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Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants

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Title: Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants
Authors: Gilead Ebiegberi Forcados, Aliyu Muhammad, Olusola Olalekan Oladipo, Sunday Makama, Clement Adebajo Meseko
Source: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Publisher Information: Frontiers Media S.A., 2021.
Publication Year: 2021
Collection: LCC:Microbiology
Subject Terms: COVID-19, oxidative stress, inflammation, therapeutics, antioxidants, Microbiology, QR1-502
More Details: COVID-19 is a zoonotic disease with devastating economic and public health impacts globally. Being a novel disease, current research is focused on a clearer understanding of the mechanisms involved in its pathogenesis and viable therapeutic strategies. Oxidative stress and inflammation are intertwined processes that play roles in disease progression and response to therapy via interference with multiple signaling pathways. The redox status of a host cell is an important factor in viral entry due to the unique conditions required for the conformational changes that ensure the binding and entry of a virus into the host cell. Upon entry into the airways, viral replication occurs and the innate immune system responds by activating macrophage and dendritic cells which contribute to inflammation. This review examines available literature and proposes mechanisms by which oxidative stress and inflammation could contribute to COVID-19 pathogenesis. Further, certain antioxidants currently undergoing some form of trial in COVID-19 patients and the corresponding required research gaps are highlighted to show how targeting oxidative stress and inflammation could ameliorate COVID-19 severity.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2235-2988
Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2021.654813/full; https://doaj.org/toc/2235-2988
DOI: 10.3389/fcimb.2021.654813
Access URL: https://doaj.org/article/c5eb9d2ff12e40da9373e5a9f13a7156
Accession Number: edsdoj.5eb9d2ff12e40da9373e5a9f13a7156
Database: Directory of Open Access Journals
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  Data: Metabolic Implications of Oxidative Stress and Inflammatory Process in SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants
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  Data: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
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  Data: COVID-19 is a zoonotic disease with devastating economic and public health impacts globally. Being a novel disease, current research is focused on a clearer understanding of the mechanisms involved in its pathogenesis and viable therapeutic strategies. Oxidative stress and inflammation are intertwined processes that play roles in disease progression and response to therapy via interference with multiple signaling pathways. The redox status of a host cell is an important factor in viral entry due to the unique conditions required for the conformational changes that ensure the binding and entry of a virus into the host cell. Upon entry into the airways, viral replication occurs and the innate immune system responds by activating macrophage and dendritic cells which contribute to inflammation. This review examines available literature and proposes mechanisms by which oxidative stress and inflammation could contribute to COVID-19 pathogenesis. Further, certain antioxidants currently undergoing some form of trial in COVID-19 patients and the corresponding required research gaps are highlighted to show how targeting oxidative stress and inflammation could ameliorate COVID-19 severity.
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      – Text: English
    Subjects:
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      – SubjectFull: oxidative stress
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      – SubjectFull: inflammation
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      – SubjectFull: therapeutics
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