Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
| Title: | Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum |
|---|---|
| Authors: | Hui-Chun Wang, Tzu-Yi Ke, Ya-Chen Ko, Jue-Jun Lin, Jui-Sheng Chang, Yuan-Bin Cheng |
| Source: | Marine Drugs, Vol 19, Iss 10, p 529 (2021) |
| Publisher Information: | MDPI AG, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | Penicillium sclerotiorum, azaphilone, anti-inflammatory, Biology (General), QH301-705.5 |
| More Details: | To discover the new medical entity from edible marine algae, our continuously natural product investigation focused on endophytes from marine macroalgae Grateloupia sp. Two new azaphilones, 8a-epi-hypocrellone A (1), 8a-epi-eupenicilazaphilone C (2), together with five known azaphilones, hypocrellone A (3), eupenicilazaphilone C (4), ((1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-2,4-dihydroxy-3-methylbenzaldehyde (5), sclerotiorin (6), and isochromophilone IV (7) were isolated from the alga-derived fungus Penicillium sclerotiorum. The structures of isolated azaphilones (1–7) were elucidated by spectrometric identification, especially HRESIMS, CD, and NMR data analyses. Concerning bioactivity, cytotoxic, anti-inflammatory, and anti-fibrosis activities of those isolates were evaluated. As a result, compound 1 showed selective toxicity toward neuroblastoma cell line SH-SY5Y among seven cancer and one fibroblast cell lines. 20 μM of compounds 1, 3, and 7 inhibited the TNF-α-induced NFκB phosphorylation but did not change the NFκB activity. Compounds 2 and 6 respectively promoted and inhibited SMAD-mediated transcriptional activities stimulated by TGF-β. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1660-3397 |
| Relation: | https://www.mdpi.com/1660-3397/19/10/529; https://doaj.org/toc/1660-3397 |
| DOI: | 10.3390/md19100529 |
| Access URL: | https://doaj.org/article/28a55ddd1b6c489983a2485a8d06932e |
| Accession Number: | edsdoj.28a55ddd1b6c489983a2485a8d06932e |
| Database: | Directory of Open Access Journals |
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