactile decision task. A custom microscope allowed us to image the soma and up to 300 μm of contiguous dendrite at 15 Hz, while resolving individual spines. New analysis methods were used to estimate the frequency and spatial scales of activity in dendritic branches and spines. The majority of dendritic calcium transients were coincident with global events. However, task-associated calcium signals in dendrites and spines were compartmentalized by dendritic branching and clustered within branches over approximately 10 μm. Diverse behavior-related signals were intermingled and distributed throughout the dendritic arbor, potentially supporting a large learning capacity in individual neurons.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2050-084X
Relation:	https://elifesciences.org/articles/46966; https://doaj.org/toc/2050-084X
DOI:	10.7554/eLife.46966
Access URL:	https://doaj.org/article/64ae45c3401d43e1bc24f08fd05eb553
Accession Number:	edsdoj.64ae45c3401d43e1bc24f08fd05eb553
Database:	Directory of Open Access Journals

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RecordInfo	BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7554/eLife.46966 Languages: – Text: English Subjects: – SubjectFull: dendritic spines Type: general – SubjectFull: motor preparation Type: general – SubjectFull: calcium imaging Type: general – SubjectFull: in vivo imaging Type: general – SubjectFull: Medicine Type: general – SubjectFull: Science Type: general – SubjectFull: Biology (General) Type: general – SubjectFull: QH301-705.5 Type: general Titles: – TitleFull: Functional clustering of dendritic activity during decision-making Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aaron Kerlin – PersonEntity: Name: NameFull: Boaz Mohar – PersonEntity: Name: NameFull: Daniel Flickinger – PersonEntity: Name: NameFull: Bryan J MacLennan – PersonEntity: Name: NameFull: Matthew B Dean – PersonEntity: Name: NameFull: Courtney Davis – PersonEntity: Name: NameFull: Nelson Spruston – PersonEntity: Name: NameFull: Karel Svoboda IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 2050084X Numbering: – Type: volume Value: 8 Titles: – TitleFull: eLife Type: main
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