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Prediction of Prostate Cancer Risk Stratification Based on A Nonlinear Transformation Stacking Learning Strategy

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Title: Prediction of Prostate Cancer Risk Stratification Based on A Nonlinear Transformation Stacking Learning Strategy
Authors: Xinyu Cao, Yin Fang, Chunguang Yang, Zhenghao Liu, Guoping Xu, Yan Jiang, Peiyan Wu, Wenbo Song, Hanshuo Xing, Xinglong Wu
Source: International Neurourology Journal, Vol 28, Iss 1, Pp 33-43 (2024)
Publisher Information: Korean Continence Society, 2024.
Publication Year: 2024
Collection: LCC:Diseases of the genitourinary system. Urology
Subject Terms: prostatic neoplasms, risk stratification, machine learning, stacking learning, artificial intelligence, Diseases of the genitourinary system. Urology, RC870-923
More Details: Purpose Prostate cancer (PCa) is an epithelial malignancy that originates in the prostate gland and is generally categorized into low, intermediate, and high-risk groups. The primary diagnostic indicator for PCa is the measurement of serum prostate-specific antigen (PSA) values. However, reliance on PSA levels can result in false positives, leading to unnecessary biopsies and an increased risk of invasive injuries. Therefore, it is imperative to develop an efficient and accurate method for PCa risk stratification. Many recent studies on PCa risk stratification based on clinical data have employed a binary classification, distinguishing between low to intermediate and high risk. In this paper, we propose a novel machine learning (ML) approach utilizing a stacking learning strategy for predicting the tripartite risk stratification of PCa. Methods Clinical records, featuring attributes selected using the lasso method, were utilized with 5 ML classifiers. The outputs of these classifiers underwent transformation by various nonlinear transformers and were then concatenated with the lasso-selected features, resulting in a set of new features. A stacking learning strategy, integrating different ML classifiers, was developed based on these new features. Results Our proposed approach demonstrated superior performance, achieving an accuracy of 0.83 and an area under the receiver operating characteristic curve value of 0.88 in a dataset comprising 197 PCa patients with 42 clinical characteristics. Conclusions This study aimed to improve clinicians’ ability to rapidly assess PCa risk stratification while reducing the burden on patients. This was achieved by using artificial intelligence-related technologies as an auxiliary method for diagnosing PCa.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2093-4777
2093-6931
Relation: http://einj.org/upload/pdf/inj-2346332-166.pdf; https://doaj.org/toc/2093-4777; https://doaj.org/toc/2093-6931
DOI: 10.5213/inj.2346332.166
Access URL: https://doaj.org/article/61d87dd01b8f40cba45f5d4af45dcf5a
Accession Number: edsdoj.61d87dd01b8f40cba45f5d4af45dcf5a
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  Data: <searchLink fieldCode="AR" term="%22Xinyu+Cao%22">Xinyu Cao</searchLink><br /><searchLink fieldCode="AR" term="%22Yin+Fang%22">Yin Fang</searchLink><br /><searchLink fieldCode="AR" term="%22Chunguang+Yang%22">Chunguang Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhenghao+Liu%22">Zhenghao Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Guoping+Xu%22">Guoping Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Yan+Jiang%22">Yan Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Peiyan+Wu%22">Peiyan Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Wenbo+Song%22">Wenbo Song</searchLink><br /><searchLink fieldCode="AR" term="%22Hanshuo+Xing%22">Hanshuo Xing</searchLink><br /><searchLink fieldCode="AR" term="%22Xinglong+Wu%22">Xinglong Wu</searchLink>
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  Data: International Neurourology Journal, Vol 28, Iss 1, Pp 33-43 (2024)
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  Data: Purpose Prostate cancer (PCa) is an epithelial malignancy that originates in the prostate gland and is generally categorized into low, intermediate, and high-risk groups. The primary diagnostic indicator for PCa is the measurement of serum prostate-specific antigen (PSA) values. However, reliance on PSA levels can result in false positives, leading to unnecessary biopsies and an increased risk of invasive injuries. Therefore, it is imperative to develop an efficient and accurate method for PCa risk stratification. Many recent studies on PCa risk stratification based on clinical data have employed a binary classification, distinguishing between low to intermediate and high risk. In this paper, we propose a novel machine learning (ML) approach utilizing a stacking learning strategy for predicting the tripartite risk stratification of PCa. Methods Clinical records, featuring attributes selected using the lasso method, were utilized with 5 ML classifiers. The outputs of these classifiers underwent transformation by various nonlinear transformers and were then concatenated with the lasso-selected features, resulting in a set of new features. A stacking learning strategy, integrating different ML classifiers, was developed based on these new features. Results Our proposed approach demonstrated superior performance, achieving an accuracy of 0.83 and an area under the receiver operating characteristic curve value of 0.88 in a dataset comprising 197 PCa patients with 42 clinical characteristics. Conclusions This study aimed to improve clinicians’ ability to rapidly assess PCa risk stratification while reducing the burden on patients. This was achieved by using artificial intelligence-related technologies as an auxiliary method for diagnosing PCa.
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