Bibliographic Details
| Title: |
Generation and characterization of iPSCs from a patient with obsessive–compulsive disorder, his mother with schizophrenia and his healthy father |
| Authors: |
Xu Yuan Yin, Zhen Hua Zhu, Ru Feng Chen, Jian Li, Guang Ya Zhang, Wen Long Hou, Nan Nan Zhuang, Yuan Cai, Ning Bin Dai, Fang Liu, Jing Wang, Qiu Fang Jia, Li Hui |
| Source: |
Stem Cell Research, Vol 66, Iss , Pp 102993- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Obsessive-compulsive disorder, Schizophrenia, Psychiatric disorders, Induced pluripotent stem cells (iPSCs), Biology (General), QH301-705.5 |
| More Details: |
Schizophrenia (SCZ) and obsessive–compulsive disorder (OCD) are complex polygenic disorders with brain morphology abnormalities. The etiologies and relationship of both disorders remain elusive, and should be further investigated. Thus, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) from an OCD patient, his mother with SCZ and his healthy father with reprograming method. All iPSCs were characterized to have normal karyotype and expression of pluripotency makers. These iPSCs will be a valuable model to elucidate the pathophysiological mechanisms and association of both diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1873-5061 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1873506122003427; https://doaj.org/toc/1873-5061 |
| DOI: |
10.1016/j.scr.2022.102993 |
| Access URL: |
https://doaj.org/article/55c486db2b6544fabfa35d5bb890f06a |
| Accession Number: |
edsdoj.55c486db2b6544fabfa35d5bb890f06a |
| Database: |
Directory of Open Access Journals |
