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Does prostate-specific antigen (PSA) mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?

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Title: Does prostate-specific antigen (PSA) mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?
Authors: Jin-Woo Jung, Young Dong Yu, Young Ju Lee, Jung Jun Kim, Hak Min Lee, Jong Jin Oh, Sangchul Lee, Sang Wook Lee, Sang Eun Lee, Seong Jin Jeong
Source: Asian Journal of Andrology, Vol 21, Iss 1, Pp 86-91 (2019)
Publisher Information: Wolters Kluwer Medknow Publications, 2019.
Publication Year: 2019
Collection: LCC:Diseases of the genitourinary system. Urology
Subject Terms: benign prostatic hyperplasia, obesity, prostate volume, prostate-specific antigen mass, Diseases of the genitourinary system. Urology, RC870-923
More Details: We evaluated whether the prostate-specific antigen (PSA) mass or free PSA (fPSA) mass (i.e., absolute amount of total circulating PSA or fPSA protein, respectively), versus serum PSA or fPSA concentration, improves the accuracy of predicting the total prostate volume (TPV) in relation to obesity. Among men whose multicore (≥12) transrectal prostate biopsy was negative, 586 who had a PSA of ≤10 ng ml−1 and underwent the fPSA test prior to biopsy were enrolled. The PSA mass or fPSA mass (μ g) was calculated by multiplying the serum level by plasma volume. At each TPV cut-off point (30 ml, 40 ml, and 50 ml), the areas under the receiver operating characteristics curve (AUCs) of each variable were compared in obesity-based subgroups. AUCs of fPSA and fPSA mass for predicting TPV were significantly larger than those for PSA and PSA mass by 8.7%–12.1% at all cut-off points. Subgroup analyses based on obesity showed that, although PSA mass and fPSA mass enhanced accuracy by 4% (P = 0.031) and 1.8% (P = 0.003), respectively, for determining TPVs of ≥30 ml and ≥50 ml in obese and overweight men, they did not improve the accuracy in most other combinations of the degrees of obesity with TPV cut-off points. Thus, compared with serum PSA or fPSA, the absolute amount of PSA or fPSA protein mass improved the accuracy of predicting TPV in obese men very minimally and only for certain TPV cut-off points. Hence, these indicators may not provide clinically meaningful improvement in predicting TPV in obese men.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1008-682X
1745-7262
Relation: http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=1;spage=86;epage=91;aulast=Jung; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262
DOI: 10.4103/aja.aja_66_18
Access URL: https://doaj.org/article/40ace0827a874fc9a37f9965a41ca244
Accession Number: edsdoj.40ace0827a874fc9a37f9965a41ca244
Database: Directory of Open Access Journals
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  Data: Does prostate-specific antigen (PSA) mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?
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  Data: <searchLink fieldCode="AR" term="%22Jin-Woo+Jung%22">Jin-Woo Jung</searchLink><br /><searchLink fieldCode="AR" term="%22Young+Dong+Yu%22">Young Dong Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Young+Ju+Lee%22">Young Ju Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Jung+Jun+Kim%22">Jung Jun Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Hak+Min+Lee%22">Hak Min Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Jong+Jin+Oh%22">Jong Jin Oh</searchLink><br /><searchLink fieldCode="AR" term="%22Sangchul+Lee%22">Sangchul Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Sang+Wook+Lee%22">Sang Wook Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Sang+Eun+Lee%22">Sang Eun Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Seong+Jin+Jeong%22">Seong Jin Jeong</searchLink>
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  Data: Asian Journal of Andrology, Vol 21, Iss 1, Pp 86-91 (2019)
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  Data: <searchLink fieldCode="DE" term="%22benign+prostatic+hyperplasia%22">benign prostatic hyperplasia</searchLink><br /><searchLink fieldCode="DE" term="%22obesity%22">obesity</searchLink><br /><searchLink fieldCode="DE" term="%22prostate+volume%22">prostate volume</searchLink><br /><searchLink fieldCode="DE" term="%22prostate-specific+antigen+mass%22">prostate-specific antigen mass</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+genitourinary+system%2E+Urology%22">Diseases of the genitourinary system. Urology</searchLink><br /><searchLink fieldCode="DE" term="%22RC870-923%22">RC870-923</searchLink>
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  Data: We evaluated whether the prostate-specific antigen (PSA) mass or free PSA (fPSA) mass (i.e., absolute amount of total circulating PSA or fPSA protein, respectively), versus serum PSA or fPSA concentration, improves the accuracy of predicting the total prostate volume (TPV) in relation to obesity. Among men whose multicore (≥12) transrectal prostate biopsy was negative, 586 who had a PSA of ≤10 ng ml−1 and underwent the fPSA test prior to biopsy were enrolled. The PSA mass or fPSA mass (μ g) was calculated by multiplying the serum level by plasma volume. At each TPV cut-off point (30 ml, 40 ml, and 50 ml), the areas under the receiver operating characteristics curve (AUCs) of each variable were compared in obesity-based subgroups. AUCs of fPSA and fPSA mass for predicting TPV were significantly larger than those for PSA and PSA mass by 8.7%–12.1% at all cut-off points. Subgroup analyses based on obesity showed that, although PSA mass and fPSA mass enhanced accuracy by 4% (P = 0.031) and 1.8% (P = 0.003), respectively, for determining TPVs of ≥30 ml and ≥50 ml in obese and overweight men, they did not improve the accuracy in most other combinations of the degrees of obesity with TPV cut-off points. Thus, compared with serum PSA or fPSA, the absolute amount of PSA or fPSA protein mass improved the accuracy of predicting TPV in obese men very minimally and only for certain TPV cut-off points. Hence, these indicators may not provide clinically meaningful improvement in predicting TPV in obese men.
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      – SubjectFull: obesity
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      – SubjectFull: prostate volume
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