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Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway

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Title: Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway
Authors: Tadashi Shiohama, Hideki Uchikawa, Nobuhiro Nitta, Tomozumi Takatani, Shingo Matsuda, Alpen Ortug, Emi Takahashi, Daisuke Sawada, Eiji Shimizu, Katsunori Fujii, Ichio Aoki, Hiromichi Hamada
Source: Frontiers in Neuroscience, Vol 18 (2024)
Publisher Information: Frontiers Media S.A., 2024.
Publication Year: 2024
Collection: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Subject Terms: hedgehog signaling, Ptch, Gorlin syndrome, brain magnetic resonance imaging, laterality, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
More Details: Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in the cerebrum, cerebellum, and cerebral ventricles, suggesting the association between brain morphology and the constitutive hyperactivation of hedgehog signaling, while the changes of regional brain volumes in upregulated hedgehog signaling pathway remains unclear so far. Herein, we investigated comprehensive brain regional volumes using quantitative structural brain MRI, and identified increased volumes of amygdala, striatum, and pallidum on the global segmentation, and increased volumes of the lateral and medial parts of the central nucleus of the amygdala on the detail segmentation in Ptch heterozygous deletion mice. Our data may enhance comprehension of the association between brain morphogenic changes and hyperactivity in hedgehog signaling.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1662-453X
Relation: https://www.frontiersin.org/articles/10.3389/fnins.2024.1449673/full; https://doaj.org/toc/1662-453X
DOI: 10.3389/fnins.2024.1449673
Access URL: https://doaj.org/article/3f6094d326054064a78690b38cd63dd2
Accession Number: edsdoj.3f6094d326054064a78690b38cd63dd2
Database: Directory of Open Access Journals
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  Data: Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway
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  Data: <searchLink fieldCode="AR" term="%22Tadashi+Shiohama%22">Tadashi Shiohama</searchLink><br /><searchLink fieldCode="AR" term="%22Hideki+Uchikawa%22">Hideki Uchikawa</searchLink><br /><searchLink fieldCode="AR" term="%22Nobuhiro+Nitta%22">Nobuhiro Nitta</searchLink><br /><searchLink fieldCode="AR" term="%22Tomozumi+Takatani%22">Tomozumi Takatani</searchLink><br /><searchLink fieldCode="AR" term="%22Shingo+Matsuda%22">Shingo Matsuda</searchLink><br /><searchLink fieldCode="AR" term="%22Alpen+Ortug%22">Alpen Ortug</searchLink><br /><searchLink fieldCode="AR" term="%22Emi+Takahashi%22">Emi Takahashi</searchLink><br /><searchLink fieldCode="AR" term="%22Daisuke+Sawada%22">Daisuke Sawada</searchLink><br /><searchLink fieldCode="AR" term="%22Eiji+Shimizu%22">Eiji Shimizu</searchLink><br /><searchLink fieldCode="AR" term="%22Katsunori+Fujii%22">Katsunori Fujii</searchLink><br /><searchLink fieldCode="AR" term="%22Ichio+Aoki%22">Ichio Aoki</searchLink><br /><searchLink fieldCode="AR" term="%22Hiromichi+Hamada%22">Hiromichi Hamada</searchLink>
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  Data: Frontiers in Neuroscience, Vol 18 (2024)
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  Data: <searchLink fieldCode="DE" term="%22hedgehog+signaling%22">hedgehog signaling</searchLink><br /><searchLink fieldCode="DE" term="%22Ptch%22">Ptch</searchLink><br /><searchLink fieldCode="DE" term="%22Gorlin+syndrome%22">Gorlin syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22brain+magnetic+resonance+imaging%22">brain magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22laterality%22">laterality</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%2E+Biological+psychiatry%2E+Neuropsychiatry%22">Neurosciences. Biological psychiatry. Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22RC321-571%22">RC321-571</searchLink>
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  Data: Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in the cerebrum, cerebellum, and cerebral ventricles, suggesting the association between brain morphology and the constitutive hyperactivation of hedgehog signaling, while the changes of regional brain volumes in upregulated hedgehog signaling pathway remains unclear so far. Herein, we investigated comprehensive brain regional volumes using quantitative structural brain MRI, and identified increased volumes of amygdala, striatum, and pallidum on the global segmentation, and increased volumes of the lateral and medial parts of the central nucleus of the amygdala on the detail segmentation in Ptch heterozygous deletion mice. Our data may enhance comprehension of the association between brain morphogenic changes and hyperactivity in hedgehog signaling.
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      – SubjectFull: hedgehog signaling
        Type: general
      – SubjectFull: Ptch
        Type: general
      – SubjectFull: Gorlin syndrome
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