Academic Journal
View in EDS
PDF Full Text

Antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized controlled trial.

Bibliographic Details
Title: Antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized controlled trial.
Authors: Yoichi Matsui, Sohei Satoi, Masaki Kaibori, Hideyoshi Toyokawa, Hiroaki Yanagimoto, Kosuke Matsui, Morihiko Ishizaki, A-Hon Kwon
Source: PLoS ONE, Vol 9, Iss 9, p e106702 (2014)
Publisher Information: Public Library of Science (PLoS), 2014.
Publication Year: 2014
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Recent meta-analyses concluded that antibiotic prophylaxis is not warranted in low-risk laparoscopic cholecystectomy. However, most trials in the meta-analyses had a relatively small sample size and were statistically underpowered. In addition, many of the trials mentioned potential cost savings owing to the elimination of prophylactic antibiotics. However, no trial has statistically estimated the cost effectiveness. To evaluate the results of meta-analyses, we conducted a randomized controlled trial on the role of prophylactic antibiotics in low-risk laparoscopic cholecystectomy with an adequate sample size.From March 2007 to May 2013, at the Department of Surgery, Kansai Medical University, patients who were scheduled for elective laparoscopic cholecystectomy were randomly assigned to one of two arms: those who were and were not administered prophylactic antibiotics. The primary endpoint was the occurrence of postoperative infections and secondary endpoints were postoperative hospital stay and medical costs.During the study period, 518 patients were assigned to the Antibiotics group and 519 to the No antibiotics group. Occurrences of surgical site infections, distant infections and overall infections were significantly lower in the Antibiotics group than in the No antibiotics group (0.8 vs. 3.7%, p = 0.001, OR: 0.205 (95%CI: 0.069 to 0.606); 0.4 vs. 3.1%, p = 0.0004, OR: 0.122 (95%CI: 0.028 to 0.533); 1.2 vs. 6.7%; p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: http://europepmc.org/articles/PMC4156368?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0106702
Access URL: https://doaj.org/article/426673bfaada4f17b9a55e91c1a582d4
Accession Number: edsdoj.426673bfaada4f17b9a55e91c1a582d4
Database: Directory of Open Access Journals
FullText Links:
  – Type: pdflink
    Url: https://content.ebscohost.com/cds/retrieve?content=AQICAHjPtM4BHU3ZchRwgzYmadcigk49r9CVlbU7V5F6lgH7WwEl8ntUXra4WkyK6BOYvZdKAAAA4TCB3gYJKoZIhvcNAQcGoIHQMIHNAgEAMIHHBgkqhkiG9w0BBwEwHgYJYIZIAWUDBAEuMBEEDBb_XVU6b0ASV_L2cwIBEICBmRcLtfotpEy5I4Kc5ud1mGQL-JwgpHhG05UY8NbmHzmQNhABFzbo34u2tsVtchC-1AGiEHQv883OlbUjWnvl-aEoXIvsdqveeZcDlTbcDyrzVPVvT057PhtsxvdQSY3Ms6yhZA8lrcukfkFiCleoEDLVsRqu_yF5yAhwMOd2i5jZWgxJbm3snsAklfFsANd6iECfQhdHo-YBlA==
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=19326203&ISBN=&volume=9&issue=9&date=20140101&spage=e106702&pages=&title=PLoS ONE&atitle=Antibiotic%20prophylaxis%20in%20laparoscopic%20cholecystectomy%3A%20a%20randomized%20controlled%20trial.&aulast=Yoichi%20Matsui&id=DOI:10.1371/journal.pone.0106702
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/426673bfaada4f17b9a55e91c1a582d4
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.426673bfaada4f17b9a55e91c1a582d4
RelevancyScore: 848
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 848.219055175781
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized controlled trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yoichi+Matsui%22">Yoichi Matsui</searchLink><br /><searchLink fieldCode="AR" term="%22Sohei+Satoi%22">Sohei Satoi</searchLink><br /><searchLink fieldCode="AR" term="%22Masaki+Kaibori%22">Masaki Kaibori</searchLink><br /><searchLink fieldCode="AR" term="%22Hideyoshi+Toyokawa%22">Hideyoshi Toyokawa</searchLink><br /><searchLink fieldCode="AR" term="%22Hiroaki+Yanagimoto%22">Hiroaki Yanagimoto</searchLink><br /><searchLink fieldCode="AR" term="%22Kosuke+Matsui%22">Kosuke Matsui</searchLink><br /><searchLink fieldCode="AR" term="%22Morihiko+Ishizaki%22">Morihiko Ishizaki</searchLink><br /><searchLink fieldCode="AR" term="%22A-Hon+Kwon%22">A-Hon Kwon</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: PLoS ONE, Vol 9, Iss 9, p e106702 (2014)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Public Library of Science (PLoS), 2014.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2014
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine<br />LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Recent meta-analyses concluded that antibiotic prophylaxis is not warranted in low-risk laparoscopic cholecystectomy. However, most trials in the meta-analyses had a relatively small sample size and were statistically underpowered. In addition, many of the trials mentioned potential cost savings owing to the elimination of prophylactic antibiotics. However, no trial has statistically estimated the cost effectiveness. To evaluate the results of meta-analyses, we conducted a randomized controlled trial on the role of prophylactic antibiotics in low-risk laparoscopic cholecystectomy with an adequate sample size.From March 2007 to May 2013, at the Department of Surgery, Kansai Medical University, patients who were scheduled for elective laparoscopic cholecystectomy were randomly assigned to one of two arms: those who were and were not administered prophylactic antibiotics. The primary endpoint was the occurrence of postoperative infections and secondary endpoints were postoperative hospital stay and medical costs.During the study period, 518 patients were assigned to the Antibiotics group and 519 to the No antibiotics group. Occurrences of surgical site infections, distant infections and overall infections were significantly lower in the Antibiotics group than in the No antibiotics group (0.8 vs. 3.7%, p = 0.001, OR: 0.205 (95%CI: 0.069 to 0.606); 0.4 vs. 3.1%, p = 0.0004, OR: 0.122 (95%CI: 0.028 to 0.533); 1.2 vs. 6.7%; p
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1932-6203
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://europepmc.org/articles/PMC4156368?pdf=render; https://doaj.org/toc/1932-6203
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1371/journal.pone.0106702
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/426673bfaada4f17b9a55e91c1a582d4" linkWindow="_blank">https://doaj.org/article/426673bfaada4f17b9a55e91c1a582d4</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.426673bfaada4f17b9a55e91c1a582d4
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.426673bfaada4f17b9a55e91c1a582d4
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1371/journal.pone.0106702
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e106702
    Subjects:
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: Antibiotic prophylaxis in laparoscopic cholecystectomy: a randomized controlled trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yoichi Matsui
      – PersonEntity:
          Name:
            NameFull: Sohei Satoi
      – PersonEntity:
          Name:
            NameFull: Masaki Kaibori
      – PersonEntity:
          Name:
            NameFull: Hideyoshi Toyokawa
      – PersonEntity:
          Name:
            NameFull: Hiroaki Yanagimoto
      – PersonEntity:
          Name:
            NameFull: Kosuke Matsui
      – PersonEntity:
          Name:
            NameFull: Morihiko Ishizaki
      – PersonEntity:
          Name:
            NameFull: A-Hon Kwon
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2014
          Identifiers:
            – Type: issn-print
              Value: 19326203
          Numbering:
            – Type: volume
              Value: 9
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: PLoS ONE
              Type: main
ResultId 1