Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression.
| Title: | Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression. |
|---|---|
| Authors: | Yanina Ghiglione, Juliana Falivene, María Julia Ruiz, Natalia Laufer, María Eugenia Socías, Pedro Cahn, Luis Giavedoni, Omar Sued, María Magdalena Gherardi, Horacio Salomón, Gabriela Turk |
| Source: | PLoS ONE, Vol 9, Iss 8, p e104235 (2014) |
| Publisher Information: | Public Library of Science (PLoS), 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further unraveling the link between CD8+ T-cell differentiation and viral control is needed. Here, an immunophenotypic analysis (in terms of memory markers and Programmed cell death 1 (PD-1) expression) of the CD8+ T-cell subset found in primary HIV infection (PHI) was performed. The aim was to seek for associations with functional properties of the CD8+ T-cell subsets, viral control and subsequent disease progression. Also, results were compared with samples from Chronics and Elite Controllers. It was found that normal maturation of total and HIV-specific CD8+ T-cells into memory subsets is skewed in PHI, but not at the dramatic level observed in Chronics. Within the HIV-specific compartment, this alteration was evidenced by an accumulation of effector memory CD8+ T (TEM) cells over fully differentiated terminal effector CD8+ T (TTE) cells. Furthermore, higher proportions of total and HIV-specific CD8+ TEM cells and higher HIV-specific TEM/(TEM+TTE) ratio correlated with markers of faster progression. Analysis of PD-1 expression on total and HIV-specific CD8+ T-cells from PHI subjects revealed not only an association with disease progression but also with skewed memory CD8+ T-cell differentiation. Most notably, significant direct correlations were obtained between the functional capacity of CD8+ T-cells to inhibit viral replication in vitro with higher proportions of fully-differentiated HIV-specific CD8+ TTE cells, both at baseline and at 12 months post-infection. Thus, a relationship between preservation of CD8+ T-cell differentiation pathway and cell functionality was established. This report presents evidence concerning the link among CD8+ T-cell function, phenotype and virus control, hence supporting the instauration of early interventions to prevent irreversible immune damage. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4122399?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0104235 |
| Access URL: | https://doaj.org/article/2e0c64de7fa74c72bbdaccfc087b832b |
| Accession Number: | edsdoj.2e0c64de7fa74c72bbdaccfc087b832b |
| Database: | Directory of Open Access Journals |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0104235 Languages: – Text: English PhysicalDescription: Pagination: StartPage: e104235 Subjects: – SubjectFull: Medicine Type: general – SubjectFull: Science Type: general Titles: – TitleFull: Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yanina Ghiglione – PersonEntity: Name: NameFull: Juliana Falivene – PersonEntity: Name: NameFull: María Julia Ruiz – PersonEntity: Name: NameFull: Natalia Laufer – PersonEntity: Name: NameFull: María Eugenia Socías – PersonEntity: Name: NameFull: Pedro Cahn – PersonEntity: Name: NameFull: Luis Giavedoni – PersonEntity: Name: NameFull: Omar Sued – PersonEntity: Name: NameFull: María Magdalena Gherardi – PersonEntity: Name: NameFull: Horacio Salomón – PersonEntity: Name: NameFull: Gabriela Turk IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2014 Identifiers: – Type: issn-print Value: 19326203 Numbering: – Type: volume Value: 9 – Type: issue Value: 8 Titles: – TitleFull: PLoS ONE Type: main |
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