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Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene

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Title: Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene
Authors: Tatiana Rozental, Luis Filipe Mascarenhas, Ronaldo Rozenbaum, Raphael Gomes, Grasiely Souza Mattos, Cecília Carlos Magno, Daniele Nunes Almeida, Maria Inês Doria Rossi, Alexsandra RM Favacho, Elba Regina Sampaio de Lemos
Source: Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 5, Pp 695-697 (2012)
Publisher Information: Fundação Oswaldo Cruz (FIOCRUZ), 2012.
Publication Year: 2012
Collection: LCC:Microbiology
LCC:Infectious and parasitic diseases
Subject Terms: Q fever, bronchoalveolar lavage, molecular analysis, seronegative polyarthritis, methotrexate, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
More Details: Coxiella burnetii is the agent of Q fever , an emergent worldwide zoonosis of wide clinical spectrum. Although C. burnetii infection is typically associated with acute infection, atypical pneumonia and flu-like symptoms, endocarditis, osteoarticular manifestations and severe disease are possible, especially when the patient has a suppressed immune system; however, these severe complications are typically neglected. This study reports the sequencing of the repetitive element IS1111 of the transposase gene of C. burnetii from blood and bronchoalveolar lavage (BAL) samples from a patient with severe pneumonia following methotrexate therapy, resulting in the molecular diagnosis of Q fever in a patient who had been diagnosed with active seronegative polyarthritis two years earlier. To the best of our knowledge, this represents the first documented case of the isolation of C. burnetii DNA from a BAL sample.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1678-8060
0074-0276
Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000500021&lng=en&tlng=en; https://doaj.org/toc/1678-8060
DOI: 10.1590/S0074-02762012000500021
Access URL: https://doaj.org/article/392af2e1136a4f968d269714c112f310
Accession Number: edsdoj.392af2e1136a4f968d269714c112f310
Database: Directory of Open Access Journals
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  Data: Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene
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  Data: <searchLink fieldCode="AR" term="%22Tatiana+Rozental%22">Tatiana Rozental</searchLink><br /><searchLink fieldCode="AR" term="%22Luis+Filipe+Mascarenhas%22">Luis Filipe Mascarenhas</searchLink><br /><searchLink fieldCode="AR" term="%22Ronaldo+Rozenbaum%22">Ronaldo Rozenbaum</searchLink><br /><searchLink fieldCode="AR" term="%22Raphael+Gomes%22">Raphael Gomes</searchLink><br /><searchLink fieldCode="AR" term="%22Grasiely+Souza+Mattos%22">Grasiely Souza Mattos</searchLink><br /><searchLink fieldCode="AR" term="%22Cecília+Carlos+Magno%22">Cecília Carlos Magno</searchLink><br /><searchLink fieldCode="AR" term="%22Daniele+Nunes+Almeida%22">Daniele Nunes Almeida</searchLink><br /><searchLink fieldCode="AR" term="%22Maria+Inês+Doria+Rossi%22">Maria Inês Doria Rossi</searchLink><br /><searchLink fieldCode="AR" term="%22Alexsandra+RM+Favacho%22">Alexsandra RM Favacho</searchLink><br /><searchLink fieldCode="AR" term="%22Elba+Regina+Sampaio+de+Lemos%22">Elba Regina Sampaio de Lemos</searchLink>
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  Data: Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 5, Pp 695-697 (2012)
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  Data: Fundação Oswaldo Cruz (FIOCRUZ), 2012.
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  Data: 2012
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  Data: LCC:Microbiology<br />LCC:Infectious and parasitic diseases
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Q+fever%22">Q fever</searchLink><br /><searchLink fieldCode="DE" term="%22bronchoalveolar+lavage%22">bronchoalveolar lavage</searchLink><br /><searchLink fieldCode="DE" term="%22molecular+analysis%22">molecular analysis</searchLink><br /><searchLink fieldCode="DE" term="%22seronegative+polyarthritis%22">seronegative polyarthritis</searchLink><br /><searchLink fieldCode="DE" term="%22methotrexate%22">methotrexate</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiology%22">Microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22QR1-502%22">QR1-502</searchLink><br /><searchLink fieldCode="DE" term="%22Infectious+and+parasitic+diseases%22">Infectious and parasitic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22RC109-216%22">RC109-216</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Coxiella burnetii is the agent of Q fever , an emergent worldwide zoonosis of wide clinical spectrum. Although C. burnetii infection is typically associated with acute infection, atypical pneumonia and flu-like symptoms, endocarditis, osteoarticular manifestations and severe disease are possible, especially when the patient has a suppressed immune system; however, these severe complications are typically neglected. This study reports the sequencing of the repetitive element IS1111 of the transposase gene of C. burnetii from blood and bronchoalveolar lavage (BAL) samples from a patient with severe pneumonia following methotrexate therapy, resulting in the molecular diagnosis of Q fever in a patient who had been diagnosed with active seronegative polyarthritis two years earlier. To the best of our knowledge, this represents the first documented case of the isolation of C. burnetii DNA from a BAL sample.
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  Data: 1678-8060<br />0074-0276
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  Data: 10.1590/S0074-02762012000500021
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        Value: 10.1590/S0074-02762012000500021
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      – Text: English
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        PageCount: 3
        StartPage: 695
    Subjects:
      – SubjectFull: Q fever
        Type: general
      – SubjectFull: bronchoalveolar lavage
        Type: general
      – SubjectFull: molecular analysis
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      – SubjectFull: seronegative polyarthritis
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      – SubjectFull: methotrexate
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      – SubjectFull: QR1-502
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      – SubjectFull: Infectious and parasitic diseases
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      – TitleFull: Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene
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