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Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study

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Title: Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
Authors: Nicola Veronese, Sinisa Stefanac, Ai Koyanagi, Nasser M. Al-Daghri, Shaun Sabico, Cyrus Cooper, Renè Rizzoli, Jean-Yves Reginster, Mario Barbagallo, Ligia J. Dominguez, Lee Smith, Stefania Maggi
Source: Frontiers in Endocrinology, Vol 12 (2021)
Publisher Information: Frontiers Media S.A., 2021.
Publication Year: 2021
Collection: LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms: sarcopenia, osteoarthritis of the knee, older people, epidemiology, muscle mass and function, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
More Details: Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-2392
Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.804560/full; https://doaj.org/toc/1664-2392
DOI: 10.3389/fendo.2021.804560
Access URL: https://doaj.org/article/ce276b304ca04c078e15114b8454e36a
Accession Number: edsdoj.276b304ca04c078e15114b8454e36a
Database: Directory of Open Access Journals
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  Data: Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
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  Data: <searchLink fieldCode="AR" term="%22Nicola+Veronese%22">Nicola Veronese</searchLink><br /><searchLink fieldCode="AR" term="%22Sinisa+Stefanac%22">Sinisa Stefanac</searchLink><br /><searchLink fieldCode="AR" term="%22Ai+Koyanagi%22">Ai Koyanagi</searchLink><br /><searchLink fieldCode="AR" term="%22Nasser+M%2E+Al-Daghri%22">Nasser M. Al-Daghri</searchLink><br /><searchLink fieldCode="AR" term="%22Shaun+Sabico%22">Shaun Sabico</searchLink><br /><searchLink fieldCode="AR" term="%22Cyrus+Cooper%22">Cyrus Cooper</searchLink><br /><searchLink fieldCode="AR" term="%22Renè+Rizzoli%22">Renè Rizzoli</searchLink><br /><searchLink fieldCode="AR" term="%22Jean-Yves+Reginster%22">Jean-Yves Reginster</searchLink><br /><searchLink fieldCode="AR" term="%22Mario+Barbagallo%22">Mario Barbagallo</searchLink><br /><searchLink fieldCode="AR" term="%22Ligia+J%2E+Dominguez%22">Ligia J. Dominguez</searchLink><br /><searchLink fieldCode="AR" term="%22Lee+Smith%22">Lee Smith</searchLink><br /><searchLink fieldCode="AR" term="%22Stefania+Maggi%22">Stefania Maggi</searchLink>
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  Data: Frontiers in Endocrinology, Vol 12 (2021)
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  Data: <searchLink fieldCode="DE" term="%22sarcopenia%22">sarcopenia</searchLink><br /><searchLink fieldCode="DE" term="%22osteoarthritis+of+the+knee%22">osteoarthritis of the knee</searchLink><br /><searchLink fieldCode="DE" term="%22older+people%22">older people</searchLink><br /><searchLink fieldCode="DE" term="%22epidemiology%22">epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22muscle+mass+and+function%22">muscle mass and function</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+endocrine+glands%2E+Clinical+endocrinology%22">Diseases of the endocrine glands. Clinical endocrinology</searchLink><br /><searchLink fieldCode="DE" term="%22RC648-665%22">RC648-665</searchLink>
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  Data: Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p
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    Subjects:
      – SubjectFull: sarcopenia
        Type: general
      – SubjectFull: osteoarthritis of the knee
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      – SubjectFull: muscle mass and function
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      – TitleFull: Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study
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