Academic Journal
View in EDS

Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review

Bibliographic Details
Title: Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review
Authors: Zachary Klaassen, Prakash R. Paragi, Ronald S. Chamberlain
Source: Case Reports in Gastroenterology, Vol 4, Iss 1, Pp 84-92 (2010)
Publisher Information: Karger Publishers, 2010.
Publication Year: 2010
Collection: LCC:Diseases of the digestive system. Gastroenterology
Subject Terms: Hepatic mass, Undifferentiated embryonal sarcoma, Mesenchymal hamartoma, Hepatobiliary surgery, Diseases of the digestive system. Gastroenterology, RC799-869
More Details: Mesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-year-old female was evaluated for an incidental liver mass. Initial CT scan showed a cystic lesion in the right lobe of the liver and follow-up imaging revealed an increase in size and the percent solid component within the mass. In view of these changes, a nondiagnostic biopsy was obtained followed by extirpation of the lesion. Gross pathological review of the lesion identified a 9 × 9 × 7.5 cm, pink-yellow-tan, gelatinous mass, with a >1 cm clear surgical margin. Histologically, the mass consisted of benign dilated bile ducts, as well as myxoid stroma with spindle cells showing smooth muscle differentiation. The patient was discharged home on postoperative day five. A review of the literature for MHL in adults reports 30 previous cases, predominantly published as individual case reports describing the size, lobe(s) of the liver affected, and the cystic/solid nature of the tumor. MHL in adults may represent a potentially premalignant lesion, as the emerging literature supports a potential relationship between MHL and malignant undifferentiated embryonal sarcoma in regards to cytogenetic analysis. Aggressive surgical management of MHL in adults is mandated when feasible.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1662-0631
00026018
52434249
Relation: http://www.karger.com/Article/FullText/260183; https://doaj.org/toc/1662-0631
DOI: 10.1159/000260183
Access URL: https://doaj.org/article/54656b52434249ca99f53f7213326c4b
Accession Number: edsdoj.54656b52434249ca99f53f7213326c4b
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=16620631&ISBN=&volume=4&issue=1&date=20100301&spage=84&pages=84-92&title=Case Reports in Gastroenterology&atitle=Adult%20Mesenchymal%20Hamartoma%20of%20the%20Liver%3A%20Case%20Report%20and%20Literature%20Review&aulast=Zachary%20Klaassen&id=DOI:10.1159/000260183
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/54656b52434249ca99f53f7213326c4b
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.54656b52434249ca99f53f7213326c4b
RelevancyScore: 866
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 866.350891113281
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zachary+Klaassen%22">Zachary Klaassen</searchLink><br /><searchLink fieldCode="AR" term="%22Prakash+R%2E+Paragi%22">Prakash R. Paragi</searchLink><br /><searchLink fieldCode="AR" term="%22Ronald+S%2E+Chamberlain%22">Ronald S. Chamberlain</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Case Reports in Gastroenterology, Vol 4, Iss 1, Pp 84-92 (2010)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Karger Publishers, 2010.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2010
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Diseases of the digestive system. Gastroenterology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hepatic+mass%22">Hepatic mass</searchLink><br /><searchLink fieldCode="DE" term="%22Undifferentiated+embryonal+sarcoma%22">Undifferentiated embryonal sarcoma</searchLink><br /><searchLink fieldCode="DE" term="%22Mesenchymal+hamartoma%22">Mesenchymal hamartoma</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatobiliary+surgery%22">Hepatobiliary surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+digestive+system%2E+Gastroenterology%22">Diseases of the digestive system. Gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22RC799-869%22">RC799-869</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Mesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-year-old female was evaluated for an incidental liver mass. Initial CT scan showed a cystic lesion in the right lobe of the liver and follow-up imaging revealed an increase in size and the percent solid component within the mass. In view of these changes, a nondiagnostic biopsy was obtained followed by extirpation of the lesion. Gross pathological review of the lesion identified a 9 × 9 × 7.5 cm, pink-yellow-tan, gelatinous mass, with a >1 cm clear surgical margin. Histologically, the mass consisted of benign dilated bile ducts, as well as myxoid stroma with spindle cells showing smooth muscle differentiation. The patient was discharged home on postoperative day five. A review of the literature for MHL in adults reports 30 previous cases, predominantly published as individual case reports describing the size, lobe(s) of the liver affected, and the cystic/solid nature of the tumor. MHL in adults may represent a potentially premalignant lesion, as the emerging literature supports a potential relationship between MHL and malignant undifferentiated embryonal sarcoma in regards to cytogenetic analysis. Aggressive surgical management of MHL in adults is mandated when feasible.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1662-0631<br />00026018<br />52434249
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://www.karger.com/Article/FullText/260183; https://doaj.org/toc/1662-0631
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1159/000260183
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/54656b52434249ca99f53f7213326c4b" linkWindow="_blank">https://doaj.org/article/54656b52434249ca99f53f7213326c4b</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.54656b52434249ca99f53f7213326c4b
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.54656b52434249ca99f53f7213326c4b
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1159/000260183
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 84
    Subjects:
      – SubjectFull: Hepatic mass
        Type: general
      – SubjectFull: Undifferentiated embryonal sarcoma
        Type: general
      – SubjectFull: Mesenchymal hamartoma
        Type: general
      – SubjectFull: Hepatobiliary surgery
        Type: general
      – SubjectFull: Diseases of the digestive system. Gastroenterology
        Type: general
      – SubjectFull: RC799-869
        Type: general
    Titles:
      – TitleFull: Adult Mesenchymal Hamartoma of the Liver: Case Report and Literature Review
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zachary Klaassen
      – PersonEntity:
          Name:
            NameFull: Prakash R. Paragi
      – PersonEntity:
          Name:
            NameFull: Ronald S. Chamberlain
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 16620631
            – Type: issn-print
              Value: 00026018
            – Type: issn-print
              Value: 52434249
          Numbering:
            – Type: volume
              Value: 4
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Case Reports in Gastroenterology
              Type: main
ResultId 1