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Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism

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Title: Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism
Authors: Zitian Wang, Xue Zhao, Lifang Bu, Kun Liu, Ziping Li, Huaxing Zhang, Xiaoguang Zhang, Fang Yuan, Sheng Wang, Zan Guo, Luo Shi
Source: Frontiers in Physiology, Vol 14 (2023)
Publisher Information: Frontiers Media S.A., 2023.
Publication Year: 2023
Collection: LCC:Physiology
Subject Terms: primary aldosteronism, hypertension, left ventricular hypertrophy, low sodium, myocardial metabolic, Physiology, QP1-981
More Details: The goal of this paper is to elucidate the effects of sodium restriction on hypertension and left ventricular (LV) hypertrophy in a mouse model with primary aldosteronism (PA). Mice with genetic deletion of TWIK-related acid-sensitive K (TASK)-1 and TASK-3 channels (TASK−/−) were used as the animal model of PA. Parameters of the LV were assessed using echocardiography and histomorphology analysis. Untargeted metabolomics analysis was conducted to reveal the mechanisms underlying the hypertrophic changes in the TASK−/− mice. The TASK−/− adult male mice exhibited the hallmarks of PA, including hypertension, hyperaldosteronism, hypernatremia, hypokalemia, and mild acid-base balance disorders. Two weeks of low sodium intake significantly reduced the 24-h average systolic and diastolic BP in TASK−/− but not TASK+/+ mice. In addition, TASK−/− mice showed increasing LV hypertrophy with age, and 2 weeks of the low-sodium diet significantly reversed the increased BP and LV wall thickness in adult TASK−/− mice. Furthermore, a low-sodium diet beginning at 4 weeks of age protected TASK−/− mice from LV hypertrophy at 8–12 weeks of age. Untargeted metabolomics demonstrated that the disturbances in heart metabolism in the TASK−/− mice (e.g., Glutathione metabolism; biosynthesis of unsaturated fatty acids; amino sugar and nucleotide sugar metabolism; pantothenate and CoA biosynthesis; D-glutamine and D-glutamate metabolism), some of which were reversed after sodium restriction, might be involved in the development of LV hypertrophy. In conclusion, adult male TASK−/− mice exhibit spontaneous hypertension and LV hypertrophy, which are ameliorated by a low-sodium intake.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-042X
Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1136574/full; https://doaj.org/toc/1664-042X
DOI: 10.3389/fphys.2023.1136574
Access URL: https://doaj.org/article/53c7a200bdd34663925abd2a862eae02
Accession Number: edsdoj.53c7a200bdd34663925abd2a862eae02
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  Label: Title
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  Data: Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism
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  Data: <searchLink fieldCode="AR" term="%22Zitian+Wang%22">Zitian Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Xue+Zhao%22">Xue Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Lifang+Bu%22">Lifang Bu</searchLink><br /><searchLink fieldCode="AR" term="%22Kun+Liu%22">Kun Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Ziping+Li%22">Ziping Li</searchLink><br /><searchLink fieldCode="AR" term="%22Huaxing+Zhang%22">Huaxing Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoguang+Zhang%22">Xiaoguang Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Fang+Yuan%22">Fang Yuan</searchLink><br /><searchLink fieldCode="AR" term="%22Sheng+Wang%22">Sheng Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Zan+Guo%22">Zan Guo</searchLink><br /><searchLink fieldCode="AR" term="%22Luo+Shi%22">Luo Shi</searchLink>
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  Data: Frontiers in Physiology, Vol 14 (2023)
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  Data: Frontiers Media S.A., 2023.
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  Data: 2023
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  Data: <searchLink fieldCode="DE" term="%22primary+aldosteronism%22">primary aldosteronism</searchLink><br /><searchLink fieldCode="DE" term="%22hypertension%22">hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22left+ventricular+hypertrophy%22">left ventricular hypertrophy</searchLink><br /><searchLink fieldCode="DE" term="%22low+sodium%22">low sodium</searchLink><br /><searchLink fieldCode="DE" term="%22myocardial+metabolic%22">myocardial metabolic</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22QP1-981%22">QP1-981</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The goal of this paper is to elucidate the effects of sodium restriction on hypertension and left ventricular (LV) hypertrophy in a mouse model with primary aldosteronism (PA). Mice with genetic deletion of TWIK-related acid-sensitive K (TASK)-1 and TASK-3 channels (TASK−/−) were used as the animal model of PA. Parameters of the LV were assessed using echocardiography and histomorphology analysis. Untargeted metabolomics analysis was conducted to reveal the mechanisms underlying the hypertrophic changes in the TASK−/− mice. The TASK−/− adult male mice exhibited the hallmarks of PA, including hypertension, hyperaldosteronism, hypernatremia, hypokalemia, and mild acid-base balance disorders. Two weeks of low sodium intake significantly reduced the 24-h average systolic and diastolic BP in TASK−/− but not TASK+/+ mice. In addition, TASK−/− mice showed increasing LV hypertrophy with age, and 2 weeks of the low-sodium diet significantly reversed the increased BP and LV wall thickness in adult TASK−/− mice. Furthermore, a low-sodium diet beginning at 4 weeks of age protected TASK−/− mice from LV hypertrophy at 8–12 weeks of age. Untargeted metabolomics demonstrated that the disturbances in heart metabolism in the TASK−/− mice (e.g., Glutathione metabolism; biosynthesis of unsaturated fatty acids; amino sugar and nucleotide sugar metabolism; pantothenate and CoA biosynthesis; D-glutamine and D-glutamate metabolism), some of which were reversed after sodium restriction, might be involved in the development of LV hypertrophy. In conclusion, adult male TASK−/− mice exhibit spontaneous hypertension and LV hypertrophy, which are ameliorated by a low-sodium intake.
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        Value: 10.3389/fphys.2023.1136574
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      – Text: English
    Subjects:
      – SubjectFull: primary aldosteronism
        Type: general
      – SubjectFull: hypertension
        Type: general
      – SubjectFull: left ventricular hypertrophy
        Type: general
      – SubjectFull: low sodium
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      – SubjectFull: myocardial metabolic
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