Academic Journal
View in EDS

Organ-based characterization of B cells in patients with systemic lupus erythematosus

Bibliographic Details
Title: Organ-based characterization of B cells in patients with systemic lupus erythematosus
Authors: Yunan Wang, Rui Zhao, Qian Liang, Shiwen Ni, Mei Yang, Liwei Qiu, Juan Ji, Zhifeng Gu, Chen Dong
Source: Frontiers in Immunology, Vol 16 (2025)
Publisher Information: Frontiers Media S.A., 2025.
Publication Year: 2025
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: systemic lupus erythematosus, B cell, organ damage, organ specific features, therapy strategies, Immunologic diseases. Allergy, RC581-607
More Details: Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-3224
Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509033/full; https://doaj.org/toc/1664-3224
DOI: 10.3389/fimmu.2025.1509033
Access URL: https://doaj.org/article/20639f831bb1420abd357983e3e22eb0
Accession Number: edsdoj.20639f831bb1420abd357983e3e22eb0
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=16643224&ISBN=&volume=16&issue=&date=20250101&spage=&pages=&title=Frontiers in Immunology&atitle=Organ-based%20characterization%20of%20B%20cells%20in%20patients%20with%20systemic%20lupus%20erythematosus&aulast=Yunan%20Wang&id=DOI:10.3389/fimmu.2025.1509033
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/20639f831bb1420abd357983e3e22eb0
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.20639f831bb1420abd357983e3e22eb0
RelevancyScore: 1039
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1039.22692871094
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Organ-based characterization of B cells in patients with systemic lupus erythematosus
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yunan+Wang%22">Yunan Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Rui+Zhao%22">Rui Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Qian+Liang%22">Qian Liang</searchLink><br /><searchLink fieldCode="AR" term="%22Shiwen+Ni%22">Shiwen Ni</searchLink><br /><searchLink fieldCode="AR" term="%22Mei+Yang%22">Mei Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Liwei+Qiu%22">Liwei Qiu</searchLink><br /><searchLink fieldCode="AR" term="%22Juan+Ji%22">Juan Ji</searchLink><br /><searchLink fieldCode="AR" term="%22Zhifeng+Gu%22">Zhifeng Gu</searchLink><br /><searchLink fieldCode="AR" term="%22Chen+Dong%22">Chen Dong</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Immunology, Vol 16 (2025)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Frontiers Media S.A., 2025.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Immunologic diseases. Allergy
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22systemic+lupus+erythematosus%22">systemic lupus erythematosus</searchLink><br /><searchLink fieldCode="DE" term="%22B+cell%22">B cell</searchLink><br /><searchLink fieldCode="DE" term="%22organ+damage%22">organ damage</searchLink><br /><searchLink fieldCode="DE" term="%22organ+specific+features%22">organ specific features</searchLink><br /><searchLink fieldCode="DE" term="%22therapy+strategies%22">therapy strategies</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1664-3224
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509033/full; https://doaj.org/toc/1664-3224
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3389/fimmu.2025.1509033
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/20639f831bb1420abd357983e3e22eb0" linkWindow="_blank">https://doaj.org/article/20639f831bb1420abd357983e3e22eb0</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.20639f831bb1420abd357983e3e22eb0
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.20639f831bb1420abd357983e3e22eb0
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fimmu.2025.1509033
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: systemic lupus erythematosus
        Type: general
      – SubjectFull: B cell
        Type: general
      – SubjectFull: organ damage
        Type: general
      – SubjectFull: organ specific features
        Type: general
      – SubjectFull: therapy strategies
        Type: general
      – SubjectFull: Immunologic diseases. Allergy
        Type: general
      – SubjectFull: RC581-607
        Type: general
    Titles:
      – TitleFull: Organ-based characterization of B cells in patients with systemic lupus erythematosus
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yunan Wang
      – PersonEntity:
          Name:
            NameFull: Rui Zhao
      – PersonEntity:
          Name:
            NameFull: Qian Liang
      – PersonEntity:
          Name:
            NameFull: Shiwen Ni
      – PersonEntity:
          Name:
            NameFull: Mei Yang
      – PersonEntity:
          Name:
            NameFull: Liwei Qiu
      – PersonEntity:
          Name:
            NameFull: Juan Ji
      – PersonEntity:
          Name:
            NameFull: Zhifeng Gu
      – PersonEntity:
          Name:
            NameFull: Chen Dong
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 16643224
          Numbering:
            – Type: volume
              Value: 16
          Titles:
            – TitleFull: Frontiers in Immunology
              Type: main
ResultId 1