Academic Journal
Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
| Title: | Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia |
|---|---|
| Authors: | Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth Cordell, Xia Ge, Joel R. Garbow, Michael J. Holtzman, David H. Gutmann |
| Source: | Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| More Details: | Clinical studies have suggested a reduced incidence of brain tumors, including optic gliomas, in children with asthma. Here, in a mouse model of Neurofibromatosis type 1 associated low grade optic glioma, the authors show that experimental asthma induction decreases glioma formation and growth, resulting from T cell-dependent inhibition of microglia-mediated tumor support. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-021-27455-6 |
| Access URL: | https://doaj.org/article/e627dfd988e34a69a26d27c59e8d639b |
| Accession Number: | edsdoj.627dfd988e34a69a26d27c59e8d639b |
| Database: | Directory of Open Access Journals |
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