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pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

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Title: pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation
Authors: Olga Boix, Marion Martinez, Santiago Vidal, Marta Giménez-Alejandre, Lluís Palenzuela, Laura Lorenzo-Sanz, Laura Quevedo, Olivier Moscoso, Jorge Ruiz-Orera, Pilar Ximénez-Embún, Nikaoly Ciriaco, Paolo Nuciforo, Camille Stephan-Otto Attolini, M. Mar Albà, Javier Muñoz, Tian V. Tian, Ignacio Varela, Ana Vivancos, Santiago Ramón y Cajal, Purificación Muñoz, Carmen Rivas, María Abad
Source: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
More Details: Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-34529-6
Access URL: https://doaj.org/article/33af4f773e164ef482636020595123dd
Accession Number: edsdoj.33af4f773e164ef482636020595123dd
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Olga+Boix%22">Olga Boix</searchLink><br /><searchLink fieldCode="AR" term="%22Marion+Martinez%22">Marion Martinez</searchLink><br /><searchLink fieldCode="AR" term="%22Santiago+Vidal%22">Santiago Vidal</searchLink><br /><searchLink fieldCode="AR" term="%22Marta+Giménez-Alejandre%22">Marta Giménez-Alejandre</searchLink><br /><searchLink fieldCode="AR" term="%22Lluís+Palenzuela%22">Lluís Palenzuela</searchLink><br /><searchLink fieldCode="AR" term="%22Laura+Lorenzo-Sanz%22">Laura Lorenzo-Sanz</searchLink><br /><searchLink fieldCode="AR" term="%22Laura+Quevedo%22">Laura Quevedo</searchLink><br /><searchLink fieldCode="AR" term="%22Olivier+Moscoso%22">Olivier Moscoso</searchLink><br /><searchLink fieldCode="AR" term="%22Jorge+Ruiz-Orera%22">Jorge Ruiz-Orera</searchLink><br /><searchLink fieldCode="AR" term="%22Pilar+Ximénez-Embún%22">Pilar Ximénez-Embún</searchLink><br /><searchLink fieldCode="AR" term="%22Nikaoly+Ciriaco%22">Nikaoly Ciriaco</searchLink><br /><searchLink fieldCode="AR" term="%22Paolo+Nuciforo%22">Paolo Nuciforo</searchLink><br /><searchLink fieldCode="AR" term="%22Camille+Stephan-Otto+Attolini%22">Camille Stephan-Otto Attolini</searchLink><br /><searchLink fieldCode="AR" term="%22M%2E+Mar+Albà%22">M. Mar Albà</searchLink><br /><searchLink fieldCode="AR" term="%22Javier+Muñoz%22">Javier Muñoz</searchLink><br /><searchLink fieldCode="AR" term="%22Tian+V%2E+Tian%22">Tian V. Tian</searchLink><br /><searchLink fieldCode="AR" term="%22Ignacio+Varela%22">Ignacio Varela</searchLink><br /><searchLink fieldCode="AR" term="%22Ana+Vivancos%22">Ana Vivancos</searchLink><br /><searchLink fieldCode="AR" term="%22Santiago+Ramón+y+Cajal%22">Santiago Ramón y Cajal</searchLink><br /><searchLink fieldCode="AR" term="%22Purificación+Muñoz%22">Purificación Muñoz</searchLink><br /><searchLink fieldCode="AR" term="%22Carmen+Rivas%22">Carmen Rivas</searchLink><br /><searchLink fieldCode="AR" term="%22María+Abad%22">María Abad</searchLink>
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  Data: Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.
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