Bibliographic Details
| Title: |
Simultaneous determination of small molecules and proteins in wastewater-based epidemiology |
| Authors: |
Yolanda Picó, Antoni Ginebreda, Montserrat Carrascal, Joaquin Abian, Damià Barceló |
| Source: |
Frontiers in Analytical Science, Vol 4 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Analytical chemistry |
| Subject Terms: |
biomarkers, proteomics, wastewater, high-resolution mass spectrometry (HRMS), metabolites, Analytical chemistry, QD71-142 |
| More Details: |
Wastewater-based epidemiology (WBE) aims to understand a population’s consumption habits, exposure to chemicals, and the prevalence of specific diseases or pathogens. This is achieved by the chemical or biological/genomic determination of biomarkers (e.g., excreted metabolic products), which are in urban wastewater generated by that population. WBE has been mostly linked to the determination of small molecules of human origin using liquid-chromatography mass spectrometry (LC-MS). In this Perspective, we provide a state-of-the-art and critical evaluation of further developments in the information achieved by determining small molecules as well as the most promising analytical techniques to enlarge the information obtained. By simultaneously monitoring small and large molecules we can comprehensively trace the population’s health by their consumption of prescribed pharmaceuticals and illegal drugs, as well as by the amount of excreted macromolecule biomarkers such as peptides and proteins. Moreover, species-specific protein sequences allow us to monitor animal populations reflecting farming and slaughterhouse activities (poultry, pigs…) or pest occurrences (rats). To this end, the capability of proteomic studies using high-resolution tandem mass spectrometry is highlighted and compared in the context of other advances in the broader field of high-resolution mass spectrometry (HRMS). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-9283 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/frans.2024.1367448/full; https://doaj.org/toc/2673-9283 |
| DOI: |
10.3389/frans.2024.1367448 |
| Access URL: |
https://doaj.org/article/338c4676e44240cc968bb34fb4af4713 |
| Accession Number: |
edsdoj.338c4676e44240cc968bb34fb4af4713 |
| Database: |
Directory of Open Access Journals |
