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Preclinical translational research and application of tumor organoids

Bibliographic Details
Title: Preclinical translational research and application of tumor organoids
Authors: XIA Yujia, YANG Zhenli, LIU Yuqin
Source: Jichu yixue yu linchuang, Vol 44, Iss 9, Pp 1214-1218 (2024)
Publisher Information: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2024.
Publication Year: 2024
Collection: LCC:Medicine
Subject Terms: tumor organoid, precise treatment, organoid biobank, Medicine
More Details: More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied. This model is able to reproduce the genomic, transcriptome, proteome and other omics features of parental tumors without heterogeneity found in cell line models. Based on these characteristics, tumor organoids have gradually become a representative preclinical model, facilitating the translation of new research results and precision treatment of patients. This article summarizes the latest progress of tumor organoids on R&D of technology and application, focusing on the current methods of establishing tumor organoids, opportunities and challenges in clinical and research application.
Document Type: article
File Description: electronic resource
Language: Chinese
ISSN: 1001-6325
Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-9-1214.pdf; https://doaj.org/toc/1001-6325
DOI: 10.16352/j.issn.1001-6325.2024.09.1214
Access URL: https://doaj.org/article/53e531b73a5d4618addfb1c4def6ea2e
Accession Number: edsdoj.53e531b73a5d4618addfb1c4def6ea2e
Database: Directory of Open Access Journals
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  Data: Jichu yixue yu linchuang, Vol 44, Iss 9, Pp 1214-1218 (2024)
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  Data: More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied. This model is able to reproduce the genomic, transcriptome, proteome and other omics features of parental tumors without heterogeneity found in cell line models. Based on these characteristics, tumor organoids have gradually become a representative preclinical model, facilitating the translation of new research results and precision treatment of patients. This article summarizes the latest progress of tumor organoids on R&D of technology and application, focusing on the current methods of establishing tumor organoids, opportunities and challenges in clinical and research application.
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        PageCount: 5
        StartPage: 1214
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      – SubjectFull: tumor organoid
        Type: general
      – SubjectFull: precise treatment
        Type: general
      – SubjectFull: organoid biobank
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              Y: 2024
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