Academic Journal
View in EDS
Linked Full Text

When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging

Bibliographic Details
Title: When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging
Authors: Robin Pedersen, Linda Geerligs, Micael Andersson, Tetiana Gorbach, Bárbara Avelar-Pereira, Anders Wåhlin, Anna Rieckmann, Lars Nyberg, Alireza Salami
Source: NeuroImage, Vol 242, Iss , Pp 118449- (2021)
Publisher Information: Elsevier, 2021.
Publication Year: 2021
Collection: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Subject Terms: Resting-state fMRI, Functional segregation, Longitudinal study, Graph theory, Cognitive aging, White matter integrity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
More Details: Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes in brain structure and functional architecture. Age-accompanied alterations in brain function have been characterized on a network level as weaker functional connections within brain networks along with stronger interactions between networks. This phenomenon has been described as age-related differences in functional network segregation. It has been suggested that functional networks related to associative processes are particularly sensitive to age-related deterioration in segregation, possibly related to cognitive decline in aging. However, there have been only a few longitudinal studies with inconclusive results. Here, we used a large longitudinal sample of 284 participants between 25 to 80 years of age at baseline, with cognitive and neuroimaging data collected at up to three time points over a 10-year period. We investigated age-related changes in functional segregation among two large-scale systems comprising associative and sensorimotor-related resting-state networks. We found that functional segregation of associative systems declines in aging with exacerbated deterioration from the late fifties. Changes in associative segregation were positively associated with changes in global cognitive ability, suggesting that decreased segregation has negative consequences for domain-general cognitive functions. Age-related changes in system segregation were partly accounted for by changes in white matter integrity, but white matter integrity only weakly influenced the association between segregation and cognition. Together, these novel findings suggest a cascade where reduced white-matter integrity leads to less distinctive functional systems which in turn contributes to cognitive decline in aging.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1095-9572
Relation: http://www.sciencedirect.com/science/article/pii/S1053811921007230; https://doaj.org/toc/1095-9572
DOI: 10.1016/j.neuroimage.2021.118449
Access URL: https://doaj.org/article/2bed8de990c146398a2ebce51ed1d2dd
Accession Number: edsdoj.2bed8de990c146398a2ebce51ed1d2dd
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=48A895B9D7C038A205B4&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.neuroimage.2021.118449?
    Name: ScienceDirect (all content)-s8985755
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=10959572&ISBN=&volume=242&issue=118449-&date=20211101&spage=&pages=&title=NeuroImage&atitle=When%20functional%20blurring%20becomes%20deleterious%3A%20Reduced%20system%20segregation%20is%20associated%20with%20less%20white%20matter%20integrity%20and%20cognitive%20decline%20in%20aging&aulast=Robin%20Pedersen&id=DOI:10.1016/j.neuroimage.2021.118449
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/2bed8de990c146398a2ebce51ed1d2dd
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.2bed8de990c146398a2ebce51ed1d2dd
RelevancyScore: 927
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 926.953369140625
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Robin+Pedersen%22">Robin Pedersen</searchLink><br /><searchLink fieldCode="AR" term="%22Linda+Geerligs%22">Linda Geerligs</searchLink><br /><searchLink fieldCode="AR" term="%22Micael+Andersson%22">Micael Andersson</searchLink><br /><searchLink fieldCode="AR" term="%22Tetiana+Gorbach%22">Tetiana Gorbach</searchLink><br /><searchLink fieldCode="AR" term="%22Bárbara+Avelar-Pereira%22">Bárbara Avelar-Pereira</searchLink><br /><searchLink fieldCode="AR" term="%22Anders+Wåhlin%22">Anders Wåhlin</searchLink><br /><searchLink fieldCode="AR" term="%22Anna+Rieckmann%22">Anna Rieckmann</searchLink><br /><searchLink fieldCode="AR" term="%22Lars+Nyberg%22">Lars Nyberg</searchLink><br /><searchLink fieldCode="AR" term="%22Alireza+Salami%22">Alireza Salami</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: NeuroImage, Vol 242, Iss , Pp 118449- (2021)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Elsevier, 2021.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2021
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Resting-state+fMRI%22">Resting-state fMRI</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+segregation%22">Functional segregation</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+study%22">Longitudinal study</searchLink><br /><searchLink fieldCode="DE" term="%22Graph+theory%22">Graph theory</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+aging%22">Cognitive aging</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+integrity%22">White matter integrity</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%2E+Biological+psychiatry%2E+Neuropsychiatry%22">Neurosciences. Biological psychiatry. Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22RC321-571%22">RC321-571</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes in brain structure and functional architecture. Age-accompanied alterations in brain function have been characterized on a network level as weaker functional connections within brain networks along with stronger interactions between networks. This phenomenon has been described as age-related differences in functional network segregation. It has been suggested that functional networks related to associative processes are particularly sensitive to age-related deterioration in segregation, possibly related to cognitive decline in aging. However, there have been only a few longitudinal studies with inconclusive results. Here, we used a large longitudinal sample of 284 participants between 25 to 80 years of age at baseline, with cognitive and neuroimaging data collected at up to three time points over a 10-year period. We investigated age-related changes in functional segregation among two large-scale systems comprising associative and sensorimotor-related resting-state networks. We found that functional segregation of associative systems declines in aging with exacerbated deterioration from the late fifties. Changes in associative segregation were positively associated with changes in global cognitive ability, suggesting that decreased segregation has negative consequences for domain-general cognitive functions. Age-related changes in system segregation were partly accounted for by changes in white matter integrity, but white matter integrity only weakly influenced the association between segregation and cognition. Together, these novel findings suggest a cascade where reduced white-matter integrity leads to less distinctive functional systems which in turn contributes to cognitive decline in aging.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1095-9572
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://www.sciencedirect.com/science/article/pii/S1053811921007230; https://doaj.org/toc/1095-9572
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.neuroimage.2021.118449
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/2bed8de990c146398a2ebce51ed1d2dd" linkWindow="_blank">https://doaj.org/article/2bed8de990c146398a2ebce51ed1d2dd</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.2bed8de990c146398a2ebce51ed1d2dd
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.2bed8de990c146398a2ebce51ed1d2dd
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.neuroimage.2021.118449
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Resting-state fMRI
        Type: general
      – SubjectFull: Functional segregation
        Type: general
      – SubjectFull: Longitudinal study
        Type: general
      – SubjectFull: Graph theory
        Type: general
      – SubjectFull: Cognitive aging
        Type: general
      – SubjectFull: White matter integrity
        Type: general
      – SubjectFull: Neurosciences. Biological psychiatry. Neuropsychiatry
        Type: general
      – SubjectFull: RC321-571
        Type: general
    Titles:
      – TitleFull: When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Robin Pedersen
      – PersonEntity:
          Name:
            NameFull: Linda Geerligs
      – PersonEntity:
          Name:
            NameFull: Micael Andersson
      – PersonEntity:
          Name:
            NameFull: Tetiana Gorbach
      – PersonEntity:
          Name:
            NameFull: Bárbara Avelar-Pereira
      – PersonEntity:
          Name:
            NameFull: Anders Wåhlin
      – PersonEntity:
          Name:
            NameFull: Anna Rieckmann
      – PersonEntity:
          Name:
            NameFull: Lars Nyberg
      – PersonEntity:
          Name:
            NameFull: Alireza Salami
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 10959572
          Numbering:
            – Type: volume
              Value: 242
            – Type: issue
              Value: 118449-
          Titles:
            – TitleFull: NeuroImage
              Type: main
ResultId 1