Bibliographic Details
| Title: |
Association between increased serum interleukin-8 levels and improved cognition in major depressive patients with SSRIs |
| Authors: |
Yuan Cai, Zhen Hua Zhu, Rong Hua Li, Xu Yuan Yin, Ru Feng Chen, Li Juan Man, Wen Long Hou, Hong Liang Zhu, Jing Wang, Huiping Zhang, Qiu Fang Jia, Li Hui |
| Source: |
BMC Psychiatry, Vol 23, Iss 1, Pp 1-8 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Psychiatry |
| Subject Terms: |
Major depressive disorder, Interleukin-8, Cognitive function, SSRIs, Psychiatry, RC435-571 |
| More Details: |
Abstract Background The effect of neuroinflammatory cytokines on cognitive deficits in patients with major depressive disorder (MDD) can be altered by selective serotonin reuptake inhibitors (SSRIs). This study aimed to examine serum interleukin-8 (IL-8) levels, cognitive function, and their associations in MDD patients with SSRIs. Methods Thirty SSRI-treated MDD patients and 101 healthy controls were recruited for this study. We examined cognitive performance using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum IL-8 levels using the Human Inflammatory Cytokine Cytometric Bead Array in both cases and controls. Results The RBANS test scores were significantly lower in MDD patients with SSRIs than in healthy controls after controlling for covariates (all p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-244X |
| Relation: |
https://doaj.org/toc/1471-244X |
| DOI: |
10.1186/s12888-023-04616-z |
| Access URL: |
https://doaj.org/article/5a5d881ea0344e99a0203bfaaa0770aa |
| Accession Number: |
edsdoj.5a5d881ea0344e99a0203bfaaa0770aa |
| Database: |
Directory of Open Access Journals |
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