Bibliographic Details
| Title: |
Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning |
| Authors: |
Pei-Chen Chen, Tzu-Pei Tsai, Yi-Chu Liao, Yu-Chieh Liao, Hung-Wei Cheng, Yi-Hsiu Weng, Chiao-Mei Lin, Cheng-Yuan Kao, Chih-Cheng Tai, Jhen-Wei Ruan |
| Source: |
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbial ecology |
| Subject Terms: |
Microbial ecology, QR100-130 |
| More Details: |
Abstract Gut microbiota rearrangement induced by cold temperature is crucial for browning in murine white adipose tissue. This study provides evidence that DUSP6, a host factor, plays a critical role in regulating cold-induced gut microbiota rearrangement. When exposed to cold, the downregulation of intestinal DUSP6 increased the capacity of gut microbiota to produce ursodeoxycholic acid (UDCA). The DUSP6-UDCA axis is essential for driving Lachnospiraceae expansion in the cold microbiota. In mice experiencing cold-room temperature (CR) transitions, prolonged DUSP6 inhibition via the DUSP6 inhibitor (E/Z)-BCI maintained increased cecal UDCA levels and cold-like microbiota networks. By analyzing DUSP6-regulated microbiota dynamics in cold-exposed mice, we identified Marvinbryantia as a genus whose abundance increased in response to cold exposure. When inoculated with human-origin Marvinbryantia formatexigens, germ-free recipient mice exhibited significantly enhanced browning phenotypes in white adipose tissue. Moreover, M. formatexigens secreted the methylated amino acid Nε-methyl-L-lysine, an enriched cecal metabolite in Dusp6 knockout mice that reduces adiposity and ameliorates nonalcoholic steatohepatitis in mice. Our work revealed that host-microbiota coadaptation to cold environments is essential for regulating the browning-promoting gut microbiome. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5008 |
| Relation: |
https://doaj.org/toc/2055-5008 |
| DOI: |
10.1038/s41522-024-00495-8 |
| Access URL: |
https://doaj.org/article/51ecacbb03f84f84a591fed8779acc1b |
| Accession Number: |
edsdoj.51ecacbb03f84f84a591fed8779acc1b |
| Database: |
Directory of Open Access Journals |
