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Endoplasmic reticulum stress response pathway-mediated cell death in ovarian cancer

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Title: Endoplasmic reticulum stress response pathway-mediated cell death in ovarian cancer
Authors: Qiaochu Chen, Chan Li, Wei Wei, Jia Li, Fangyuan Liu, Yuqian Fu, Liping Tang, Fengjuan Han
Source: Frontiers in Oncology, Vol 14 (2024)
Publisher Information: Frontiers Media S.A., 2024.
Publication Year: 2024
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: ovarian cancer, endoplasmic reticulum stress response pathway, organelle, cell biology, cell death, potential therapeutic strategies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details: The endoplasmic reticulum (ER) is one of the largest organelles, and Endoplasmic Reticulum Stress Response Pathway is a series of responses triggered by the homeostatic imbalance of the ER and the state in which unfolded or misfolded proteins accumulate in the ER, which can trigger cell death. Cell death plays a crucial role in the development of diseases such as gynecological oncology. Herein, we review the current research on the response and ovarian cancer, discussing the key sensors (IRE1, PERK, ATF6), and the conditions under which it occurs (Ca2+ homeostasis disruption, hypoxia, others). Using the response as a starting point, provide a comprehensive overview of the relationship with the four types of cell death (apoptosis, autophagy, immunogenic cell death, paraptosis) in an attempt to provide new targeted therapeutic strategies for the organelle-Endoplasmic Reticulum Stress Response Pathway-cell death in ovarian cancer therapy.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2234-943X
Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1446552/full; https://doaj.org/toc/2234-943X
DOI: 10.3389/fonc.2024.1446552
Access URL: https://doaj.org/article/dccce1ff33c245a9989d58fed0a40dd0
Accession Number: edsdoj.1ff33c245a9989d58fed0a40dd0
Database: Directory of Open Access Journals
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  Data: Endoplasmic reticulum stress response pathway-mediated cell death in ovarian cancer
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  Data: <searchLink fieldCode="AR" term="%22Qiaochu+Chen%22">Qiaochu Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Chan+Li%22">Chan Li</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+Wei%22">Wei Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Jia+Li%22">Jia Li</searchLink><br /><searchLink fieldCode="AR" term="%22Fangyuan+Liu%22">Fangyuan Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yuqian+Fu%22">Yuqian Fu</searchLink><br /><searchLink fieldCode="AR" term="%22Liping+Tang%22">Liping Tang</searchLink><br /><searchLink fieldCode="AR" term="%22Fengjuan+Han%22">Fengjuan Han</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22ovarian+cancer%22">ovarian cancer</searchLink><br /><searchLink fieldCode="DE" term="%22endoplasmic+reticulum+stress+response+pathway%22">endoplasmic reticulum stress response pathway</searchLink><br /><searchLink fieldCode="DE" term="%22organelle%22">organelle</searchLink><br /><searchLink fieldCode="DE" term="%22cell+biology%22">cell biology</searchLink><br /><searchLink fieldCode="DE" term="%22cell+death%22">cell death</searchLink><br /><searchLink fieldCode="DE" term="%22potential+therapeutic+strategies%22">potential therapeutic strategies</searchLink><br /><searchLink fieldCode="DE" term="%22Neoplasms%2E+Tumors%2E+Oncology%2E+Including+cancer+and+carcinogens%22">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</searchLink><br /><searchLink fieldCode="DE" term="%22RC254-282%22">RC254-282</searchLink>
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  Data: The endoplasmic reticulum (ER) is one of the largest organelles, and Endoplasmic Reticulum Stress Response Pathway is a series of responses triggered by the homeostatic imbalance of the ER and the state in which unfolded or misfolded proteins accumulate in the ER, which can trigger cell death. Cell death plays a crucial role in the development of diseases such as gynecological oncology. Herein, we review the current research on the response and ovarian cancer, discussing the key sensors (IRE1, PERK, ATF6), and the conditions under which it occurs (Ca2+ homeostasis disruption, hypoxia, others). Using the response as a starting point, provide a comprehensive overview of the relationship with the four types of cell death (apoptosis, autophagy, immunogenic cell death, paraptosis) in an attempt to provide new targeted therapeutic strategies for the organelle-Endoplasmic Reticulum Stress Response Pathway-cell death in ovarian cancer therapy.
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        Value: 10.3389/fonc.2024.1446552
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: ovarian cancer
        Type: general
      – SubjectFull: endoplasmic reticulum stress response pathway
        Type: general
      – SubjectFull: organelle
        Type: general
      – SubjectFull: cell biology
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      – SubjectFull: cell death
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      – SubjectFull: potential therapeutic strategies
        Type: general
      – SubjectFull: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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      – SubjectFull: RC254-282
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