Academic Journal
View in EDS
Linked Full Text

Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma

Bibliographic Details
Title: Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma
Authors: Ruiqi Zheng, Shuang Weng, Jianping Xu, Zhuo Li, Yaru Wang, Zulihumaer Aizimuaji, Sheng Ma, Linlin Zheng, Haiyang Li, Wantao Ying, Weiqi Rong, Ting Xiao
Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3564-3574 (2023)
Publisher Information: Elsevier, 2023.
Publication Year: 2023
Collection: LCC:Biotechnology
Subject Terms: Sorafenib resistance, Autophagy, Biotransformation, Proteomics, HCC, PI3K/AKT/mTOR, Biotechnology, TP248.13-248.65
More Details: As sorafenib is a first-line drug for treating advanced hepatocellular carcinoma, sorafenib resistance has historically attracted attention. However, most of this attention has been focused on a series of mechanisms related to drug resistance arising after sorafenib treatment. In this study, we used proteomic techniques to explore the potential mechanisms by which pretreatment factors affect sorafenib resistance. The degree of redundant pathway PI3K/AKT activation, biotransformation capacity, and autophagy level in hepatocellular carcinoma patients prior to sorafenib treatment might affect their sensitivity to sorafenib, in which ADH1A and STING1 are key molecules. These three factors could interact mechanistically to promote tumor cell survival, might be malignant features of tumor cells, and are associated with hepatocellular carcinoma prognosis. Our study suggests possible avenues of therapeutic intervention for patients with sorafenib-resistance and the potential application of immunotherapy with the aim of improving the survival of such patients.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2001-0370
Relation: http://www.sciencedirect.com/science/article/pii/S2001037023002398; https://doaj.org/toc/2001-0370
DOI: 10.1016/j.csbj.2023.07.005
Access URL: https://doaj.org/article/3329a2098f694384bab273a36625cbbb
Accession Number: edsdoj.3329a2098f694384bab273a36625cbbb
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=426DA00448234ECF0D77&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.csbj.2023.07.005?
    Name: ScienceDirect (all content)-s8985755
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20010370&ISBN=&volume=21&issue=3564-3574&date=20230101&spage=3564&pages=3564-3574&title=Computational and Structural Biotechnology Journal&atitle=Autophagy%20and%20biotransformation%20affect%20sorafenib%20resistance%20in%20hepatocellular%20carcinoma&aulast=Ruiqi%20Zheng&id=DOI:10.1016/j.csbj.2023.07.005
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/3329a2098f694384bab273a36625cbbb
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.3329a2098f694384bab273a36625cbbb
RelevancyScore: 980
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 979.677185058594
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ruiqi+Zheng%22">Ruiqi Zheng</searchLink><br /><searchLink fieldCode="AR" term="%22Shuang+Weng%22">Shuang Weng</searchLink><br /><searchLink fieldCode="AR" term="%22Jianping+Xu%22">Jianping Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Zhuo+Li%22">Zhuo Li</searchLink><br /><searchLink fieldCode="AR" term="%22Yaru+Wang%22">Yaru Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Zulihumaer+Aizimuaji%22">Zulihumaer Aizimuaji</searchLink><br /><searchLink fieldCode="AR" term="%22Sheng+Ma%22">Sheng Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Linlin+Zheng%22">Linlin Zheng</searchLink><br /><searchLink fieldCode="AR" term="%22Haiyang+Li%22">Haiyang Li</searchLink><br /><searchLink fieldCode="AR" term="%22Wantao+Ying%22">Wantao Ying</searchLink><br /><searchLink fieldCode="AR" term="%22Weiqi+Rong%22">Weiqi Rong</searchLink><br /><searchLink fieldCode="AR" term="%22Ting+Xiao%22">Ting Xiao</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3564-3574 (2023)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Elsevier, 2023.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Biotechnology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Sorafenib+resistance%22">Sorafenib resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Autophagy%22">Autophagy</searchLink><br /><searchLink fieldCode="DE" term="%22Biotransformation%22">Biotransformation</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22HCC%22">HCC</searchLink><br /><searchLink fieldCode="DE" term="%22PI3K%2FAKT%2FmTOR%22">PI3K/AKT/mTOR</searchLink><br /><searchLink fieldCode="DE" term="%22Biotechnology%22">Biotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22TP248%2E13-248%2E65%22">TP248.13-248.65</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: As sorafenib is a first-line drug for treating advanced hepatocellular carcinoma, sorafenib resistance has historically attracted attention. However, most of this attention has been focused on a series of mechanisms related to drug resistance arising after sorafenib treatment. In this study, we used proteomic techniques to explore the potential mechanisms by which pretreatment factors affect sorafenib resistance. The degree of redundant pathway PI3K/AKT activation, biotransformation capacity, and autophagy level in hepatocellular carcinoma patients prior to sorafenib treatment might affect their sensitivity to sorafenib, in which ADH1A and STING1 are key molecules. These three factors could interact mechanistically to promote tumor cell survival, might be malignant features of tumor cells, and are associated with hepatocellular carcinoma prognosis. Our study suggests possible avenues of therapeutic intervention for patients with sorafenib-resistance and the potential application of immunotherapy with the aim of improving the survival of such patients.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2001-0370
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://www.sciencedirect.com/science/article/pii/S2001037023002398; https://doaj.org/toc/2001-0370
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.csbj.2023.07.005
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/3329a2098f694384bab273a36625cbbb" linkWindow="_blank">https://doaj.org/article/3329a2098f694384bab273a36625cbbb</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.3329a2098f694384bab273a36625cbbb
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.3329a2098f694384bab273a36625cbbb
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.csbj.2023.07.005
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 3564
    Subjects:
      – SubjectFull: Sorafenib resistance
        Type: general
      – SubjectFull: Autophagy
        Type: general
      – SubjectFull: Biotransformation
        Type: general
      – SubjectFull: Proteomics
        Type: general
      – SubjectFull: HCC
        Type: general
      – SubjectFull: PI3K/AKT/mTOR
        Type: general
      – SubjectFull: Biotechnology
        Type: general
      – SubjectFull: TP248.13-248.65
        Type: general
    Titles:
      – TitleFull: Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ruiqi Zheng
      – PersonEntity:
          Name:
            NameFull: Shuang Weng
      – PersonEntity:
          Name:
            NameFull: Jianping Xu
      – PersonEntity:
          Name:
            NameFull: Zhuo Li
      – PersonEntity:
          Name:
            NameFull: Yaru Wang
      – PersonEntity:
          Name:
            NameFull: Zulihumaer Aizimuaji
      – PersonEntity:
          Name:
            NameFull: Sheng Ma
      – PersonEntity:
          Name:
            NameFull: Linlin Zheng
      – PersonEntity:
          Name:
            NameFull: Haiyang Li
      – PersonEntity:
          Name:
            NameFull: Wantao Ying
      – PersonEntity:
          Name:
            NameFull: Weiqi Rong
      – PersonEntity:
          Name:
            NameFull: Ting Xiao
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 20010370
          Numbering:
            – Type: volume
              Value: 21
            – Type: issue
              Value: 3564-3574
          Titles:
            – TitleFull: Computational and Structural Biotechnology Journal
              Type: main
ResultId 1