Academic Journal
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)
| Title: | HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA) |
|---|---|
| Authors: | Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie Dong, Pragya Khadka, Szu Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin Kovacs, Erika Benko, Mario A. Ostrowski, Perla M. Del Rio Estrada, Avery Wimpelberg, Christopher Cannon, W. David Hardy, Lynsay MacLaren, Harris Goldstein, Chanson J. Brumme, Guinevere Q. Lee, Rebecca M. Lynch, Zabrina L. Brumme, R. Brad Jones |
| Source: | Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| More Details: | The intact proviral DNA assay quantifies the genomically intact HIV reservoir, but assay failure due to HIV-1 polymorphism has been observed. Here, the authors report a 28% failure rate in a cohort of people with HIV-1, and note within-host HIV-1 diversity as a further challenge to IPDA accuracy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-020-20442-3 |
| Access URL: | https://doaj.org/article/2f1b4a3b13f745078fbaecf15223c1ef |
| Accession Number: | edsdoj.2f1b4a3b13f745078fbaecf15223c1ef |
| Database: | Directory of Open Access Journals |
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