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Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis

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Title: Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Authors: Yan Sun, Shujun Sun, Pu Chen, Yan Dai, Dong Yang, Yun Lin, Lisha Yi
Source: Pharmacological Research, Vol 202, Iss , Pp 107113- (2024)
Publisher Information: Elsevier, 2024.
Publication Year: 2024
Collection: LCC:Therapeutics. Pharmacology
Subject Terms: Inflammation, Maresins, Organ dysfunction, Resolution, Sepsis, Therapeutics. Pharmacology, RM1-950
More Details: Sepsis, a complex clinical syndrome characterized by an exaggerated host response to infection, often necessitates hospitalization and intensive care unit admission. Delayed or inaccurate diagnosis of sepsis, coupled with suboptimal treatment strategies, can result in unfavorable outcomes, including mortality. Maresins, a newly discovered family of lipid mediators synthesized from docosahexaenoic acid by macrophages, have emerged as key players in promoting inflammation resolution and the termination of inflammatory processes. Extensive evidence has unequivocally demonstrated the beneficial effects of maresins in modulating the inflammatory response associated with sepsis; however, their bioactivity and functions exhibit remarkable diversity and complexity. This article presents a comprehensive review of recent research on the role of maresins in sepsis, aiming to enhance our understanding of their effectiveness and elucidate the specific mechanisms underlying their actions in sepsis treatment. Furthermore, emerging insights into the management of patients with sepsis are also highlighted.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1096-1186
Relation: http://www.sciencedirect.com/science/article/pii/S1043661824000574; https://doaj.org/toc/1096-1186
DOI: 10.1016/j.phrs.2024.107113
Access URL: https://doaj.org/article/23fa2a1dbe1e4abba43f196eb77a3a40
Accession Number: edsdoj.23fa2a1dbe1e4abba43f196eb77a3a40
Database: Directory of Open Access Journals
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  Data: Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
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  Data: <searchLink fieldCode="AR" term="%22Yan+Sun%22">Yan Sun</searchLink><br /><searchLink fieldCode="AR" term="%22Shujun+Sun%22">Shujun Sun</searchLink><br /><searchLink fieldCode="AR" term="%22Pu+Chen%22">Pu Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Yan+Dai%22">Yan Dai</searchLink><br /><searchLink fieldCode="AR" term="%22Dong+Yang%22">Dong Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Yun+Lin%22">Yun Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Lisha+Yi%22">Lisha Yi</searchLink>
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  Data: Pharmacological Research, Vol 202, Iss , Pp 107113- (2024)
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  Data: Sepsis, a complex clinical syndrome characterized by an exaggerated host response to infection, often necessitates hospitalization and intensive care unit admission. Delayed or inaccurate diagnosis of sepsis, coupled with suboptimal treatment strategies, can result in unfavorable outcomes, including mortality. Maresins, a newly discovered family of lipid mediators synthesized from docosahexaenoic acid by macrophages, have emerged as key players in promoting inflammation resolution and the termination of inflammatory processes. Extensive evidence has unequivocally demonstrated the beneficial effects of maresins in modulating the inflammatory response associated with sepsis; however, their bioactivity and functions exhibit remarkable diversity and complexity. This article presents a comprehensive review of recent research on the role of maresins in sepsis, aiming to enhance our understanding of their effectiveness and elucidate the specific mechanisms underlying their actions in sepsis treatment. Furthermore, emerging insights into the management of patients with sepsis are also highlighted.
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