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The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model

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Title: The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model
Authors: Yusuke Fukuo, Yoshihide Hattori, Shinji Kawabata, Hideki Kashiwagi, Takuya Kanemitsu, Koji Takeuchi, Gen Futamura, Ryo Hiramatsu, Tsubasa Watanabe, Naonori Hu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Shin-Ichi Miyatake, Mitsunori Kirihata, Masahiko Wanibuchi
Source: Biology, Vol 9, Iss 12, p 437 (2020)
Publisher Information: MDPI AG, 2020.
Publication Year: 2020
Collection: LCC:Biology (General)
Subject Terms: boron neutron capture therapy (BNCT), malignant glioma, survival prolongation, boronophenylalanine–amide alkyl dodecaborate (BADB), Biology (General), QH301-705.5
More Details: Background: The development of effective boron compounds is a major area of research in the study of boron neutron capture therapy (BNCT). We created a novel boron compound, boronophenylalanine–amide alkyl dodecaborate (BADB), for application in BNCT and focused on elucidating how it affected a rat brain tumor model. Methods: The boron concentration of F98 rat glioma cells following exposure to boronophenylalanine (BPA) (which is currently being utilized clinically) and BADB was evaluated, and the biodistributions in F98 glioma-bearing rats were assessed. In neutron irradiation studies, the in vitro cytotoxicity of each boron compound and the in vivo corresponding therapeutic effect were evaluated in terms of survival time. Results: The survival fractions of the groups irradiated with BPA and BADB were not significantly different. BADB administered for 6 h after the termination of convection-enhanced delivery ensured the highest boron concentration in the tumor (45.8 μg B/g). The median survival time in the BADB in combination with BPA group showed a more significant prolongation of survival than that of the BPA group. Conclusion: BADB is a novel boron compound for BNCT that triggers a prolonged survival effect in patients receiving BNCT.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2079-7737
Relation: https://www.mdpi.com/2079-7737/9/12/437; https://doaj.org/toc/2079-7737
DOI: 10.3390/biology9120437
Access URL: https://doaj.org/article/6032a14f3f784825b7d76a81461a3189
Accession Number: edsdoj.6032a14f3f784825b7d76a81461a3189
Database: Directory of Open Access Journals
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  Data: The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model
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  Data: <searchLink fieldCode="AR" term="%22Yusuke+Fukuo%22">Yusuke Fukuo</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshihide+Hattori%22">Yoshihide Hattori</searchLink><br /><searchLink fieldCode="AR" term="%22Shinji+Kawabata%22">Shinji Kawabata</searchLink><br /><searchLink fieldCode="AR" term="%22Hideki+Kashiwagi%22">Hideki Kashiwagi</searchLink><br /><searchLink fieldCode="AR" term="%22Takuya+Kanemitsu%22">Takuya Kanemitsu</searchLink><br /><searchLink fieldCode="AR" term="%22Koji+Takeuchi%22">Koji Takeuchi</searchLink><br /><searchLink fieldCode="AR" term="%22Gen+Futamura%22">Gen Futamura</searchLink><br /><searchLink fieldCode="AR" term="%22Ryo+Hiramatsu%22">Ryo Hiramatsu</searchLink><br /><searchLink fieldCode="AR" term="%22Tsubasa+Watanabe%22">Tsubasa Watanabe</searchLink><br /><searchLink fieldCode="AR" term="%22Naonori+Hu%22">Naonori Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Takushi+Takata%22">Takushi Takata</searchLink><br /><searchLink fieldCode="AR" term="%22Hiroki+Tanaka%22">Hiroki Tanaka</searchLink><br /><searchLink fieldCode="AR" term="%22Minoru+Suzuki%22">Minoru Suzuki</searchLink><br /><searchLink fieldCode="AR" term="%22Shin-Ichi+Miyatake%22">Shin-Ichi Miyatake</searchLink><br /><searchLink fieldCode="AR" term="%22Mitsunori+Kirihata%22">Mitsunori Kirihata</searchLink><br /><searchLink fieldCode="AR" term="%22Masahiko+Wanibuchi%22">Masahiko Wanibuchi</searchLink>
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  Data: Biology, Vol 9, Iss 12, p 437 (2020)
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  Data: MDPI AG, 2020.
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  Data: 2020
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  Data: <searchLink fieldCode="DE" term="%22boron+neutron+capture+therapy+%28BNCT%29%22">boron neutron capture therapy (BNCT)</searchLink><br /><searchLink fieldCode="DE" term="%22malignant+glioma%22">malignant glioma</searchLink><br /><searchLink fieldCode="DE" term="%22survival+prolongation%22">survival prolongation</searchLink><br /><searchLink fieldCode="DE" term="%22boronophenylalanine–amide+alkyl+dodecaborate+%28BADB%29%22">boronophenylalanine–amide alkyl dodecaborate (BADB)</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
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  Label: Description
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  Data: Background: The development of effective boron compounds is a major area of research in the study of boron neutron capture therapy (BNCT). We created a novel boron compound, boronophenylalanine–amide alkyl dodecaborate (BADB), for application in BNCT and focused on elucidating how it affected a rat brain tumor model. Methods: The boron concentration of F98 rat glioma cells following exposure to boronophenylalanine (BPA) (which is currently being utilized clinically) and BADB was evaluated, and the biodistributions in F98 glioma-bearing rats were assessed. In neutron irradiation studies, the in vitro cytotoxicity of each boron compound and the in vivo corresponding therapeutic effect were evaluated in terms of survival time. Results: The survival fractions of the groups irradiated with BPA and BADB were not significantly different. BADB administered for 6 h after the termination of convection-enhanced delivery ensured the highest boron concentration in the tumor (45.8 μg B/g). The median survival time in the BADB in combination with BPA group showed a more significant prolongation of survival than that of the BPA group. Conclusion: BADB is a novel boron compound for BNCT that triggers a prolonged survival effect in patients receiving BNCT.
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  Data: 10.3390/biology9120437
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      – SubjectFull: malignant glioma
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