Lack of association of polymorphic variants of genes encoding zinc transporters with the risk of orofacial cleft-affected pregnancies
| Title: | Lack of association of polymorphic variants of genes encoding zinc transporters with the risk of orofacial cleft-affected pregnancies |
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| Authors: | Margarita Lianeri, Kamil K. Hozyasz, Adrianna Mostowska, Barbara Offert, Pawel P. Jagodzinski |
| Source: | Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 618-623 (2010) |
| Publisher Information: | Via Medica, 2010. |
| Publication Year: | 2010 |
| Collection: | LCC:Cytology |
| Subject Terms: | CL/P, Zn, zinc transporters, SLC30A, SLC39A, polymorphism, Cytology, QH573-671 |
| More Details: | Maternal zinc deficiency seems to be a risk factor for orofacial clefts in offspring. This study was undertaken toinvestigate the involvement of polymorphic variants of genes for zinc transporters in the susceptibility of clefting. PCRRFLPanalysis was used to analyze single nucleotide polymorphisms of SLC30A1 (rs7526700, rs2278651, rs611386),SLC30A4 (rs2453531, rs8029246), SLC30A5 (rs351444, rs164393, rs6886492), SLC39A1 (rs10127484, rs11264736), andSLC39A3 (rs759071, rs4806874, rs10415622) in mothers of children with non-syndromic cleft lip with or without cleftpalate (CL/P) and control mothers. The allele, genotype, and haplotype distribution was found to be similar among case andcontrol mothers. Also, the gene-by-gene interaction analysis conducted using the Multifactor Dimensionality Reductionapproach revealed no significant interactive genetic effect on having a child with a cleft. In conclusion, our results demonstratedthat the analyzed polymorphic variants of genes for zinc transporters are not implicated in abnormal palatogenesisin the investigated group of women from the Polish population. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0239-8508 1897-5631 |
| Relation: | http://www.fhc.viamedica.pl/darmowy_pdf.phtml?indeks=128&indeks_art=1285; https://doaj.org/toc/0239-8508; https://doaj.org/toc/1897-5631 |
| Access URL: | https://doaj.org/article/44a7ade45bf7499ea2b210023b5935a0 |
| Accession Number: | edsdoj.44a7ade45bf7499ea2b210023b5935a0 |
| Database: | Directory of Open Access Journals |
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