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Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model

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Title: Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
Authors: Yingjuan Liu, Weihua Jin, Zhenzhen Deng, Jing Wang, Quanbin Zhang
Source: Marine Drugs, Vol 18, Iss 9, p 438 (2020)
Publisher Information: MDPI AG, 2020.
Publication Year: 2020
Collection: LCC:Biology (General)
Subject Terms: glucuronomannan oligosaccharides, behavioral deficits, Parkinson’ disease, apoptosis, Biology (General), QH301-705.5
More Details: Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found that a heteropolysaccharide from Saccharina japonica exhibits neuroprotective effects through antioxidative stress. In view of its high molecular weight and complex structure, we degraded the polysaccharide and subsequently obtained four oligosaccharides. In this study, we aimed to further detect the neuroprotective mechanism of the oligosaccharides. We applied MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to induce PD, and glucuronomannan oligosaccharides (GMn) was subsequently administered. Results showed that GMn ameliorated behavioral deficits in Parkinsonism mice. Furthermore, we observed that glucuronomannan oligosaccharides contributed to down-regulating the apoptotic signaling pathway through enhancing the expression of tyrosine hydroxylase (TH) in dopaminergic neurons. These results suggest that glucuronomannan oligosaccharides protect dopaminergic neurons from apoptosis in PD mice.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1660-3397
Relation: https://www.mdpi.com/1660-3397/18/9/438; https://doaj.org/toc/1660-3397
DOI: 10.3390/md18090438
Access URL: https://doaj.org/article/e40e51691f83414bb0e3aedb2e1a74e3
Accession Number: edsdoj.40e51691f83414bb0e3aedb2e1a74e3
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  Data: Marine Drugs, Vol 18, Iss 9, p 438 (2020)
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  Data: Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found that a heteropolysaccharide from Saccharina japonica exhibits neuroprotective effects through antioxidative stress. In view of its high molecular weight and complex structure, we degraded the polysaccharide and subsequently obtained four oligosaccharides. In this study, we aimed to further detect the neuroprotective mechanism of the oligosaccharides. We applied MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to induce PD, and glucuronomannan oligosaccharides (GMn) was subsequently administered. Results showed that GMn ameliorated behavioral deficits in Parkinsonism mice. Furthermore, we observed that glucuronomannan oligosaccharides contributed to down-regulating the apoptotic signaling pathway through enhancing the expression of tyrosine hydroxylase (TH) in dopaminergic neurons. These results suggest that glucuronomannan oligosaccharides protect dopaminergic neurons from apoptosis in PD mice.
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