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The inhibitory effect of cisplatin combined with tunicamycin on neuroblastoma and related mechanism

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Title: The inhibitory effect of cisplatin combined with tunicamycin on neuroblastoma and related mechanism
Authors: ZHANG Tenglong, SUN Wenjing, SONG Junying, HOU Lin
Source: 精准医学杂志, Vol 39, Iss 4, Pp 283-288 (2024)
Publisher Information: Editorial Office of Journal of Precision Medicine, 2024.
Publication Year: 2024
Collection: LCC:Medicine
Subject Terms: neuroblastoma, cisplatin, tunicamycin, janus kinase 2, stat3 transcription factor, hypoxia-inducible factor 1, alpha subunit, cell movement, cell proliferation, Medicine
More Details: Objective To investigate the inhibitory effect of cisplatin (DDP) combined with tunicamycin (TM) on human neuroblastoma SH-SY5Y and SK-N-SH cells and related mechanism. Methods Human neuroblastoma SH-SY5Y and SK-N-SH cells were divided into control group, TM group (treated with 0.4 mg/L TM for 24 h), DDP group (treated with 4 mg/L DDP for 24 h), and DDP+TM group (treated with 0.4 mg/L TM and 4 mg/L DDP for 24 h). CCK-8 assay, plate colony formation assay, scratch assay, and Transwell assay were used to measure the viability and proliferation, migration, and invasion abilities of cells in each group, and Western blotting was used to measure the expression levels of the JAK2-STAT3-HIF1α pathway-related proteins such as JAK-2, p-JAK2, STAT3, p-STAT3, and HIF1α in each group of cells. Results Experimental results showed that compared with the other three groups, the DDP+TM group had significantly lower viability, proliferation and invasion abilities, migration ability at 12 and 24 h, and expression levels of the JAK2-STAT3-HIF1α pathway-related proteins (tLSD=2.14-78.95,P
Document Type: article
File Description: electronic resource
Language: Chinese
ISSN: 2096-529X
Relation: https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1724744959418-2146612763.pdf; https://doaj.org/toc/2096-529X
DOI: 10.13362/j.jpmed.202404001
Access URL: https://doaj.org/article/478cff10a022438fadc80a54acb5bf4a
Accession Number: edsdoj.478cff10a022438fadc80a54acb5bf4a
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  Data: 精准医学杂志, Vol 39, Iss 4, Pp 283-288 (2024)
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  Data: <searchLink fieldCode="DE" term="%22neuroblastoma%22">neuroblastoma</searchLink><br /><searchLink fieldCode="DE" term="%22cisplatin%22">cisplatin</searchLink><br /><searchLink fieldCode="DE" term="%22tunicamycin%22">tunicamycin</searchLink><br /><searchLink fieldCode="DE" term="%22janus+kinase+2%22">janus kinase 2</searchLink><br /><searchLink fieldCode="DE" term="%22stat3+transcription+factor%22">stat3 transcription factor</searchLink><br /><searchLink fieldCode="DE" term="%22hypoxia-inducible+factor+1%2C+alpha+subunit%22">hypoxia-inducible factor 1, alpha subunit</searchLink><br /><searchLink fieldCode="DE" term="%22cell+movement%22">cell movement</searchLink><br /><searchLink fieldCode="DE" term="%22cell+proliferation%22">cell proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
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  Data: Objective To investigate the inhibitory effect of cisplatin (DDP) combined with tunicamycin (TM) on human neuroblastoma SH-SY5Y and SK-N-SH cells and related mechanism. Methods Human neuroblastoma SH-SY5Y and SK-N-SH cells were divided into control group, TM group (treated with 0.4 mg/L TM for 24 h), DDP group (treated with 4 mg/L DDP for 24 h), and DDP+TM group (treated with 0.4 mg/L TM and 4 mg/L DDP for 24 h). CCK-8 assay, plate colony formation assay, scratch assay, and Transwell assay were used to measure the viability and proliferation, migration, and invasion abilities of cells in each group, and Western blotting was used to measure the expression levels of the JAK2-STAT3-HIF1α pathway-related proteins such as JAK-2, p-JAK2, STAT3, p-STAT3, and HIF1α in each group of cells. Results Experimental results showed that compared with the other three groups, the DDP+TM group had significantly lower viability, proliferation and invasion abilities, migration ability at 12 and 24 h, and expression levels of the JAK2-STAT3-HIF1α pathway-related proteins (tLSD=2.14-78.95,P
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        PageCount: 6
        StartPage: 283
    Subjects:
      – SubjectFull: neuroblastoma
        Type: general
      – SubjectFull: cisplatin
        Type: general
      – SubjectFull: tunicamycin
        Type: general
      – SubjectFull: janus kinase 2
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      – SubjectFull: stat3 transcription factor
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