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Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

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Title: Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
Authors: Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth Cordell, Xia Ge, Joel R. Garbow, Michael J. Holtzman, David H. Gutmann
Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publisher Information: Nature Portfolio, 2021.
Publication Year: 2021
Collection: LCC:Science
Subject Terms: Science
More Details: Clinical studies have suggested a reduced incidence of brain tumors, including optic gliomas, in children with asthma. Here, in a mouse model of Neurofibromatosis type 1 associated low grade optic glioma, the authors show that experimental asthma induction decreases glioma formation and growth, resulting from T cell-dependent inhibition of microglia-mediated tumor support.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-021-27455-6
Access URL: https://doaj.org/article/e627dfd988e34a69a26d27c59e8d639b
Accession Number: edsdoj.627dfd988e34a69a26d27c59e8d639b
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Jit+Chatterjee%22">Jit Chatterjee</searchLink><br /><searchLink fieldCode="AR" term="%22Shilpa+Sanapala%22">Shilpa Sanapala</searchLink><br /><searchLink fieldCode="AR" term="%22Olivia+Cobb%22">Olivia Cobb</searchLink><br /><searchLink fieldCode="AR" term="%22Alice+Bewley%22">Alice Bewley</searchLink><br /><searchLink fieldCode="AR" term="%22Andrea+K%2E+Goldstein%22">Andrea K. Goldstein</searchLink><br /><searchLink fieldCode="AR" term="%22Elizabeth+Cordell%22">Elizabeth Cordell</searchLink><br /><searchLink fieldCode="AR" term="%22Xia+Ge%22">Xia Ge</searchLink><br /><searchLink fieldCode="AR" term="%22Joel+R%2E+Garbow%22">Joel R. Garbow</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+J%2E+Holtzman%22">Michael J. Holtzman</searchLink><br /><searchLink fieldCode="AR" term="%22David+H%2E+Gutmann%22">David H. Gutmann</searchLink>
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  Data: Clinical studies have suggested a reduced incidence of brain tumors, including optic gliomas, in children with asthma. Here, in a mouse model of Neurofibromatosis type 1 associated low grade optic glioma, the authors show that experimental asthma induction decreases glioma formation and growth, resulting from T cell-dependent inhibition of microglia-mediated tumor support.
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